ID EDF1_CHICK Reviewed; 148 AA.
AC Q5ZMC0;
DT 12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 24-JAN-2024, entry version 111.
DE RecName: Full=Endothelial differentiation-related factor 1 homolog;
DE Short=EDF-1;
GN Name=EDF1; ORFNames=RCJMB04_2j2;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Probable transcriptional coactivator. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR EMBL; AJ719464; CAG31123.1; -; mRNA.
DR RefSeq; NP_001006203.1; NM_001006203.1.
DR AlphaFoldDB; Q5ZMC0; -.
DR SMR; Q5ZMC0; -.
DR STRING; 9031.ENSGALP00000058327; -.
DR PaxDb; 9031-ENSGALP00000014641; -.
DR Ensembl; ENSGALT00000069680; ENSGALP00000058327; ENSGALG00000038003.
DR Ensembl; ENSGALT00010068924.1; ENSGALP00010042366.1; ENSGALG00010028462.1.
DR Ensembl; ENSGALT00015068326; ENSGALP00015041966; ENSGALG00015028104.
DR GeneID; 417286; -.
DR KEGG; gga:417286; -.
DR CTD; 8721; -.
DR VEuPathDB; HostDB:geneid_417286; -.
DR eggNOG; KOG3398; Eukaryota.
DR GeneTree; ENSGT00390000008519; -.
DR HOGENOM; CLU_112609_0_1_1; -.
DR InParanoid; Q5ZMC0; -.
DR OMA; NKAHQGT; -.
DR OrthoDB; 120438at2759; -.
DR PhylomeDB; Q5ZMC0; -.
DR TreeFam; TF300064; -.
DR PRO; PR:Q5ZMC0; -.
DR Proteomes; UP000000539; Chromosome 17.
DR Bgee; ENSGALG00000038003; Expressed in lung and 14 other cell types or tissues.
DR ExpressionAtlas; Q5ZMC0; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR CDD; cd00093; HTH_XRE; 1.
DR Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1.
DR InterPro; IPR001387; Cro/C1-type_HTH.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR013729; MBF1_N.
DR PANTHER; PTHR10245:SF15; ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1; 1.
DR PANTHER; PTHR10245; ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1 MULTIPROTEIN BRIDGING FACTOR 1; 1.
DR Pfam; PF01381; HTH_3; 1.
DR Pfam; PF08523; MBF1; 1.
DR SMART; SM00530; HTH_XRE; 1.
DR SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1.
DR PROSITE; PS50943; HTH_CROC1; 1.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..148
FT /note="Endothelial differentiation-related factor 1
FT homolog"
FT /id="PRO_0000149798"
FT DOMAIN 81..135
FT /note="HTH cro/C1-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00257"
FT DNA_BIND 92..111
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00257"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 148 AA; 16364 MW; 8CE1DD092644B316 CRC64;
MAESDWDTVT VLRKKGPSAA QAKSKQAVLA AQRRGEDVET SKKWAAGQNK QHFITKNTAK
LDRETEELHH DRVPLEVGKV IQQGRQSKGM TQKDLATKIN EKPQVIADYE SGRAIPNNQV
MGKIERAIGL KLRGKDIGKP LETGPKGK
//
