GenomeNet

Database: UniProt
Entry: Q60438
LinkDB: Q60438
Original site: Q60438 
ID   CREL2_CRIGR             Reviewed;         348 AA.
AC   Q60438;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   10-APR-2019, entry version 91.
DE   RecName: Full=Cysteine-rich with EGF-like domain protein 2;
DE   AltName: Full=Protein HT;
DE   Flags: Precursor;
GN   Name=CRELD2;
OS   Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Cricetidae; Cricetinae; Cricetulus.
OX   NCBI_TaxID=10029;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Chen H., Okubo T., Ling V., Zhang W.;
RL   Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May regulate transport of alpha4-beta2 neuronal
CC       acetylcholine receptor. {ECO:0000250}.
CC   -!- SUBUNIT: May interact with CHRNA4. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted. Endoplasmic reticulum
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CRELD family. {ECO:0000305}.
DR   EMBL; U48852; AAA91469.1; -; mRNA.
DR   RefSeq; NP_001231065.1; NM_001244136.1.
DR   ProteinModelPortal; Q60438; -.
DR   STRING; 10029.NP_001231065.1; -.
DR   PRIDE; Q60438; -.
DR   GeneID; 100689097; -.
DR   KEGG; cge:100689097; -.
DR   CTD; 79174; -.
DR   HOVERGEN; HBG081344; -.
DR   OrthoDB; 883628at2759; -.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   CDD; cd00064; FU; 2.
DR   InterPro; IPR021852; DUF3456.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR006212; Furin_repeat.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR002049; Laminin_EGF.
DR   Pfam; PF11938; DUF3456; 1.
DR   Pfam; PF07645; EGF_CA; 1.
DR   SMART; SM00181; EGF; 3.
DR   SMART; SM00179; EGF_CA; 2.
DR   SMART; SM00261; FU; 2.
DR   SUPFAM; SSF57184; SSF57184; 1.
DR   PROSITE; PS00010; ASX_HYDROXYL; 1.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS01186; EGF_2; 2.
DR   PROSITE; PS50026; EGF_3; 2.
DR   PROSITE; PS01187; EGF_CA; 2.
PE   2: Evidence at transcript level;
KW   Calcium; Disulfide bond; EGF-like domain; Endoplasmic reticulum;
KW   Glycoprotein; Repeat; Secreted; Signal.
FT   SIGNAL        1     22       {ECO:0000255}.
FT   CHAIN        23    348       Cysteine-rich with EGF-like domain
FT                                protein 2.
FT                                /FTId=PRO_0000256245.
FT   DOMAIN      135    177       EGF-like 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   REPEAT      192    239       FU 1.
FT   REPEAT      252    299       FU 2.
FT   DOMAIN      289    329       EGF-like 2; calcium-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   CARBOHYD    250    250       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID    139    153       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    147    165       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    167    176       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    293    307       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    300    316       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    318    328       {ECO:0000255|PROSITE-ProRule:PRU00076}.
SQ   SEQUENCE   348 AA;  38199 MW;  BD61F6C89971BB6D CRC64;
     MHLPPAAAVG LLLLLLPPPA RVASRKPTMC QRCRALVDKF NQGMANTARK NFGGGNTAWE
     EKSLSKYEFS EIRLLEIMEG LCDSNDFECN QLLEQHEEQL EAWWQTLKKE CPNLFEWFCV
     HTLKACCLPG TYGPDCQECQ GGSQRPCSGN GHCDGDGSRQ GDGSCQCHVG YKGPLCIDCM
     DGYFSLLRNE THSFCTACDE SCKTCSGPTN KGCVECEVGW TRVEDACVDV DECAAETPPC
     SNVQYCENVN GSYTCEECDS TCVGCTGKGP ANCKECISGY SKQKGECADI DECSLETKVC
     KKENENCYNT PGSFVCVCPE GFEEDRRCLC TDSRRRSGRG KSHTATLP
//
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