ID Q5ZZH8_LEGPH Unreviewed; 397 AA.
AC Q5ZZH8;
DT 23-NOV-2004, integrated into UniProtKB/TrEMBL.
DT 23-NOV-2004, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Leucine aminopeptidase {ECO:0000313|EMBL:AAU26140.1};
GN OrderedLocusNames=lpg0032 {ECO:0000313|EMBL:AAU26140.1};
OS Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC
OS 33152 / DSM 7513).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales;
OC Legionellaceae; Legionella.
OX NCBI_TaxID=272624 {ECO:0000313|EMBL:AAU26140.1, ECO:0000313|Proteomes:UP000000609};
RN [1] {ECO:0000313|EMBL:AAU26140.1, ECO:0000313|Proteomes:UP000000609}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Philadelphia 1 / ATCC 33152 / DSM 7513
RC {ECO:0000313|Proteomes:UP000000609};
RX PubMed=15448271; DOI=10.1126/science.1099776;
RA Chien M., Morozova I., Shi S., Sheng H., Chen J., Gomez S.M., Asamani G.,
RA Hill K., Nuara J., Feder M., Rineer J., Greenberg J.J., Steshenko V.,
RA Park S.H., Zhao B., Teplitskaya E., Edwards J.R., Pampou S., Georghiou A.,
RA Chou I.C., Iannuccilli W., Ulz M.E., Kim D.H., Geringer-Sameth A.,
RA Goldsberry C., Morozov P., Fischer S.G., Segal G., Qu X., Rzhetsky A.,
RA Zhang P., Cayanis E., De Jong P.J., Ju J., Kalachikov S., Shuman H.A.,
RA Russo J.J.;
RT "The genomic sequence of the accidental pathogen Legionella pneumophila.";
RL Science 305:1966-1968(2004).
RN [2] {ECO:0007829|PDB:5GNE}
RP X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 24-397, AND DISULFIDE BONDS.
RX PubMed=28776986; DOI=10.1021/acs.jafc.7b02849;
RA Zhang N., Yin S., Zhang W., Gong X., Zhang N., Fang K., Ge H.;
RT "Crystal Structure and Biochemical Characterization of an Aminopeptidase
RT LapB from Legionella pneumophila.";
RL J. Agric. Food Chem. 65:7569-7578(2017).
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DR EMBL; AE017354; AAU26140.1; -; Genomic_DNA.
DR RefSeq; WP_010945794.1; NC_002942.5.
DR RefSeq; YP_094087.1; NC_002942.5.
DR PDB; 5GNE; X-ray; 2.50 A; A/B=24-397.
DR PDBsum; 5GNE; -.
DR AlphaFoldDB; Q5ZZH8; -.
DR SMR; Q5ZZH8; -.
DR STRING; 272624.lpg0032; -.
DR PaxDb; 272624-lpg0032; -.
DR DNASU; 3078295; -.
DR GeneID; 66489235; -.
DR KEGG; lpn:lpg0032; -.
DR PATRIC; fig|272624.6.peg.33; -.
DR eggNOG; COG2234; Bacteria.
DR HOGENOM; CLU_025866_1_1_6; -.
DR OrthoDB; 9789219at2; -.
DR Proteomes; UP000000609; Chromosome.
DR GO; GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008235; F:metalloexopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR045175; M28_fam.
DR InterPro; IPR007484; Peptidase_M28.
DR PANTHER; PTHR12147:SF26; ENDOPLASMIC RETICULUM METALLOPEPTIDASE 1; 1.
DR PANTHER; PTHR12147; METALLOPEPTIDASE M28 FAMILY MEMBER; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:5GNE};
KW Aminopeptidase {ECO:0000313|EMBL:AAU26140.1};
KW Hydrolase {ECO:0000313|EMBL:AAU26140.1};
KW Metal-binding {ECO:0007829|PDB:5GNE};
KW Protease {ECO:0000313|EMBL:AAU26140.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000609};
KW Zinc {ECO:0007829|PDB:5GNE}.
FT DOMAIN 196..389
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
FT BINDING 213
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0007829|PDB:5GNE"
FT BINDING 226
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0007829|PDB:5GNE"
FT BINDING 226
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0007829|PDB:5GNE"
FT BINDING 260
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0007829|PDB:5GNE"
FT BINDING 260
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0007829|PDB:5GNE"
FT BINDING 261
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0007829|PDB:5GNE"
FT BINDING 288
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0007829|PDB:5GNE"
FT BINDING 366
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0007829|PDB:5GNE"
FT DISULFID 37..77
FT /evidence="ECO:0007829|PDB:5GNE"
FT DISULFID 333..337
FT /evidence="ECO:0007829|PDB:5GNE"
SQ SEQUENCE 397 AA; 44721 MW; 60494DDE49EE21A4 CRC64;
MVFKSRLVGI ILLCFSSITG WCLSQSPEED RIIVSNCLYE QLKDKARLIA QSDHFSFIAI
PIDENITNTL QKMRPVCGNY LNAEPYIQQT SNRFLDSKKL LDKLTSYHSI STANPYPINH
EAQVHSLFEQ IDPAKIWQTN QHLTSYINRS AKSRTGVEAA QWFKQQFDTL AQDYGRKDVE
SYFVKTGNKF IQPSVVTVIG KDKPGEAIVI GAHIDTLDGN MPGADDDSSG ISVELEMARV
VFSSNFELNR PIYFIAYAAE ERGLIGSGYV VQDFLQKKIP VKAVMQLDQA GYRANAKDQT
IWLLKDYVDK GLTEFTAELL TRYVKTPVGY TKCGYACSDH VNWTNEGFKT TYPSATTLDD
DNPYVHTSND TLDILNLEHM VNFTKLGLAF IVELGLN
//
