ID Q60BP5_METCA Unreviewed; 70 AA.
AC Q60BP5;
DT 23-NOV-2004, integrated into UniProtKB/TrEMBL.
DT 23-NOV-2004, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=Heme exporter protein D {ECO:0000256|ARBA:ARBA00016461, ECO:0000256|RuleBase:RU363101};
GN OrderedLocusNames=MCA0420 {ECO:0000313|EMBL:AAU90412.1};
OS Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Methylococcales;
OC Methylococcaceae; Methylococcus.
OX NCBI_TaxID=243233 {ECO:0000313|EMBL:AAU90412.1, ECO:0000313|Proteomes:UP000006821};
RN [1] {ECO:0000313|EMBL:AAU90412.1, ECO:0000313|Proteomes:UP000006821}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33009 / NCIMB 11132 / Bath
RC {ECO:0000313|Proteomes:UP000006821};
RX PubMed=15383840; DOI=10.1371/journal.pbio.0020303;
RA Ward N.L., Larsen O., Sakwa J., Bruseth L., Khouri H.M., Durkin A.S.,
RA Dimitrov G., Jiang L., Scanlan D., Kang K.H., Lewis M.R., Nelson K.E.,
RA Methe B.A., Wu M., Heidelberg J.F., Paulsen I.T., Fouts D.E., Ravel J.,
RA Tettelin H., Ren Q., Read T.D., DeBoy R.T., Seshadri R., Salzberg S.L.,
RA Jensen H.B., Birkeland N.K., Nelson W.C., Dodson R.J., Grindhaug S.H.,
RA Holt I.E., Eidhammer I., Jonasen I., Vanaken S., Utterback T.R.,
RA Feldblyum T.V., Fraser C.M., Lillehaug J.R., Eisen J.A.;
RT "Genomic insights into methanotrophy: the complete genome sequence of
RT Methylococcus capsulatus (Bath).";
RL PLoS Biol. 2:1616-1628(2004).
CC -!- FUNCTION: Required for the export of heme to the periplasm for the
CC biogenesis of c-type cytochromes. {ECO:0000256|ARBA:ARBA00002442,
CC ECO:0000256|RuleBase:RU363101}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004377, ECO:0000256|RuleBase:RU363101}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004377,
CC ECO:0000256|RuleBase:RU363101}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the CcmD/CycX/HelD family.
CC {ECO:0000256|ARBA:ARBA00008741, ECO:0000256|RuleBase:RU363101}.
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DR EMBL; AE017282; AAU90412.1; -; Genomic_DNA.
DR AlphaFoldDB; Q60BP5; -.
DR STRING; 243233.MCA0420; -.
DR KEGG; mca:MCA0420; -.
DR eggNOG; COG3114; Bacteria.
DR HOGENOM; CLU_180892_1_1_6; -.
DR Proteomes; UP000006821; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015232; F:heme transmembrane transporter activity; ISS:JCVI.
DR GO; GO:0017004; P:cytochrome complex assembly; IEA:UniProtKB-KW.
DR GO; GO:0015886; P:heme transport; ISS:JCVI.
DR InterPro; IPR007078; Haem_export_protD_CcmD.
DR NCBIfam; TIGR03141; cytochro_ccmD; 1.
DR PANTHER; PTHR37531; HEME EXPORTER PROTEIN D; 1.
DR PANTHER; PTHR37531:SF1; HEME EXPORTER PROTEIN D; 1.
DR Pfam; PF04995; CcmD; 1.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|RuleBase:RU363101};
KW Cell membrane {ECO:0000256|RuleBase:RU363101};
KW Cytochrome c-type biogenesis {ECO:0000256|RuleBase:RU363101};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363101};
KW Reference proteome {ECO:0000313|Proteomes:UP000006821};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU363101};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU363101}; Transport {ECO:0000256|RuleBase:RU363101}.
FT TRANSMEM 27..48
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363101"
SQ SEQUENCE 70 AA; 8242 MW; FCA71DFB86C3C8A1 CRC64;
MSIPISPSSE AFLKHMNFQE FFHMGGYAVY VWTSYGLCFA VLVFNLITPL RRKNEMLKSL
RRQLKQESRP
//
