GenomeNet

Database: UniProt
Entry: Q5ZKB9
LinkDB: Q5ZKB9
Original site: Q5ZKB9 
ID   DDX6_CHICK              Reviewed;         483 AA.
AC   Q5ZKB9;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   16-OCT-2019, entry version 112.
DE   RecName: Full=Probable ATP-dependent RNA helicase DDX6;
DE            EC=3.6.4.13;
DE   AltName: Full=DEAD box protein 6;
GN   Name=DDX6; ORFNames=RCJMB04_11n24;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
OC   Phasianidae; Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J.,
RA   Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M.,
RA   Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: In the process of mRNA degradation, may play a role in
CC       mRNA decapping. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBUNIT: Forms a complex with DCP1A, DCP2, EDC3 and EDC4/HEDLS.
CC       Interacts with LIMD1, WTIP and AJUBA. Interacts with APOBEC3G in
CC       an RNA-dependent manner (By similarity). Interacts with RC3H1 (By
CC       similarity). Interacts with ATXN2L. Interacts with MCRIP1 (By
CC       similarity). Interacts with MCRIP2 (By similarity). Interacts with
CC       NUFIP2 (By similarity). {ECO:0000250|UniProtKB:P26196,
CC       ECO:0000250|UniProtKB:P54823}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, P-body
CC       {ECO:0000250|UniProtKB:P26196}. Cytoplasm
CC       {ECO:0000250|UniProtKB:P26196}. Nucleus
CC       {ECO:0000250|UniProtKB:P26196}. Note=Upon cellular stress,
CC       relocalizes to stress granules. {ECO:0000250|UniProtKB:P26196}.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX6/DHH1
CC       subfamily. {ECO:0000305}.
DR   EMBL; AJ720165; CAG31824.1; -; mRNA.
DR   RefSeq; NP_001268976.1; NM_001282047.3.
DR   RefSeq; XP_015153490.1; XM_015298004.1.
DR   SMR; Q5ZKB9; -.
DR   BioGrid; 680837; 1.
DR   STRING; 9031.ENSGALP00000039796; -.
DR   PaxDb; Q5ZKB9; -.
DR   PRIDE; Q5ZKB9; -.
DR   Ensembl; ENSGALT00000058124; ENSGALP00000046305; ENSGALG00000033064.
DR   Ensembl; ENSGALT00000107898; ENSGALP00000065105; ENSGALG00000033064.
DR   GeneID; 419783; -.
DR   KEGG; gga:419783; -.
DR   CTD; 1656; -.
DR   eggNOG; KOG0326; Eukaryota.
DR   eggNOG; ENOG410XRAZ; LUCA.
DR   GeneTree; ENSGT00900000141067; -.
DR   HOGENOM; HOG000268797; -.
DR   InParanoid; Q5ZKB9; -.
DR   KO; K12614; -.
DR   OrthoDB; 583315at2759; -.
DR   PhylomeDB; Q5ZKB9; -.
DR   TreeFam; TF300440; -.
DR   PRO; PR:Q5ZKB9; -.
DR   Proteomes; UP000000539; Chromosome 24.
DR   GO; GO:0010494; C:cytoplasmic stress granule; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000932; C:P-body; IBA:GO_Central.
DR   GO; GO:0016442; C:RISC complex; IEA:Ensembl.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR   GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0033962; P:cytoplasmic mRNA processing body assembly; IBA:GO_Central.
DR   GO; GO:0045665; P:negative regulation of neuron differentiation; IEA:Ensembl.
DR   GO; GO:0019827; P:stem cell population maintenance; IEA:Ensembl.
DR   GO; GO:0034063; P:stress granule assembly; IBA:GO_Central.
DR   GO; GO:0019074; P:viral RNA genome packaging; IEA:Ensembl.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Complete proteome; Cytoplasm; Helicase; Hydrolase;
KW   Nucleotide-binding; Nucleus; Reference proteome; RNA-binding.
FT   CHAIN         1    483       Probable ATP-dependent RNA helicase DDX6.
FT                                /FTId=PRO_0000274533.
FT   DOMAIN      127    298       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      308    468       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND     140    147       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   MOTIF        96    124       Q motif.
FT   MOTIF       246    249       DEAD box.
SQ   SEQUENCE   483 AA;  54418 MW;  3BDAD7762260AC94 CRC64;
     MSTARTENPV IMGLSSQNGQ LRGPVKPSGG PGGGGTQTQQ QMNQLKNANT INNGTQQQAQ
     SMTTTIKPGD DWKKTLKLPP KDLRIKTSDV TSTKGNEFED YCLKRELLMG IFEMGWEKPS
     PIQEESIPIA LSGRDILARA KNGTGKSGAY LIPLLERLDL KKDNIQAMVI VPTRELALQV
     SQICIQVSKH MGGAKVMATT GGTNLRDDIM RLDDTVHVVI ATPGRILDLI KKGVAKVEHV
     QMIVLDEADK LLSQDFVQIM EDIILTLPKN RQILLYSATF PLSVQKFMNS HLQKPYEINL
     MEELTLKGVT QYYAYVTERQ KVHCLNTLFS RLQINQSIIF CNSSQRVELL AKKISQLGYS
     CFYIHAKMRQ EHRNRVFHDF RNGLCRNLVC TDLFTRGIDI QAVNVVINFD FPKLAETYLH
     RIGRSGRFGH LGLAINLITY DDRFNLKSIE EQLGTEIKPI PSNIDKSLYV AEYHSEPVED
     EKQ
//
DBGET integrated database retrieval system