ID Q5ZT68_LEGPH Unreviewed; 667 AA.
AC Q5ZT68;
DT 23-NOV-2004, integrated into UniProtKB/TrEMBL.
DT 23-NOV-2004, sequence version 1.
DT 27-MAR-2024, entry version 93.
DE RecName: Full=Ribonuclease G {ECO:0000256|ARBA:ARBA00017719};
GN Name=rne {ECO:0000313|EMBL:AAU28359.1};
GN OrderedLocusNames=lpg2297 {ECO:0000313|EMBL:AAU28359.1};
OS Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC
OS 33152 / DSM 7513).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales;
OC Legionellaceae; Legionella.
OX NCBI_TaxID=272624 {ECO:0000313|EMBL:AAU28359.1, ECO:0000313|Proteomes:UP000000609};
RN [1] {ECO:0000313|EMBL:AAU28359.1, ECO:0000313|Proteomes:UP000000609}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Philadelphia 1 / ATCC 33152 / DSM 7513
RC {ECO:0000313|Proteomes:UP000000609};
RX PubMed=15448271; DOI=10.1126/science.1099776;
RA Chien M., Morozova I., Shi S., Sheng H., Chen J., Gomez S.M., Asamani G.,
RA Hill K., Nuara J., Feder M., Rineer J., Greenberg J.J., Steshenko V.,
RA Park S.H., Zhao B., Teplitskaya E., Edwards J.R., Pampou S., Georghiou A.,
RA Chou I.C., Iannuccilli W., Ulz M.E., Kim D.H., Geringer-Sameth A.,
RA Goldsberry C., Morozov P., Fischer S.G., Segal G., Qu X., Rzhetsky A.,
RA Zhang P., Cayanis E., De Jong P.J., Ju J., Kalachikov S., Shuman H.A.,
RA Russo J.J.;
RT "The genomic sequence of the accidental pathogen Legionella pneumophila.";
RL Science 305:1966-1968(2004).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the RNase E/G family. RNase G subfamily.
CC {ECO:0000256|ARBA:ARBA00005663}.
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DR EMBL; AE017354; AAU28359.1; -; Genomic_DNA.
DR RefSeq; YP_096306.1; NC_002942.5.
DR AlphaFoldDB; Q5ZT68; -.
DR STRING; 272624.lpg2297; -.
DR PaxDb; 272624-lpg2297; -.
DR KEGG; lpn:lpg2297; -.
DR PATRIC; fig|272624.6.peg.2410; -.
DR eggNOG; COG1530; Bacteria.
DR HOGENOM; CLU_003468_3_2_6; -.
DR OrthoDB; 9804278at2; -.
DR Proteomes; UP000000609; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004540; F:RNA nuclease activity; IEA:InterPro.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR CDD; cd04453; S1_RNase_E; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.1260.20; Ribonuclease E, catalytic domain; 1.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR019307; RNA-bd_AU-1/RNase_E/G.
DR InterPro; IPR004659; RNase_E/G.
DR InterPro; IPR048583; RNase_E_G_thioredoxin-like.
DR InterPro; IPR003029; S1_domain.
DR NCBIfam; TIGR00757; RNaseEG; 1.
DR PANTHER; PTHR30001; RIBONUCLEASE; 1.
DR PANTHER; PTHR30001:SF1; RIBONUCLEASE E_G-LIKE PROTEIN, CHLOROPLASTIC; 1.
DR Pfam; PF10150; RNase_E_G; 1.
DR Pfam; PF20833; RNase_E_G_Thio; 1.
DR Pfam; PF00575; S1; 1.
DR SMART; SM00316; S1; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR PROSITE; PS50126; S1; 1.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:AAU28359.1};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000000609};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 43..125
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT REGION 496..528
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 564..667
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 581..648
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 649..667
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 667 AA; 74883 MW; 7477B85DD023AD7E CRC64;
MGLYMEKMLI NAMQTEEIRV ALIKNNQLFD LDIECPGEIK KKGNIYKAIV TRREPSLDAV
FVEYGSKRQG FLPLKEIAPE YLSKNPEEFG DEKPPITSLI REGQELLIQV DKEERGNKGA
ALTTFITLAG CYLVLMPNNP HSGGISRRIE GDERDELRET LNALTLPEDM GLIIRTAGVG
KSLEELQDDL NMLCNQWQSI KEAYNSELAP CLIHQEGDVI IRSIRDNLRK SISEIIIDDQ
ISYIKAKQYI ERVKPEFLPN LKLYNSSIPL FNFYQIESQI ETAYQRQVML PSGGALVIDR
TEALVSIDIN SAKATGGADI EATALNTNLE AADEIARQLR LRDLGGLVVI DFIDMSSSKN
QREVENRLKE ALQADRARIQ VGRISRFGLL EMSRQRLRLS LGETAQEICP RCEGRGTVRS
IQSHGLSITR LIEEEALKEK TAEIQVQLPP EMATFIMNEK RNFIRDIEKR HGVSVVVIAN
PYMHPPQYTI TRLKEDNVGK SKKPSYSLIQ QPEVHVPSSD KEPVSHDEPA VKSFAEHRVI
KHPQTSFIKR LWTSLFGGHS VAHTVTQEPG KKHHRAQNQG KHASSKSSGG DKRQQGSNAN
RRRRSGGGQQ RSSSGNTNAA ASTHQQRKKS NANQQSHGSQ QSNRSIPAKN EGNKKREAIL
AKEPEEK
//
