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Database: UniProt
Entry: Q61983
LinkDB: Q61983
Original site: Q61983 
ID   NPT1_MOUSE              Reviewed;         465 AA.
AC   Q61983; A9Z1Z4; Q91YA1;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 2.
DT   27-MAR-2024, entry version 162.
DE   RecName: Full=Sodium-dependent phosphate transport protein 1;
DE   AltName: Full=Na(+)/PI cotransporter 1;
DE   AltName: Full=Renal Na(+)-dependent phosphate cotransporter 1;
DE   AltName: Full=Renal sodium-dependent phosphate transport protein 1;
DE            Short=Renal sodium-phosphate transport protein 1;
DE   AltName: Full=Sodium/phosphate cotransporter 1;
DE   AltName: Full=Solute carrier family 17 member 1;
GN   Name=Slc17a1; Synonyms=Npt1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Kidney;
RX   PubMed=7611445; DOI=10.1152/ajprenal.1995.268.6.f1038;
RA   Chong S.S., Kozak C.A., Liu L., Kristjansson K., Dunn S.T., Bourdeau J.E.,
RA   Hughes M.R.;
RT   "Cloning, genetic mapping, and expression analysis of a mouse renal sodium-
RT   dependent phosphate cotransporter.";
RL   Am. J. Physiol. 268:F1038-F1045(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-148.
RC   STRAIN=129/SvJ;
RX   PubMed=11704559; DOI=10.1152/ajprenal.0092.2001;
RA   Soumounou Y., Gauthier C., Tenenhouse H.S.;
RT   "Murine and human type I Na-phosphate cotransporter genes: structure and
RT   promoter activity.";
RL   Am. J. Physiol. 281:F1082-F1091(2001).
RN   [4]
RP   INTERACTION WITH PDZK1.
RX   PubMed=11099500; DOI=10.1074/jbc.m008745200;
RA   Gisler S.M., Stagljar I., Traebert M., Bacic D., Biber J., Murer H.;
RT   "Interaction of the type IIa Na/Pi-cotransporter with PDZ proteins.";
RL   J. Biol. Chem. 276:9206-9213(2001).
CC   -!- FUNCTION: Important for the resorption of phosphate by the kidney. May
CC       be involved in actively transporting phosphate into cells via Na(+)
CC       cotransport in the renal brush border membrane. Plays a role in urate
CC       transport in the kidney. {ECO:0000250|UniProtKB:Q14916}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3 Na(+)(out) + phosphate(out) = 3 Na(+)(in) + phosphate(in);
CC         Xref=Rhea:RHEA:71255, ChEBI:CHEBI:29101, ChEBI:CHEBI:43474;
CC         Evidence={ECO:0000250|UniProtKB:Q14916};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=urate(out) = urate(in); Xref=Rhea:RHEA:60368,
CC         ChEBI:CHEBI:17775; Evidence={ECO:0000250|UniProtKB:Q14916};
CC   -!- SUBUNIT: Interacts with PDZK1. {ECO:0000269|PubMed:11099500}.
CC   -!- SUBCELLULAR LOCATION: Apical cell membrane
CC       {ECO:0000250|UniProtKB:Q14916}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- TISSUE SPECIFICITY: Kidney. {ECO:0000269|PubMed:7611445}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Sodium/anion
CC       cotransporter family. {ECO:0000305}.
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DR   EMBL; X77241; CAA54459.1; -; mRNA.
DR   EMBL; AL590388; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL606464; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AF361768; AAK97542.1; -; Genomic_DNA.
DR   EMBL; AF361764; AAK97542.1; JOINED; Genomic_DNA.
DR   EMBL; AF361766; AAK97542.1; JOINED; Genomic_DNA.
DR   CCDS; CCDS26372.1; -.
DR   PIR; S69915; S69915.
DR   RefSeq; NP_001164109.1; NM_001170638.1.
DR   RefSeq; NP_033224.3; NM_009198.3.
DR   AlphaFoldDB; Q61983; -.
DR   SMR; Q61983; -.
DR   IntAct; Q61983; 4.
DR   MINT; Q61983; -.
DR   STRING; 10090.ENSMUSP00000006785; -.
DR   TCDB; 2.A.1.14.6; the major facilitator superfamily (mfs).
DR   GlyCosmos; Q61983; 3 sites, No reported glycans.
DR   GlyGen; Q61983; 3 sites.
DR   iPTMnet; Q61983; -.
DR   PhosphoSitePlus; Q61983; -.
DR   jPOST; Q61983; -.
DR   PaxDb; 10090-ENSMUSP00000006785; -.
DR   ProteomicsDB; 293955; -.
DR   Antibodypedia; 25435; 104 antibodies from 21 providers.
DR   DNASU; 20504; -.
DR   Ensembl; ENSMUST00000006785.8; ENSMUSP00000006785.8; ENSMUSG00000021335.14.
DR   Ensembl; ENSMUST00000110413.8; ENSMUSP00000106043.2; ENSMUSG00000021335.14.
DR   GeneID; 20504; -.
DR   KEGG; mmu:20504; -.
DR   UCSC; uc007pvf.2; mouse.
DR   AGR; MGI:103209; -.
DR   CTD; 6568; -.
DR   MGI; MGI:103209; Slc17a1.
DR   VEuPathDB; HostDB:ENSMUSG00000021335; -.
DR   eggNOG; KOG2532; Eukaryota.
DR   GeneTree; ENSGT00940000162346; -.
DR   HOGENOM; CLU_001265_5_0_1; -.
DR   InParanoid; Q61983; -.
DR   OMA; RRTTWGM; -.
DR   OrthoDB; 2685946at2759; -.
DR   PhylomeDB; Q61983; -.
DR   TreeFam; TF313535; -.
DR   Reactome; R-MMU-428643; Organic anion transporters.
DR   BioGRID-ORCS; 20504; 5 hits in 77 CRISPR screens.
DR   ChiTaRS; Slc17a1; mouse.
DR   PRO; PR:Q61983; -.
DR   Proteomes; UP000000589; Chromosome 13.
DR   RNAct; Q61983; Protein.
DR   Bgee; ENSMUSG00000021335; Expressed in right kidney and 30 other cell types or tissues.
DR   ExpressionAtlas; Q61983; baseline and differential.
DR   Genevisible; Q61983; MM.
DR   GO; GO:0016324; C:apical plasma membrane; ISS:UniProtKB.
DR   GO; GO:0015114; F:phosphate ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0006820; P:monoatomic anion transport; IBA:GO_Central.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0044341; P:sodium-dependent phosphate transport; ISS:UniProtKB.
DR   GO; GO:0046415; P:urate metabolic process; ISO:MGI.
DR   GO; GO:0015747; P:urate transport; ISS:UniProtKB.
DR   CDD; cd17318; MFS_SLC17; 1.
DR   Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 2.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR004745; Pi_cotranspt.
DR   NCBIfam; TIGR00894; 2A0114euk; 1.
DR   PANTHER; PTHR11662:SF26; SODIUM-DEPENDENT PHOSPHATE TRANSPORT PROTEIN 1; 1.
DR   PANTHER; PTHR11662; SOLUTE CARRIER FAMILY 17; 1.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Glycoprotein; Ion transport; Membrane; Reference proteome;
KW   Sodium; Sodium transport; Symport; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..465
FT                   /note="Sodium-dependent phosphate transport protein 1"
FT                   /id="PRO_0000220937"
FT   TRANSMEM        79..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        117..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        176..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        199..219
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        260..280
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        304..324
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        337..356
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        363..383
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        399..419
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        429..449
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        39
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        47
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        56
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        123
FT                   /note="L -> I (in Ref. 1; CAA54459 and 3; AAK97542)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        431
FT                   /note="F -> S (in Ref. 1; CAA54459)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   465 AA;  51649 MW;  F60BF9F9C04F3A2D CRC64;
     MENQCLPKKV PGFCSFRYGL AILLHFCNIA IMAQRVCLNL TMVAMVNNTG SPHLSNESVV
     EMLDNVKNPV YSWSPDIQGL ILSSVFFGMV VVQAPVGYLS GIYPMKRIIG SSLFLSSLMS
     LLLPPAAQVG AALVIVCRVL QGIAQGTVST GQHEIWVKWA PPLERGRLTS MTLSGFVMGP
     FIVLLVSGFI CDLLGWPMVF YIFGIVGCVL SLSWFFLFFD DPKDHPYMSS SEKDYIISSL
     MQQASSGRQS LPIKAMLKSL PLWAIILNSF AFIWSNSLLV TYTPTFISTV LHVNVRENGL
     LSSLPYLLAY ICGILAGQMS DFFLTRKIFS IVTVRKLFTT LGSFCPVIFI MCLLYLSYNF
     YSTVIFLTLA NSTLSFSYCG QLINALDIAP RYYGFLKAVT ALIGMFGGLI SSTLAGLILN
     QDPEYAWHKI FFLMAGINVT CLVFYFLFAK GEIQDWAKEI KTTRL
//
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