ID NPY4R_RAT Reviewed; 375 AA.
AC Q63447; Q62892;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 24-JAN-2024, entry version 155.
DE RecName: Full=Neuropeptide Y receptor type 4;
DE Short=NPY4-R;
DE AltName: Full=Pancreatic polypeptide receptor 1;
DE Short=PP1;
GN Name=Npy4r; Synonyms=Ppyr1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION, AND
RP TISSUE SPECIFICITY.
RC STRAIN=Sprague-Dawley;
RX PubMed=8643536; DOI=10.1073/pnas.93.10.5111;
RA Lundell I., Statnick M.A., Johnson D., Schober D.A., Starback P.,
RA Gehlert D.R., Larhammar D.;
RT "The cloned rat pancreatic polypeptide receptor exhibits profound
RT differences to the orthologous receptor.";
RL Proc. Natl. Acad. Sci. U.S.A. 93:5111-5115(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8643460; DOI=10.1073/pnas.93.10.4661;
RA Yan H., Yang J., Marasco J., Yamaguchi K., Brenner S., Collins F.,
RA Karbon W.;
RT "Cloning and functional expression of cDNAs encoding human and rat
RT pancreatic polypeptide receptors.";
RL Proc. Natl. Acad. Sci. U.S.A. 93:4661-4665(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Wistar;
RX PubMed=9210181; DOI=10.1016/s0196-9781(97)00070-3;
RA Walker M.W., Smith K.E., Bard J., Vaysse P.J.-J., Gerald C., Daouti S.,
RA Weinshank R.L., Branchek T.A.;
RT "A structure-activity analysis of the cloned rat and human Y4 receptors for
RT pancreatic polypeptide.";
RL Peptides 18:609-612(1997).
CC -!- FUNCTION: G protein-coupled receptor for PPY/pancreatic polypeptide/PP
CC that is negatively coupled to cAMP (PubMed:8643536). Has much lower
CC affinity for the NPY/neuropeptide Y and PYY/peptide YY
CC (PubMed:8643536). {ECO:0000269|PubMed:8643536}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:8643536};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Detected in colon and brain.
CC {ECO:0000269|PubMed:8643536}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; Z68180; CAA92322.1; -; Genomic_DNA.
DR EMBL; U42388; AAB07761.1; -; mRNA.
DR EMBL; U84245; AAB87736.1; -; Genomic_DNA.
DR RefSeq; NP_113769.1; NM_031581.2.
DR AlphaFoldDB; Q63447; -.
DR SMR; Q63447; -.
DR STRING; 10116.ENSRNOP00000069607; -.
DR BindingDB; Q63447; -.
DR ChEMBL; CHEMBL4827; -.
DR GuidetoPHARMACOLOGY; 307; -.
DR GlyCosmos; Q63447; 4 sites, No reported glycans.
DR GlyGen; Q63447; 4 sites.
DR iPTMnet; Q63447; -.
DR PhosphoSitePlus; Q63447; -.
DR PaxDb; 10116-ENSRNOP00000027469; -.
DR Ensembl; ENSRNOT00000083105.2; ENSRNOP00000069607.1; ENSRNOG00000061026.2.
DR Ensembl; ENSRNOT00055018135; ENSRNOP00055014577; ENSRNOG00055010727.
DR Ensembl; ENSRNOT00060025160; ENSRNOP00060020052; ENSRNOG00060014726.
DR Ensembl; ENSRNOT00065027160; ENSRNOP00065021344; ENSRNOG00065016316.
DR GeneID; 29471; -.
DR KEGG; rno:29471; -.
DR UCSC; RGD:61864; rat.
DR AGR; RGD:61864; -.
DR CTD; 5540; -.
DR RGD; 61864; Npy4r.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00940000161927; -.
DR HOGENOM; CLU_009579_6_1_1; -.
DR InParanoid; Q63447; -.
DR OMA; FTVVYTM; -.
DR OrthoDB; 2995026at2759; -.
DR PhylomeDB; Q63447; -.
DR TreeFam; TF315303; -.
DR Reactome; R-RNO-375276; Peptide ligand-binding receptors.
DR Reactome; R-RNO-418594; G alpha (i) signalling events.
DR PRO; PR:Q63447; -.
DR Proteomes; UP000002494; Chromosome 16.
DR Bgee; ENSRNOG00000061026; Expressed in colon and 7 other cell types or tissues.
DR Genevisible; Q63447; RN.
DR GO; GO:0016020; C:membrane; ISO:RGD.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0042923; F:neuropeptide binding; IBA:GO_Central.
DR GO; GO:0001602; F:pancreatic polypeptide receptor activity; IDA:RGD.
DR GO; GO:0042277; F:peptide binding; IMP:RGD.
DR GO; GO:0017046; F:peptide hormone binding; ISO:RGD.
DR GO; GO:0001601; F:peptide YY receptor activity; ISO:RGD.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISO:RGD.
DR GO; GO:0007218; P:neuropeptide signaling pathway; ISO:RGD.
DR CDD; cd15397; 7tmA_NPY4R; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001933; NPY4_rcpt.
DR InterPro; IPR000611; NPY_rcpt.
DR PANTHER; PTHR24235; NEUROPEPTIDE Y RECEPTOR; 1.
DR PANTHER; PTHR24235:SF25; NEUROPEPTIDE Y RECEPTOR TYPE 4-RELATED; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01015; NRPEPTIDEY4R.
DR PRINTS; PR01012; NRPEPTIDEYR.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Lipoprotein; Membrane; Palmitate; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..375
FT /note="Neuropeptide Y receptor type 4"
FT /id="PRO_0000069937"
FT TOPO_DOM 1..39
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 40..60
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 61..78
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 100..116
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 138..155
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 156..176
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 177..211
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 212..232
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 233..262
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 263..283
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 284..301
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 302..322
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 323..375
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT LIPID 340
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 19
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 29
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 187
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 114..201
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 23
FT /note="P -> S (in Ref. 2; AAB07761)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 375 AA; 42568 MW; F8535C8C3EAD4FB9 CRC64;
MNTSHLMASL SPAFLQGKNG TNPLDSLYNL SDGCQDSADL LAFIITTYSV ETVLGVLGNL
CLIFVTTRQK EKSNVTNLLI ANLAFSDFLM CLICQPLTVT YTIMDYWIFG EVLCKMLTFI
QCMSVTVSIL SLVLVALERH QLIINPTGWK PSISQAYLGI VVIWFISCFL SLPFLANSIL
NDLFHYNHSK VVEFLEDKVV CFVSWSSDHH RLIYTTFLLL FQYCVPLAFI LVCYMRIYQR
LQRQRRAFHT HTCSSRVGQM KRINGMLMAM VTAFAVLWLP LHVFNTLEDW YQEAIPACHG
NLIFLMCHLF AMASTCVNPF IYGFLNINFK KDIKALVLTC RCRPPQGEPE PLPLSTVHTD
LSKGSMRMGS KSNVM
//
