ID Q5ZR77_CAEEL Unreviewed; 489 AA.
AC Q5ZR77;
DT 23-NOV-2004, integrated into UniProtKB/TrEMBL.
DT 23-NOV-2004, sequence version 1.
DT 24-JAN-2024, entry version 127.
DE SubName: Full=Cation efflux protein cytoplasmic domain-containing protein {ECO:0000313|EMBL:CCD67012.1};
GN ORFNames=CELE_R02F11.3 {ECO:0000313|EMBL:CCD67012.1}, R02F11.3
GN {ECO:0000313|EMBL:CCD67012.1, ECO:0000313|WormBase:R02F11.3b};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD67012.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CCD67012.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD67012.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the cation diffusion facilitator (CDF)
CC transporter (TC 2.A.4) family. SLC30A subfamily.
CC {ECO:0000256|ARBA:ARBA00008873}.
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DR EMBL; BX284605; CCD67012.1; -; Genomic_DNA.
DR RefSeq; NP_001024066.1; NM_001028895.3.
DR AlphaFoldDB; Q5ZR77; -.
DR STRING; 6239.R02F11.3b.1; -.
DR EPD; Q5ZR77; -.
DR PaxDb; 6239-R02F11-3b; -.
DR PeptideAtlas; Q5ZR77; -.
DR EnsemblMetazoa; R02F11.3b.1; R02F11.3b.1; WBGene00019841.
DR GeneID; 178869; -.
DR UCSC; R02F11.3a; c. elegans.
DR AGR; WB:WBGene00019841; -.
DR WormBase; R02F11.3b; CE37658; WBGene00019841; -.
DR eggNOG; KOG1485; Eukaryota.
DR InParanoid; Q5ZR77; -.
DR OMA; RYKEPSV; -.
DR OrthoDB; 5479358at2759; -.
DR PhylomeDB; Q5ZR77; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00019841; Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues.
DR ExpressionAtlas; Q5ZR77; baseline and differential.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IBA:GO_Central.
DR Gene3D; 1.20.1510.10; Cation efflux protein transmembrane domain; 1.
DR Gene3D; 3.30.70.1350; Cation efflux protein, cytoplasmic domain; 1.
DR InterPro; IPR002524; Cation_efflux.
DR InterPro; IPR027470; Cation_efflux_CTD.
DR InterPro; IPR036837; Cation_efflux_CTD_sf.
DR InterPro; IPR027469; Cation_efflux_TMD_sf.
DR NCBIfam; TIGR01297; CDF; 1.
DR PANTHER; PTHR43840; MITOCHONDRIAL METAL TRANSPORTER 1-RELATED; 1.
DR PANTHER; PTHR43840:SF13; ZT_DIMER DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01545; Cation_efflux; 1.
DR Pfam; PF16916; ZT_dimer; 1.
DR SUPFAM; SSF160240; Cation efflux protein cytoplasmic domain-like; 1.
DR SUPFAM; SSF161111; Cation efflux protein transmembrane domain-like; 1.
PE 1: Evidence at protein level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|EPD:Q5ZR77,
KW ECO:0007829|PeptideAtlas:Q5ZR77};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 194..215
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 221..241
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 262..284
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 304..327
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 401..475
FT /note="Cation efflux protein cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF16916"
FT REGION 1..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 157..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..54
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..188
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 489 AA; 54869 MW; BC633AE54A468B4D CRC64;
MTKTEATFSL LDEEEERDEV GPSTVLVPGR PSLRSISLSQ APSAPRDLEN GNGQTSCAEL
HKLTAGSTTS LSSQSKNAKK VNKFYKKQNE LLENFKNDSE QIEQFNRTRR RTTSKEEDDD
ADVIAAIPPP IPEEKAVVAP LVKHIDGTDE PEVVIFDVPR SPRNPRKKPM ERTDTEEKSV
DEKKDDESNT AARMANITLA VNFLLMIAKV VASVLSGSMS IISSMVDSVV DITSGLVISL
SERMIKKRDP YLYPRGRTRL EPLSLILISV IMGMASIQLI IASVRGIHDG IQFHLYGIGE
EPKLNVTITS VVIMVSTVLV KLSLYLFCKR YKEPSVNVLA MDHRNDCISN TVALICAWLG
TKYSYYFDPA GAIVVSMYIL YTWVQTGREH LAKLSGKTAE PEFINRIIKV CLDHDARISH
IDTVYVYHFG SKFLVEVHIV LDENMILKES HDISETLQSN IESLPEVERA FVHTDYDYDH
HPHDEHKIV
//
