ID WDR82_CHICK Reviewed; 313 AA.
AC Q5ZMV7;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 27-MAR-2024, entry version 109.
DE RecName: Full=WD repeat-containing protein 82 {ECO:0000305};
GN Name=WDR82; ORFNames=RCJMB04_1b3 {ECO:0000303|PubMed:15642098};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Regulatory component of the SET1 complex implicated in the
CC tethering of this complex to transcriptional start sites of active
CC genes. Facilitates histone H3 'Lys-4' methylation (H3K4me) via
CC recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-
CC terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Part
CC of a transcription termination checkpoint that promotes transcription
CC termination of long non-coding RNAs (lncRNAs).
CC {ECO:0000250|UniProtKB:Q6UXN9}.
CC -!- SUBUNIT: Component of the SET1 complex. {ECO:0000250|UniProtKB:Q6UXN9}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q6UXN9}.
CC Chromosome {ECO:0000250|UniProtKB:Q8BFQ4}. Note=Associates with
CC chromatin (By similarity). Recruited at sites of high RNA polymerase II
CC occupancy (By similarity). {ECO:0000250|UniProtKB:Q6UXN9,
CC ECO:0000250|UniProtKB:Q8BFQ4}.
CC -!- SIMILARITY: Belongs to the WD repeat SWD2 family. {ECO:0000305}.
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DR EMBL; AJ719277; CAG30936.1; -; mRNA.
DR RefSeq; NP_001006135.1; NM_001006135.1.
DR AlphaFoldDB; Q5ZMV7; -.
DR SMR; Q5ZMV7; -.
DR STRING; 9031.ENSGALP00000035502; -.
DR PaxDb; 9031-ENSGALP00000035502; -.
DR Ensembl; ENSGALT00000036280; ENSGALP00000035502; ENSGALG00000025904.
DR GeneID; 415942; -.
DR KEGG; gga:415942; -.
DR CTD; 80335; -.
DR VEuPathDB; HostDB:geneid_415942; -.
DR eggNOG; KOG1446; Eukaryota.
DR HOGENOM; CLU_044117_3_0_1; -.
DR InParanoid; Q5ZMV7; -.
DR OMA; HNEGYIR; -.
DR OrthoDB; 176818at2759; -.
DR PRO; PR:Q5ZMV7; -.
DR Proteomes; UP000000539; Chromosome 12.
DR Bgee; ENSGALG00000025904; Expressed in spermatid and 12 other cell types or tissues.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0048188; C:Set1C/COMPASS complex; IBA:GO_Central.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0006353; P:DNA-templated transcription termination; IEA:UniProtKB-KW.
DR GO; GO:0110064; P:lncRNA catabolic process; ISS:UniProtKB.
DR GO; GO:0032785; P:negative regulation of DNA-templated transcription, elongation; ISS:UniProtKB.
DR GO; GO:0140744; P:negative regulation of lncRNA transcription; ISS:UniProtKB.
DR GO; GO:0071027; P:nuclear RNA surveillance; ISS:UniProtKB.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR037867; Swd2/WDR82.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19861:SF0; WD REPEAT-CONTAINING PROTEIN 82; 1.
DR PANTHER; PTHR19861; WD40 REPEAT PROTEIN SWD2; 1.
DR Pfam; PF00400; WD40; 3.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Chromosome; Nucleus; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Transcription termination; WD repeat.
FT CHAIN 1..313
FT /note="WD repeat-containing protein 82"
FT /id="PRO_0000279687"
FT REPEAT 19..58
FT /note="WD 1"
FT REPEAT 105..144
FT /note="WD 2"
FT REPEAT 146..184
FT /note="WD 3"
FT REPEAT 192..231
FT /note="WD 4"
FT REPEAT 236..276
FT /note="WD 5"
FT REPEAT 280..313
FT /note="WD 6"
SQ SEQUENCE 313 AA; 35105 MW; E55B655C27F198D9 CRC64;
MKLTDNVLRS FRVAKVFREN SDKINCFDFS PNGETVISSS DDDSIVLYDC QEGKPKRTLY
SKKYGVDLIR YTHAANTVVY SSNKIDDTIR YLSLHDNKYI RYFPGHTKRV VALSMSPVDD
TFISGSLDKT IRLWDLRSPN CQGLMHLQGK PVCSFDPEGL IFAAGVNSEM VKLYDLRSFD
KGPFATFKMQ YDRTCEWTGL KFSNDGKLIL ISTNGGFIRL IDAFKGAVLH TFGGYNNSKA
VTLEASFTPD SQFIMIGSED GKIHVWNGES GMKVAVLDGK HTGPITCLQF NPKFMTFASA
CSNMAFWLPT IDD
//
