ID   INT14_CHICK             Reviewed;         518 AA.
AC   Q5ZK21;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   24-JAN-2024, entry version 96.
DE   RecName: Full=Integrator complex subunit 14 {ECO:0000250|UniProtKB:Q96SY0};
DE   AltName: Full=von Willebrand factor A domain-containing protein 9 {ECO:0000305};
GN   Name=INTS14 {ECO:0000250|UniProtKB:Q96SY0}; Synonyms=VWA9 {ECO:0000305};
GN   ORFNames=RCJMB04_13l3;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Probable component of the Integrator (INT) complex, a complex
CC       involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and
CC       in their 3'-box-dependent processing. {ECO:0000250|UniProtKB:Q9VPY0}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9VPY0}.
CC   -!- SIMILARITY: Belongs to the INTS14 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AJ720263; CAG31922.1; -; mRNA.
DR   RefSeq; NP_001005825.1; NM_001005825.1.
DR   RefSeq; XP_015147579.1; XM_015292093.1.
DR   RefSeq; XP_015147580.1; XM_015292094.1.
DR   AlphaFoldDB; Q5ZK21; -.
DR   SMR; Q5ZK21; -.
DR   STRING; 9031.ENSGALP00000070915; -.
DR   PaxDb; 9031-ENSGALP00000041054; -.
DR   Ensembl; ENSGALT00000094572; ENSGALP00000072710; ENSGALG00000007491.
DR   Ensembl; ENSGALT00010043060.1; ENSGALP00010025550.1; ENSGALG00010017815.1.
DR   Ensembl; ENSGALT00015057091; ENSGALP00015034709; ENSGALG00015023335.
DR   GeneID; 415540; -.
DR   KEGG; gga:415540; -.
DR   CTD; 415540; -.
DR   VEuPathDB; HostDB:geneid_415540; -.
DR   eggNOG; ENOG502QQ37; Eukaryota.
DR   GeneTree; ENSGT00390000009486; -.
DR   HOGENOM; CLU_041485_0_0_1; -.
DR   InParanoid; Q5ZK21; -.
DR   OMA; QSSVVWI; -.
DR   OrthoDB; 3673014at2759; -.
DR   PhylomeDB; Q5ZK21; -.
DR   TreeFam; TF323245; -.
DR   Reactome; R-GGA-6807505; RNA polymerase II transcribes snRNA genes.
DR   PRO; PR:Q5ZK21; -.
DR   Proteomes; UP000000539; Chromosome 10.
DR   Bgee; ENSGALG00000007491; Expressed in spermatocyte and 13 other cell types or tissues.
DR   GO; GO:0032039; C:integrator complex; IEA:InterPro.
DR   GO; GO:0034472; P:snRNA 3'-end processing; IBA:GO_Central.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR039841; INTS14.
DR   InterPro; IPR045814; IntS14_b-barrel.
DR   InterPro; IPR046471; IntS14_C.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR13532:SF3; INTEGRATOR COMPLEX SUBUNIT 14; 1.
DR   PANTHER; PTHR13532; UNCHARACTERIZED; 1.
DR   Pfam; PF19435; IntS14_b-barrel; 1.
DR   Pfam; PF20504; IntS14_C; 1.
DR   Pfam; PF13519; VWA_2; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..518
FT                   /note="Integrator complex subunit 14"
FT                   /id="PRO_0000296270"
FT   DOMAIN          2..204
FT                   /note="VWFA"
FT   REGION          373..394
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   518 AA;  57533 MW;  C662196CCADDC5D9 CRC64;
     MPTVVVMDVS LSMTRPVSVE GSEEYQRKHL AVHGLTMLFE HMATNYKLEF TALVVFSSLW
     ELMVPFTRDY NTLQEALSNM DDYDKTCLES ALLGVCNIVQ QEWGAAIPCQ VVLVTDGCLG
     IGRGSLRHSL ATHNQRSESN RFPLPFPFPS KLYVMCMANL EELQSTDSLD CLERLIDLNN
     GEGQIFTIDG PLCLKNVQSM FGKLIDLAYT PFHAVLKCGH LTSDVQVFPR PEPFIIDEEI
     DPIPKAINTD LEIVGFVDIA DISSPPVLSR HLVLPIALNR EGDEVGPGIT DDTEDENSAN
     QIAGKIPNFC VLLHGSLKVE GMVAVVQLGP EWYGMLYSQA DSKKKSNLMM SLFEPGPEPL
     PWLGKMAQLG PISDAKENPY GDDDNKSPFP LQPKNKRSYA QNVTVWIKPS GLQTDVQKIL
     RNARKLPEKT QTFYKELNRL RKAALAFGFL DLLKGVADML ERECTLLPDT AHPDAAFQLT
     HAAQQLKVAS TGASEYTAYD HNIAPLQTDF PTTSTERM
//