ID Q5YR35_NOCFA Unreviewed; 402 AA.
AC Q5YR35;
DT 23-NOV-2004, integrated into UniProtKB/TrEMBL.
DT 23-NOV-2004, sequence version 1.
DT 27-MAR-2024, entry version 122.
DE RecName: Full=galactokinase {ECO:0000256|ARBA:ARBA00012315};
DE EC=2.7.1.6 {ECO:0000256|ARBA:ARBA00012315};
DE AltName: Full=Galactose kinase {ECO:0000256|ARBA:ARBA00029590};
GN Name=galK {ECO:0000313|EMBL:BAD59356.1};
GN OrderedLocusNames=NFA_45050 {ECO:0000313|EMBL:BAD59356.1};
OS Nocardia farcinica (strain IFM 10152).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Nocardia.
OX NCBI_TaxID=247156 {ECO:0000313|EMBL:BAD59356.1, ECO:0000313|Proteomes:UP000006820};
RN [1] {ECO:0000313|EMBL:BAD59356.1, ECO:0000313|Proteomes:UP000006820}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IFM 10152 {ECO:0000313|EMBL:BAD59356.1,
RC ECO:0000313|Proteomes:UP000006820};
RX PubMed=15466710; DOI=10.1073/pnas.0406410101;
RA Ishikawa J., Yamashita A., Mikami Y., Hoshino Y., Kurita H., Hotta K.,
RA Shiba T., Hattori M.;
RT "The complete genomic sequence of Nocardia farcinica IFM 10152.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:14925-14930(2004).
CC -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC {ECO:0000256|ARBA:ARBA00004947}.
CC -!- SIMILARITY: Belongs to the GHMP kinase family. GalK subfamily.
CC {ECO:0000256|ARBA:ARBA00006566}.
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DR EMBL; AP006618; BAD59356.1; -; Genomic_DNA.
DR AlphaFoldDB; Q5YR35; -.
DR STRING; 247156.NFA_45050; -.
DR KEGG; nfa:NFA_45050; -.
DR eggNOG; COG0153; Bacteria.
DR HOGENOM; CLU_017814_2_1_11; -.
DR Proteomes; UP000006820; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004335; F:galactokinase activity; IEA:InterPro.
DR GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.70.890; GHMP kinase, C-terminal domain; 1.
DR InterPro; IPR000705; Galactokinase.
DR InterPro; IPR019741; Galactokinase_CS.
DR InterPro; IPR019539; GalKase_N.
DR InterPro; IPR013750; GHMP_kinase_C_dom.
DR InterPro; IPR036554; GHMP_kinase_C_sf.
DR InterPro; IPR006204; GHMP_kinase_N_dom.
DR InterPro; IPR006203; GHMP_knse_ATP-bd_CS.
DR InterPro; IPR006206; Mevalonate/galactokinase.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00131; gal_kin; 1.
DR PANTHER; PTHR10457:SF35; GALACTOKINASE; 1.
DR PANTHER; PTHR10457; MEVALONATE KINASE/GALACTOKINASE; 1.
DR Pfam; PF10509; GalKase_gal_bdg; 1.
DR Pfam; PF08544; GHMP_kinases_C; 1.
DR Pfam; PF00288; GHMP_kinases_N; 1.
DR PIRSF; PIRSF000530; Galactokinase; 1.
DR PRINTS; PR00473; GALCTOKINASE.
DR PRINTS; PR00959; MEVGALKINASE.
DR SUPFAM; SSF55060; GHMP Kinase, C-terminal domain; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00106; GALACTOKINASE; 1.
DR PROSITE; PS00627; GHMP_KINASES_ATP; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277};
KW Galactose metabolism {ECO:0000256|ARBA:ARBA00023144};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:BAD59356.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000006820};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 31..66
FT /note="Galactokinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF10509"
FT DOMAIN 124..190
FT /note="GHMP kinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00288"
FT DOMAIN 306..377
FT /note="GHMP kinase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08544"
SQ SEQUENCE 402 AA; 41689 MW; FB0FFC01DCC34AF3 CRC64;
MPGFVSSACR PARVGAGRAR AAAHNGPVVD TWVAPGRVNI IGEHTDYNDG YVLPIALPLV
TRCAARVTAQ PVVRVRSRQR PDEPVRAELD AIDAVRTQVP GWARYVLGVV GEFVRRGHPV
GGLDLEVDGA VPIGAGLSSS AALSCSVALA LRDLFAPQLS ERELIDVARA AENDYAGAPT
GVLDQSAAVL CTAGHALFLD VRRFTGAAPG TDPGYRQIPF DLARSGLTLL VIDTREAHEH
AGGGYAERRA QCEAAAAALG VAALRDVVVP GELGRIEDPV VRRRARHVVT ENARVLAVAE
TLRSGADPRE IGPILTAGHA SLRDDFEVST PALDLVVDAA LAAGAHGARM VGGGFGGSAI
ALVESGQADA VAAAVERRLG SAGHRAPRTF TVVPAAGAHR EN
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