ID Q5ZU85_LEGPH Unreviewed; 666 AA.
AC Q5ZU85;
DT 23-NOV-2004, integrated into UniProtKB/TrEMBL.
DT 23-NOV-2004, sequence version 1.
DT 27-MAR-2024, entry version 92.
DE SubName: Full=ATP dependent DNA helicase (DEAD box family) Rad3 {ECO:0000313|EMBL:AAU27992.1};
GN OrderedLocusNames=lpg1922 {ECO:0000313|EMBL:AAU27992.1};
OS Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC
OS 33152 / DSM 7513).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales;
OC Legionellaceae; Legionella.
OX NCBI_TaxID=272624 {ECO:0000313|EMBL:AAU27992.1, ECO:0000313|Proteomes:UP000000609};
RN [1] {ECO:0000313|EMBL:AAU27992.1, ECO:0000313|Proteomes:UP000000609}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Philadelphia 1 / ATCC 33152 / DSM 7513
RC {ECO:0000313|Proteomes:UP000000609};
RX PubMed=15448271; DOI=10.1126/science.1099776;
RA Chien M., Morozova I., Shi S., Sheng H., Chen J., Gomez S.M., Asamani G.,
RA Hill K., Nuara J., Feder M., Rineer J., Greenberg J.J., Steshenko V.,
RA Park S.H., Zhao B., Teplitskaya E., Edwards J.R., Pampou S., Georghiou A.,
RA Chou I.C., Iannuccilli W., Ulz M.E., Kim D.H., Geringer-Sameth A.,
RA Goldsberry C., Morozov P., Fischer S.G., Segal G., Qu X., Rzhetsky A.,
RA Zhang P., Cayanis E., De Jong P.J., Ju J., Kalachikov S., Shuman H.A.,
RA Russo J.J.;
RT "The genomic sequence of the accidental pathogen Legionella pneumophila.";
RL Science 305:1966-1968(2004).
CC -!- SIMILARITY: Belongs to the helicase family. DinG subfamily.
CC {ECO:0000256|ARBA:ARBA00038058}.
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DR EMBL; AE017354; AAU27992.1; -; Genomic_DNA.
DR RefSeq; YP_095939.1; NC_002942.5.
DR AlphaFoldDB; Q5ZU85; -.
DR STRING; 272624.lpg1922; -.
DR PaxDb; 272624-lpg1922; -.
DR KEGG; lpn:lpg1922; -.
DR PATRIC; fig|272624.6.peg.2007; -.
DR eggNOG; COG1199; Bacteria.
DR HOGENOM; CLU_012117_2_0_6; -.
DR OrthoDB; 9805194at2; -.
DR Proteomes; UP000000609; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016818; F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006139; P:nucleobase-containing compound metabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR006555; ATP-dep_Helicase_C.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR045028; DinG/Rad3-like.
DR InterPro; IPR014013; Helic_SF1/SF2_ATP-bd_DinG/Rad3.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010614; RAD3-like_helicase_DEAD.
DR PANTHER; PTHR11472; DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER; 1.
DR PANTHER; PTHR11472:SF47; FANCONI ANEMIA GROUP J PROTEIN; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF06733; DEAD_2; 1.
DR Pfam; PF13307; Helicase_C_2; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00491; HELICc2; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51193; HELICASE_ATP_BIND_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:AAU27992.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000000609}.
FT DOMAIN 34..302
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51193"
SQ SEQUENCE 666 AA; 74681 MW; 4FC34C7035A1F4C2 CRC64;
MGRSKGQTSI FAKRVEEITT FAETCRRTLS EKGRLSTAIP GFVARAPQAD LAVAIANAIV
QRSILVAEAG TGTGKTFAYL LPCLLSGKKA LISTATKTLQ DQLFQKDLPT LIRALGLSVR
IQNLKGRSNY ICQYRVEKHA EEGQFQSPQC AHEILHVRDK LSQMQEGVRS ELPEINEDSS
VWHYVTSTTD NCLGAECPNH ETCFLVKARK RAMEADIVVI NHHLFFADSQ LKKDGFSELL
PGVDVVVFDE AHQLADIASN FNGERLGTRQ FKDLVDDMLN EWPILDLANQ PLKSISHKAD
KLVDQLLNAL PTREERISWD LVKRNKEFME AWNTWLSLKD ELIQCLESKD TADIPGLKRC
KERLLDLETV LLSFTEENNH KIRWIERFKH TLVFHATPYD VAESFSQLLK DQSCAYIFTS
ATLTMASVFD SFCKPLGLDK VQTLLLSSPF DYQQQALLYL PRGIPDPKDA HYYEALLEKA
LPVIEACGGR CFFLFTSHKA VKLVAQMMSN TLKYPLLIQG DEAKPILLSR FRQLGNAVLL
GTSTFWEGVD VKGEALSCVI IDKLPFANPV DPVIRGRMSY LKKKGLSGFD ELSLPNAVIA
LKQGVGRLIR DITDKGILMI ADPRLTGREY GRTILASLPG LPKTRDEEKV LHFIKELALN
DETVSD
//
