ID   EED_CHICK               Reviewed;         446 AA.
AC   Q5ZKH3;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   27-MAR-2024, entry version 123.
DE   RecName: Full=Polycomb protein EED;
GN   Name=EED; ORFNames=RCJMB04_10n8;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2
CC       complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading
CC       to transcriptional repression of the affected target gene (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the PRC2/EED-EZH2 complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat ESC family. {ECO:0000305}.
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DR   EMBL; AJ720111; CAG31770.1; -; mRNA.
DR   RefSeq; NP_001026547.1; NM_001031376.1.
DR   AlphaFoldDB; Q5ZKH3; -.
DR   SMR; Q5ZKH3; -.
DR   STRING; 9031.ENSGALP00000057840; -.
DR   PaxDb; 9031-ENSGALP00000022724; -.
DR   GeneID; 426381; -.
DR   KEGG; gga:426381; -.
DR   CTD; 8726; -.
DR   VEuPathDB; HostDB:geneid_426381; -.
DR   eggNOG; KOG1034; Eukaryota.
DR   HOGENOM; CLU_032683_1_0_1; -.
DR   InParanoid; Q5ZKH3; -.
DR   PhylomeDB; Q5ZKH3; -.
DR   Reactome; R-GGA-212300; PRC2 methylates histones and DNA.
DR   Reactome; R-GGA-2559580; Oxidative Stress Induced Senescence.
DR   Reactome; R-GGA-8943724; Regulation of PTEN gene transcription.
DR   Reactome; R-GGA-8953750; Transcriptional Regulation by E2F6.
DR   PRO; PR:Q5ZKH3; -.
DR   Proteomes; UP000000539; Chromosome 1.
DR   Bgee; ENSGALG00000014060; Expressed in spleen and 12 other cell types or tissues.
DR   GO; GO:0035098; C:ESC/E(Z) complex; ISS:UniProtKB.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR10253; POLYCOMB PROTEIN; 1.
DR   PANTHER; PTHR10253:SF5; POLYCOMB PROTEIN EED; 1.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Chromatin regulator; Nucleus; Reference proteome; Repeat; Repressor;
KW   Transcription; Transcription regulation; WD repeat.
FT   CHAIN           1..446
FT                   /note="Polycomb protein EED"
FT                   /id="PRO_0000343727"
FT   REPEAT          96..139
FT                   /note="WD 1"
FT   REPEAT          147..190
FT                   /note="WD 2"
FT   REPEAT          193..233
FT                   /note="WD 3"
FT   REPEAT          239..280
FT                   /note="WD 4"
FT   REPEAT          309..346
FT                   /note="WD 5"
FT   REPEAT          364..404
FT                   /note="WD 6"
FT   REPEAT          413..446
FT                   /note="WD 7"
FT   REGION          1..77
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        46..69
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   446 AA;  50378 MW;  7AB0D05AC900B8B6 CRC64;
     MSERGEAPAA AASAGAGGEM PAKKQKLSSD ENSNPGDLSG DENDDAVSIE SGTNTERPDT
     PTNTPNAPGR KSWGKGKWKS KKCKYSFKCV NSLKEDHGQP LFGVQFNWHS KEGDPLVFAT
     VGSNRVTLYE CHSQGEIRLL QSYVDADADE NFYTCAWTYD SNTSHPLLAV AGSRGIIRII
     NPITMQCIKH YVGHGNAINE LKFHPRDPNL LLSVSKDHAL RLWNIQTDTL VAIFGGVEGH
     RDEVLSADYD LLGEKIMSCG MDHSLKLWRI NSKRMINAIK ESYEYNPNKT NRPFISQKIH
     FPDFSTRDIH RNYVDCVRWL GDLILSKSCE NAIVCWKPGK MEDDIDKIKP SESNVTILGR
     FDYSQCDIWY MRFSMDFWQK MLALGNQVGK LYVWDLEIED PHKAKCTTLT HPKCVAAIRQ
     TSFSRDSSIL IAVCDDASIW RWDRLR
//