ID FBXW2_MOUSE Reviewed; 422 AA.
AC Q60584; E9PXP3;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 2.
DT 27-MAR-2024, entry version 156.
DE RecName: Full=F-box/WD repeat-containing protein 2;
DE AltName: Full=F-box and WD-40 domain-containing protein 2;
DE AltName: Full=Protein MD6;
GN Name=Fbxw2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ; TISSUE=Heart;
RX PubMed=1296816; DOI=10.3109/10425179209034020;
RA Duff K.E.K., Parsons J., Hodgman T.C.;
RT "Secondary structure analysis identifies a putative mouse protein
RT demonstrating similarity to the repeat units found in CDC4, the G protein
RT beta subunits and related proteins.";
RL DNA Seq. 3:213-220(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=10531037; DOI=10.1016/s0960-9822(00)80021-4;
RA Winston J.T., Koepp D.M., Zhu C., Elledge S.J., Harper J.W.;
RT "A family of mammalian F-box proteins.";
RL Curr. Biol. 9:1180-1182(1999).
CC -!- FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box
CC protein)-type E3 ubiquitin ligase complex.
CC -!- SUBUNIT: Directly interacts with SKP1 and CUL1. {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Widely expressed during embryogenesis and in adult
CC tissues. {ECO:0000269|PubMed:10531037}.
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DR EMBL; X54352; CAA38237.1; -; mRNA.
DR EMBL; AL929106; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PIR; A56640; A56640.
DR AlphaFoldDB; Q60584; -.
DR SMR; Q60584; -.
DR STRING; 10090.ENSMUSP00000028220; -.
DR iPTMnet; Q60584; -.
DR PhosphoSitePlus; Q60584; -.
DR MaxQB; Q60584; -.
DR PaxDb; 10090-ENSMUSP00000108703; -.
DR ProteomicsDB; 267719; -.
DR UCSC; uc008jja.2; mouse.
DR AGR; MGI:1353435; -.
DR MGI; MGI:1353435; Fbxw2.
DR eggNOG; KOG0274; Eukaryota.
DR InParanoid; Q60584; -.
DR Reactome; R-MMU-8951664; Neddylation.
DR Reactome; R-MMU-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR ChiTaRS; Fbxw2; mouse.
DR PRO; PR:Q60584; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q60584; Protein.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR CDD; cd22131; F-box_FBXW2; 1.
DR Gene3D; 1.20.1280.50; -; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR042627; FBXW2.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR44436; F-BOX/WD REPEAT-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR44436:SF1; F-BOX_WD REPEAT-CONTAINING PROTEIN 2; 1.
DR Pfam; PF12937; F-box-like; 1.
DR Pfam; PF00400; WD40; 3.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00256; FBOX; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF81383; F-box domain; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50181; FBOX; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Reference proteome; Repeat; Ubl conjugation pathway;
KW WD repeat.
FT CHAIN 1..422
FT /note="F-box/WD repeat-containing protein 2"
FT /id="PRO_0000050989"
FT DOMAIN 54..101
FT /note="F-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT REPEAT 146..183
FT /note="WD 1"
FT REPEAT 185..221
FT /note="WD 2"
FT REPEAT 224..265
FT /note="WD 3"
FT REPEAT 276..314
FT /note="WD 4"
FT MOD_RES 298
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q9UKT8"
FT CONFLICT 21
FT /note="T -> M (in Ref. 1; CAA38237)"
FT /evidence="ECO:0000305"
FT CONFLICT 87
FT /note="W -> R (in Ref. 1; CAA38237)"
FT /evidence="ECO:0000305"
FT CONFLICT 413
FT /note="S -> T (in Ref. 1; CAA38237)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 422 AA; 47896 MW; F3E4C8FE01309CAE CRC64;
MERKDFETWL DNISVTFLSL TDLQKNETLD HLISLSGAVQ LRHLSNNLET LLKRDFLKLL
PLELSFYLLK WLDPQTLLTC CLVSKQWNKV ISACTEVWQT ACKNLGWQID DSVQDSLHWK
KVYLKAILRM KQLEDHEAFE TSSLIGHSAR VYALYYKDGL LCTGSDDLSA KLWDVSTGQC
VYGIQTHTCA AVKFDEQKLV TGSFDNTVAC WEWSSGARTQ HFRGHTGAVF SVDYSDELDI
LVSGSADFAV KVWALSAGTC LNTLTGHTEW VTKVVLQKCK VKSLLHSPGD YILLSADKYE
IKIWPIGREI NCKCLKTLSV SEDRSICLQP RLHFDGKYIV CSSALGLYQW DFASYDILRV
IKTPEVANLA LLGFGDVFAL LFDNHYLYIM DLRTESLISR WPLPEYRKSK RGSSFLAGER
PG
//
