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Database: UniProt
Entry: Q5ZK17
LinkDB: Q5ZK17
Original site: Q5ZK17 
ID   SETD6_CHICK             Reviewed;         447 AA.
AC   Q5ZK17;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 2.
DT   16-JAN-2019, entry version 73.
DE   RecName: Full=N-lysine methyltransferase SETD6;
DE            EC=2.1.1.-;
DE   AltName: Full=SET domain-containing protein 6;
GN   Name=SETD6; ORFNames=RCJMB04_13m6;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
OC   Phasianidae; Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J.,
RA   Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M.,
RA   Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Protein-lysine N-methyltransferase.
CC       {ECO:0000250|UniProtKB:Q8TBK2}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8TBK2}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding
CC       methyltransferase superfamily. Histone-lysine methyltransferase
CC       family. SETD6 subfamily. {ECO:0000255|PROSITE-ProRule:PRU00190}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAG31926.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
DR   EMBL; AJ720267; CAG31926.1; ALT_SEQ; mRNA.
DR   UniGene; Gga.4335; -.
DR   ProteinModelPortal; Q5ZK17; -.
DR   SMR; Q5ZK17; -.
DR   STRING; 9031.ENSGALP00000003512; -.
DR   PaxDb; Q5ZK17; -.
DR   eggNOG; KOG1338; Eukaryota.
DR   eggNOG; ENOG410ZN0H; LUCA.
DR   HOGENOM; HOG000203108; -.
DR   HOVERGEN; HBG108475; -.
DR   InParanoid; Q5ZK17; -.
DR   OrthoDB; 490654at2759; -.
DR   PhylomeDB; Q5ZK17; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0051059; F:NF-kappaB binding; IBA:GO_Central.
DR   GO; GO:0016279; F:protein-lysine N-methyltransferase activity; ISS:UniProtKB.
DR   GO; GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.
DR   GO; GO:0018026; P:peptidyl-lysine monomethylation; ISS:UniProtKB.
DR   GO; GO:0050727; P:regulation of inflammatory response; ISS:UniProtKB.
DR   Gene3D; 3.90.1420.10; -; 1.
DR   InterPro; IPR011383; N-lys_methylase_SETD6.
DR   InterPro; IPR015353; Rubisco_LSMT_subst-bd.
DR   InterPro; IPR036464; Rubisco_LSMT_subst-bd_sf.
DR   InterPro; IPR001214; SET_dom.
DR   Pfam; PF09273; Rubis-subs-bind; 1.
DR   Pfam; PF00856; SET; 1.
DR   PIRSF; PIRSF011771; RMS1_SET; 1.
DR   SUPFAM; SSF81822; SSF81822; 1.
DR   PROSITE; PS50280; SET; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Methyltransferase; Nucleus; Reference proteome;
KW   S-adenosyl-L-methionine; Transferase.
FT   CHAIN         1    447       N-lysine methyltransferase SETD6.
FT                                /FTId=PRO_0000281891.
FT   DOMAIN       34    259       SET. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00190}.
SQ   SEQUENCE   447 AA;  50649 MW;  86F7CF49BAFAA4FA CRC64;
     MAAPAKRRRA AGPDPDPTAG FVAWCEAAGV ELSPKVSISR RGTVSGYGLL AAADLEPGEL
     LFSVPRSALL SQHTCAIRAL LHDAQESLQS QSVWVPLLLA LLHEYTTGTS RWRPYFSLWQ
     DFSSLDHPMF WPEEERVRLL QGTGIPEAVD KDLANIQLEY SSIILPFMKS HPDIFDPELH
     TLELYKQLVA FVMAYSFQEP LEEEDEDEKG PNPPMMVPVA DILNHVANHN ASLEYAPTCL
     RMVTTQPISK GQEIFNTYGQ MANWQLLHMY GFAEPYPGNT NDTADIQMVT VRKAALQRAK
     NEAQQQLVAE QWDFLCQLEM VGEEGAFVLG WDEVLTEEEL SVTLKVLCMS EEEFKEYKEQ
     DGWEDDSEEE ENSTLSNAAL SRLKAPCKAL LYDSVLLTLE SYRSDLRAEQ DLLSKQVYEK
     LSRREQQALH VRYGQKRILH QLLELVQ
//
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