ID Q5YR07_NOCFA Unreviewed; 716 AA.
AC Q5YR07;
DT 23-NOV-2004, integrated into UniProtKB/TrEMBL.
DT 23-NOV-2004, sequence version 1.
DT 27-MAR-2024, entry version 120.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN OrderedLocusNames=NFA_45330 {ECO:0000313|EMBL:BAD59384.1};
OS Nocardia farcinica (strain IFM 10152).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Nocardia.
OX NCBI_TaxID=247156 {ECO:0000313|EMBL:BAD59384.1, ECO:0000313|Proteomes:UP000006820};
RN [1] {ECO:0000313|EMBL:BAD59384.1, ECO:0000313|Proteomes:UP000006820}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IFM 10152 {ECO:0000313|EMBL:BAD59384.1,
RC ECO:0000313|Proteomes:UP000006820};
RX PubMed=15466710; DOI=10.1073/pnas.0406410101;
RA Ishikawa J., Yamashita A., Mikami Y., Hoshino Y., Kurita H., Hotta K.,
RA Shiba T., Hattori M.;
RT "The complete genomic sequence of Nocardia farcinica IFM 10152.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:14925-14930(2004).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; AP006618; BAD59384.1; -; Genomic_DNA.
DR RefSeq; WP_011211068.1; NC_006361.1.
DR AlphaFoldDB; Q5YR07; -.
DR STRING; 247156.NFA_45330; -.
DR GeneID; 61135140; -.
DR KEGG; nfa:NFA_45330; -.
DR eggNOG; COG0210; Bacteria.
DR HOGENOM; CLU_004585_5_6_11; -.
DR OrthoDB; 9806690at2; -.
DR Proteomes; UP000006820; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF45; ATP-DEPENDENT DNA HELICASE UVRD2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00570; HRDC; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 2.
DR SMART; SM00341; HRDC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50967; HRDC; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000006820}.
FT DOMAIN 11..297
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 298..559
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT DOMAIN 634..714
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
FT BINDING 32..39
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 716 AA; 77227 MW; 43417F1381FACC79 CRC64;
MMVTVPALDL AALDPEQAAA VRAPRGPVCV LAGAGTGKTR TITYRIAHLV EAGHVKADQV
LAVTFTARAA GELRGRLRAL GLGGAANQVQ ARTFHAAALR QLKYFWPQVV GEVPWRLLEA
KFPVVAQAAH RVGLSTATES VRDLLTEIEW AKSSLVAPED YPAAAAAHHR DIPYDAGRIA
AVYTAYESLK TTPEGLLLDF DDLLLHTAAA LEDFPAVADE FRGRYRSFVV DEYQDVTPLQ
QRVLDAWLGE RDDLTVVGDA NQTIYSFTGA TPSYLLDFSR RFPDATVVRL ERDYRSTPQV
VSLANRVIGA ARGRIAGTRL QLVGQRPDGP EPEFAEYDDA PAEAAAVAAK IERLVAAGTP
PAEIAVLYRI NAQSEAYEQA LAERGIPFQV RGGEGFYQRA EVRQALGALR QAASRDDLPA
EARTGAALVR LVRAALAPVG LTATEPAGAQ ARERWASLTA LVTLTEELVA HDAALDLTGL
LRELAARAEA RHPPTVQGVT LASLHAAKGL EWDAVFLVGL TDGTLPIAHV LADDGSVADV
AALEEERRLL YVGVTRAREY LRLSWSLSRT EGGRRSRRRS RFLNGLVPDD SPASRVAAPA
MRPSEVNRPR CRVCAKPLIG TYATMLGRCR RCPAEVDADL LAALREWRAE KAGELGVREF
VVFTDTTLTA IAEQLPADDR ALAGIAGIGA KKIVDYGAEV LAIVASRVRS GSQNRR
//
