ID Q5ZI32_CHICK Unreviewed; 319 AA.
AC Q5ZI32;
DT 23-NOV-2004, integrated into UniProtKB/TrEMBL.
DT 23-NOV-2004, sequence version 1.
DT 27-MAR-2024, entry version 133.
DE SubName: Full=F-box protein 8 {ECO:0000313|Ensembl:ENSGALP00010003976.1};
GN Name=FBXO8 {ECO:0000313|Ensembl:ENSGALP00010003976.1};
GN ORFNames=RCJMB04_30p13 {ECO:0000313|EMBL:CAG32611.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|EMBL:CAG32611.1};
RN [1] {ECO:0000313|EMBL:CAG32611.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CB {ECO:0000313|EMBL:CAG32611.1};
RC TISSUE=Bursa {ECO:0000313|EMBL:CAG32611.1};
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
RN [2] {ECO:0000313|Ensembl:ENSGALP00010003976.1}
RP IDENTIFICATION.
RC STRAIN=broiler {ECO:0000313|Ensembl:ENSGALP00010003976.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJ720952; CAG32611.1; -; mRNA.
DR RefSeq; NP_001006446.1; NM_001006446.1.
DR RefSeq; XP_015131724.1; XM_015276238.1.
DR STRING; 9031.ENSGALP00000017484; -.
DR PaxDb; 9031-ENSGALP00000017484; -.
DR Ensembl; ENSGALT00010006444.1; ENSGALP00010003976.1; ENSGALG00010002779.1.
DR GeneID; 422565; -.
DR KEGG; gga:422565; -.
DR CTD; 26269; -.
DR VEuPathDB; HostDB:geneid_422565; -.
DR eggNOG; KOG0929; Eukaryota.
DR GeneTree; ENSGT00940000158356; -.
DR HOGENOM; CLU_057531_0_0_1; -.
DR OMA; NANPHEG; -.
DR OrthoDB; 204547at2759; -.
DR Proteomes; UP000000539; Chromosome 4.
DR Bgee; ENSGALG00000010764; Expressed in liver and 12 other cell types or tissues.
DR GO; GO:0000151; C:ubiquitin ligase complex; IEA:Ensembl.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR CDD; cd22088; F-box_FBXO8; 1.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.20.1280.50; -; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR048003; FBXO8_F-box.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF12937; F-box-like; 1.
DR Pfam; PF01369; Sec7; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF81383; F-box domain; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50181; FBOX; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP000000539}.
FT DOMAIN 68..111
FT /note="F-box"
FT /evidence="ECO:0000259|PROSITE:PS50181"
FT DOMAIN 133..314
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
SQ SEQUENCE 319 AA; 36909 MW; C802552C40F334B9 CRC64;
MGQGLWRVAR NQQLQHQGFS GQGYLTREHG RRIAANNVSN TSHRKQAQGG IDIYHLLKTR
KSKEQEGFIN LEMLPPELSF TILSYLNATD LCLASCVWQD LANDELLWQG LCKSTWGHCS
IYNKNPPLGF SFRKLYMQLD EGSLTFNANP DEGVNYFMSK GILDDSPKEI AKFIFCTRTL
NWKKLRIYLD ERRDVLDDLV TLHNFRNQFL PNALREFFRH IHAPEERGEY LETLITKFSH
RFCACNPDLM RELGLSPDAV YVLCYSLILL SIDLTSPHVK NKMSKREFIR NTRRAAQNIS
EDFVGHLYDN IYLIGHVAA
//
