ID SETD6_CHICK Reviewed; 447 AA.
AC Q5ZK17;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2007, sequence version 2.
DT 27-MAR-2024, entry version 86.
DE RecName: Full=N-lysine methyltransferase SETD6;
DE EC=2.1.1.-;
DE AltName: Full=SET domain-containing protein 6;
GN Name=SETD6; ORFNames=RCJMB04_13m6;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Protein-lysine N-methyltransferase.
CC {ECO:0000250|UniProtKB:Q8TBK2}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8TBK2}.
CC -!- SIMILARITY: Belongs to the class V-like SAM-binding methyltransferase
CC superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.
CC {ECO:0000255|PROSITE-ProRule:PRU00190}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAG31926.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJ720267; CAG31926.1; ALT_SEQ; mRNA.
DR AlphaFoldDB; Q5ZK17; -.
DR SMR; Q5ZK17; -.
DR STRING; 9031.ENSGALP00000003512; -.
DR PaxDb; 9031-ENSGALP00000003512; -.
DR VEuPathDB; HostDB:geneid_101750922; -.
DR eggNOG; KOG1338; Eukaryota.
DR InParanoid; Q5ZK17; -.
DR PhylomeDB; Q5ZK17; -.
DR Proteomes; UP000000539; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0016279; F:protein-lysine N-methyltransferase activity; ISS:UniProtKB.
DR GO; GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.
DR GO; GO:0018026; P:peptidyl-lysine monomethylation; ISS:UniProtKB.
DR GO; GO:0050727; P:regulation of inflammatory response; ISS:UniProtKB.
DR CDD; cd19178; SET_SETD6; 1.
DR Gene3D; 3.90.1420.10; Rubisco LSMT, substrate-binding domain; 1.
DR Gene3D; 3.90.1410.10; set domain protein methyltransferase, domain 1; 1.
DR InterPro; IPR011383; N-lys_methylase_SETD6.
DR InterPro; IPR015353; Rubisco_LSMT_subst-bd.
DR InterPro; IPR036464; Rubisco_LSMT_subst-bd_sf.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR044430; SETD6_SET.
DR PANTHER; PTHR13271:SF34; N-LYSINE METHYLTRANSFERASE SETD6; 1.
DR PANTHER; PTHR13271; UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE; 1.
DR Pfam; PF09273; Rubis-subs-bind; 1.
DR Pfam; PF00856; SET; 1.
DR PIRSF; PIRSF011771; RMS1_SET; 1.
DR SUPFAM; SSF81822; RuBisCo LSMT C-terminal, substrate-binding domain; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50280; SET; 1.
PE 2: Evidence at transcript level;
KW Methyltransferase; Nucleus; Reference proteome; S-adenosyl-L-methionine;
KW Transferase.
FT CHAIN 1..447
FT /note="N-lysine methyltransferase SETD6"
FT /id="PRO_0000281891"
FT DOMAIN 34..259
FT /note="SET"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00190"
SQ SEQUENCE 447 AA; 50649 MW; 86F7CF49BAFAA4FA CRC64;
MAAPAKRRRA AGPDPDPTAG FVAWCEAAGV ELSPKVSISR RGTVSGYGLL AAADLEPGEL
LFSVPRSALL SQHTCAIRAL LHDAQESLQS QSVWVPLLLA LLHEYTTGTS RWRPYFSLWQ
DFSSLDHPMF WPEEERVRLL QGTGIPEAVD KDLANIQLEY SSIILPFMKS HPDIFDPELH
TLELYKQLVA FVMAYSFQEP LEEEDEDEKG PNPPMMVPVA DILNHVANHN ASLEYAPTCL
RMVTTQPISK GQEIFNTYGQ MANWQLLHMY GFAEPYPGNT NDTADIQMVT VRKAALQRAK
NEAQQQLVAE QWDFLCQLEM VGEEGAFVLG WDEVLTEEEL SVTLKVLCMS EEEFKEYKEQ
DGWEDDSEEE ENSTLSNAAL SRLKAPCKAL LYDSVLLTLE SYRSDLRAEQ DLLSKQVYEK
LSRREQQALH VRYGQKRILH QLLELVQ
//
