ID Q5ZYZ7_LEGPH Unreviewed; 202 AA.
AC Q5ZYZ7;
DT 23-NOV-2004, integrated into UniProtKB/TrEMBL.
DT 23-NOV-2004, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Murein hydrolase exporter, LrgA family protein {ECO:0000313|EMBL:AAU26321.1};
GN OrderedLocusNames=lpg0214 {ECO:0000313|EMBL:AAU26321.1};
OS Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC
OS 33152 / DSM 7513).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales;
OC Legionellaceae; Legionella.
OX NCBI_TaxID=272624 {ECO:0000313|EMBL:AAU26321.1, ECO:0000313|Proteomes:UP000000609};
RN [1] {ECO:0000313|EMBL:AAU26321.1, ECO:0000313|Proteomes:UP000000609}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Philadelphia 1 / ATCC 33152 / DSM 7513
RC {ECO:0000313|Proteomes:UP000000609};
RX PubMed=15448271; DOI=10.1126/science.1099776;
RA Chien M., Morozova I., Shi S., Sheng H., Chen J., Gomez S.M., Asamani G.,
RA Hill K., Nuara J., Feder M., Rineer J., Greenberg J.J., Steshenko V.,
RA Park S.H., Zhao B., Teplitskaya E., Edwards J.R., Pampou S., Georghiou A.,
RA Chou I.C., Iannuccilli W., Ulz M.E., Kim D.H., Geringer-Sameth A.,
RA Goldsberry C., Morozov P., Fischer S.G., Segal G., Qu X., Rzhetsky A.,
RA Zhang P., Cayanis E., De Jong P.J., Ju J., Kalachikov S., Shuman H.A.,
RA Russo J.J.;
RT "The genomic sequence of the accidental pathogen Legionella pneumophila.";
RL Science 305:1966-1968(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AE017354; AAU26321.1; -; Genomic_DNA.
DR RefSeq; YP_094268.1; NC_002942.5.
DR AlphaFoldDB; Q5ZYZ7; -.
DR STRING; 272624.lpg0214; -.
DR PaxDb; 272624-lpg0214; -.
DR KEGG; lpn:lpg0214; -.
DR PATRIC; fig|272624.6.peg.227; -.
DR eggNOG; COG1380; Bacteria.
DR HOGENOM; CLU_113736_3_1_6; -.
DR OrthoDB; 194658at2; -.
DR Proteomes; UP000000609; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR InterPro; IPR005538; LrgA/CidA.
DR PANTHER; PTHR33931:SF2; HOLIN-LIKE PROTEIN CIDA; 1.
DR PANTHER; PTHR33931; HOLIN-LIKE PROTEIN CIDA-RELATED; 1.
DR Pfam; PF03788; LrgA; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Hydrolase {ECO:0000313|EMBL:AAU26321.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000609};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 37..57
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 78..95
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 107..126
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 138..155
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 167..190
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 202 AA; 23333 MW; 03604D1DF5B3FDBB CRC64;
MFYGFTDCRL GRKEIFSRFG KTTLPYNLYE SLKQFKFHNY SILERLLVYK FILFILIKSV
NLNEKIISTM STYMANKIQQ NSFFQIVLVG LFWLASELLL KLVKLPLSGG ILGLGIVLLL
LATNCLKLNR IRRGAELLLA NMLLFFIPGV LAILEHREFI GLLGLKILFI ILLSTITVML
VTALVVDYCY RWRTHHAKQH SL
//
