ID Q60BG9_METCA Unreviewed; 286 AA.
AC Q60BG9;
DT 23-NOV-2004, integrated into UniProtKB/TrEMBL.
DT 23-NOV-2004, sequence version 1.
DT 27-MAR-2024, entry version 101.
DE SubName: Full=Methylenetetrahydromethanopterin dehydrogenase/methylenetetrahydrofolate dehydrogenase {ECO:0000313|EMBL:AAU93303.1};
DE EC=1.5.1.5 {ECO:0000313|EMBL:AAU93303.1};
GN OrderedLocusNames=MCA0508 {ECO:0000313|EMBL:AAU93303.1};
OS Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Methylococcales;
OC Methylococcaceae; Methylococcus.
OX NCBI_TaxID=243233 {ECO:0000313|EMBL:AAU93303.1, ECO:0000313|Proteomes:UP000006821};
RN [1] {ECO:0000313|EMBL:AAU93303.1, ECO:0000313|Proteomes:UP000006821}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33009 / NCIMB 11132 / Bath
RC {ECO:0000313|Proteomes:UP000006821};
RX PubMed=15383840; DOI=10.1371/journal.pbio.0020303;
RA Ward N.L., Larsen O., Sakwa J., Bruseth L., Khouri H.M., Durkin A.S.,
RA Dimitrov G., Jiang L., Scanlan D., Kang K.H., Lewis M.R., Nelson K.E.,
RA Methe B.A., Wu M., Heidelberg J.F., Paulsen I.T., Fouts D.E., Ravel J.,
RA Tettelin H., Ren Q., Read T.D., DeBoy R.T., Seshadri R., Salzberg S.L.,
RA Jensen H.B., Birkeland N.K., Nelson W.C., Dodson R.J., Grindhaug S.H.,
RA Holt I.E., Eidhammer I., Jonasen I., Vanaken S., Utterback T.R.,
RA Feldblyum T.V., Fraser C.M., Lillehaug J.R., Eisen J.A.;
RT "Genomic insights into methanotrophy: the complete genome sequence of
RT Methylococcus capsulatus (Bath).";
RL PLoS Biol. 2:1616-1628(2004).
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DR EMBL; AE017282; AAU93303.1; -; Genomic_DNA.
DR RefSeq; WP_010959856.1; NC_002977.6.
DR AlphaFoldDB; Q60BG9; -.
DR STRING; 243233.MCA0508; -.
DR KEGG; mca:MCA0508; -.
DR eggNOG; COG0373; Bacteria.
DR HOGENOM; CLU_059363_0_0_6; -.
DR Proteomes; UP000006821; Chromosome.
DR GO; GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; ISS:JCVI.
DR GO; GO:0030268; F:methylenetetrahydromethanopterin dehydrogenase activity; ISS:JCVI.
DR GO; GO:0019496; P:serine-isocitrate lyase pathway; ISS:JCVI.
DR CDD; cd01078; NAD_bind_H4MPT_DH; 1.
DR Gene3D; 3.40.50.10280; Methylene-tetrahydromethanopterin dehydrogenase, N-terminal domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR InterPro; IPR015259; Methyl-teptahyd_DH_N.
DR InterPro; IPR037089; Methyl-teptahyd_DH_N_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR035015; NAD-bd_H4MPT_DH.
DR InterPro; IPR006151; Shikm_DH/Glu-tRNA_Rdtase.
DR Pfam; PF09176; Mpt_N; 1.
DR Pfam; PF01488; Shikimate_DH; 1.
DR SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:AAU93303.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006821}.
FT DOMAIN 16..96
FT /note="Methylene-tetrahydromethanopterin dehydrogenase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF09176"
FT DOMAIN 118..196
FT /note="Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA
FT reductase"
FT /evidence="ECO:0000259|Pfam:PF01488"
SQ SEQUENCE 286 AA; 30265 MW; 2FABE748B753E349 CRC64;
MKKLLFQFDT DLHPSVFDTV VGYDGGADQV IAHGHLTPDN VGPLVEGTIF TRAPKDKKNT
AIFVGGSDLV AGQNLLRAVR KKFFADFRVS VMLDSNGSNT TAAAGVAKLA SSGTLAGKKA
VVLAGTGPVG QRAAVMLAKE GCSEVVITSR QMARAEHACA EMKARFGVDL VPVEAFDDDA
RAAAIADAQI VFATGAAGVR LLEECHWRDR PDLELLADAN ATPPLGLGGT DMMDRGTDRH
GKIVWGAIGF GTLKLAVHRA CIAKLFERND QVFDAEEIFA LAKTMA
//
