ID Q5Z1I2_NOCFA Unreviewed; 859 AA.
AC Q5Z1I2;
DT 23-NOV-2004, integrated into UniProtKB/TrEMBL.
DT 23-NOV-2004, sequence version 1.
DT 27-MAR-2024, entry version 123.
DE SubName: Full=Putative ABC transporter ATP-binding protein {ECO:0000313|EMBL:BAD55709.1};
GN OrderedLocusNames=NFA_8640 {ECO:0000313|EMBL:BAD55709.1};
OS Nocardia farcinica (strain IFM 10152).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Nocardia.
OX NCBI_TaxID=247156 {ECO:0000313|EMBL:BAD55709.1, ECO:0000313|Proteomes:UP000006820};
RN [1] {ECO:0000313|EMBL:BAD55709.1, ECO:0000313|Proteomes:UP000006820}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IFM 10152 {ECO:0000313|EMBL:BAD55709.1,
RC ECO:0000313|Proteomes:UP000006820};
RX PubMed=15466710; DOI=10.1073/pnas.0406410101;
RA Ishikawa J., Yamashita A., Mikami Y., Hoshino Y., Kurita H., Hotta K.,
RA Shiba T., Hattori M.;
RT "The complete genomic sequence of Nocardia farcinica IFM 10152.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:14925-14930(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AP006618; BAD55709.1; -; Genomic_DNA.
DR RefSeq; WP_011207394.1; NC_006361.1.
DR AlphaFoldDB; Q5Z1I2; -.
DR STRING; 247156.NFA_8640; -.
DR GeneID; 61131692; -.
DR KEGG; nfa:NFA_8640; -.
DR eggNOG; COG0842; Bacteria.
DR eggNOG; COG1131; Bacteria.
DR eggNOG; COG1716; Bacteria.
DR HOGENOM; CLU_012042_1_0_11; -.
DR OrthoDB; 9804819at2; -.
DR Proteomes; UP000006820; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd00060; FHA; 1.
DR Gene3D; 2.60.200.20; -; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR48041:SF91; ABC TRANSPORTER EXPRESSED IN TRACHEA, ISOFORM A; 1.
DR PANTHER; PTHR48041; ABC TRANSPORTER G FAMILY MEMBER 28; 1.
DR Pfam; PF01061; ABC2_membrane; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR Pfam; PF00498; FHA; 2.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00240; FHA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000313|EMBL:BAD55709.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000006820};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 650..671
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 691..713
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 733..755
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 762..782
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 827..847
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 26..75
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT DOMAIN 221..270
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT DOMAIN 307..540
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 102..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 559..582
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 132..149
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 560..575
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 859 AA; 90808 MW; 3488407256419C92 CRC64;
MSSPGAQTIT VRHDGTERVF DSSQLVTLGR APEVTLFVDS PLVSRVHATL TWQGSGWVLT
DNGSTNGVFV DARRLTQPVS IDRPTQVRLG DAINGPLLHL LPAAPAQRPH PPQGAPSQGS
PQQGAPQHRP PQRPSYQRPP TPPYQPPHAA ARPGAAASGP QQAAPPSTGA APARPTPPPA
SQQQPNVNMT TKADTSALPP LRARASTAAI ARADRLPPGG LAIGRTTDNQ IVVNDPLASR
KHARLVAGRE GLTIEDLGSA NGTFVNGTRQ QRAVLREGDV ITIGNIDFVV QHGTLVLRQK
PVAEQGLHVH GVGFTVEGNK QLLVDVNMQA GRGTLTALIG PSGAGKSTLS KLIAGSTQPS
GGVVTFEGRN LHAEYEALRS RIGMVPQDDV LHRQLTVRQA LGYAAELRLP PDTTKADRQQ
VIDGVLQELS LTEHADTRVD RLSGGQRKRA SVALELLTGP SLLILDEPTS GLDPALDRQV
MVMLRELADA GRVVIVVTHS VACLDMCDQV LLLAPGGKTA FCGHPAGVGA ALGTSDWAEI
FANVAANPDQ AFAAYRSRQA VAPPPPPPPR YGPAGSPPQT SSIKQFSTLA RRQLRLIVSD
RVYSLSLLLM PIIVGAVTLA TPGKNGFQPP PLVQTPEGIG PAVSGEAQTL LSFLVIGACF
MGISLSVRDL VGERTIFLRE RAVGLSSTAY LLAKILVFSL AAVYQVAVML AIVLVGKNGP
RAGVVIPPGA VELFVDITLL AVCSVVLGLL ISSLVKSNEQ VMVVLVIAII VQLVMMGSFI
PVTGRPGLEQ VSWLFPSRWG FAASASTVDL TTLFVKAEQD TLWQHTAQWW VIDVSVLAAI
ALVLALFTRR NLRLKKSAT
//
