ID   Q63P77_BURPS            Unreviewed;       731 AA.
AC   Q63P77;
DT   25-OCT-2004, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2004, sequence version 1.
DT   27-MAR-2024, entry version 88.
DE   RecName: Full=phospholipase C {ECO:0000256|ARBA:ARBA00012018};
DE            EC=3.1.4.3 {ECO:0000256|ARBA:ARBA00012018};
GN   OrderedLocusNames=BPSS0067 {ECO:0000313|EMBL:CAH37511.1};
OS   Burkholderia pseudomallei (strain K96243).
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; pseudomallei group.
OX   NCBI_TaxID=272560 {ECO:0000313|EMBL:CAH37511.1, ECO:0000313|Proteomes:UP000000605};
RN   [1] {ECO:0000313|EMBL:CAH37511.1, ECO:0000313|Proteomes:UP000000605}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K96243 {ECO:0000313|EMBL:CAH37511.1,
RC   ECO:0000313|Proteomes:UP000000605};
RX   PubMed=15377794; DOI=10.1073/pnas.0403302101;
RA   Holden M.T.G., Titball R.W., Peacock S.J., Cerdeno-Tarraga A.M., Atkins T.,
RA   Crossman L.C., Pitt T., Churcher C., Mungall K., Bentley S.D., Sebaihia M.,
RA   Thomson N.R., Bason N., Beacham I.R., Brooks K., Brown K.A., Brown N.F.,
RA   Challis G.L., Cherevach I., Chillingworth T., Cronin A., Crosset B.,
RA   Davis P., DeShazer D., Feltwell T., Fraser A., Hance Z., Hauser H.,
RA   Holroyd S., Jagels K., Keith K.E., Maddison M., Moule S., Price C.,
RA   Quail M.A., Rabbinowitsch E., Rutherford K., Sanders M., Simmonds M.,
RA   Songsivilai S., Stevens K., Tumapa S., Vesaratchavest M., Whitehead S.,
RA   Yeats C., Barrell B.G., Oyston P.C.F., Parkhill J.;
RT   "Genomic plasticity of the causative agent of melioidosis, Burkholderia
RT   pseudomallei.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:14240-14245(2004).
CC   -!- SIMILARITY: Belongs to the bacterial phospholipase C family.
CC       {ECO:0000256|ARBA:ARBA00009717}.
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DR   EMBL; BX571966; CAH37511.1; -; Genomic_DNA.
DR   RefSeq; WP_004544960.1; NZ_CP009537.1.
DR   RefSeq; YP_110092.1; NC_006351.1.
DR   AlphaFoldDB; Q63P77; -.
DR   STRING; 272560.BPSS0067; -.
DR   KEGG; bps:BPSS0067; -.
DR   PATRIC; fig|272560.51.peg.6083; -.
DR   eggNOG; COG3511; Bacteria.
DR   Proteomes; UP000000605; Chromosome 2.
DR   GO; GO:0034480; F:phosphatidylcholine phospholipase C activity; IEA:UniProtKB-EC.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:InterPro.
DR   CDD; cd16014; PLC; 1.
DR   Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 2.
DR   InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR   InterPro; IPR017767; Bact_PC-PLC.
DR   InterPro; IPR007312; Phosphoesterase.
DR   InterPro; IPR008475; PLipase_C_C.
DR   InterPro; IPR006311; TAT_signal.
DR   NCBIfam; TIGR03396; PC_PLC; 1.
DR   PANTHER; PTHR31956:SF8; ACID PHOSPHATASE PHOA (AFU_ORTHOLOGUE AFUA_1G03570); 1.
DR   PANTHER; PTHR31956; NON-SPECIFIC PHOSPHOLIPASE C4-RELATED; 1.
DR   Pfam; PF04185; Phosphoesterase; 1.
DR   Pfam; PF05506; PLipase_C_C; 2.
DR   PROSITE; PS51318; TAT; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000000605}.
FT   DOMAIN          529..618
FT                   /note="Bacterial phospholipase C C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05506"
FT   DOMAIN          630..712
FT                   /note="Bacterial phospholipase C C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05506"
SQ   SEQUENCE   731 AA;  80839 MW;  6E3C5A7D71141373 CRC64;
     MNARRRFLQG TATTGIAAAT LAAFPLSIRR ALAIPANNRT GTIRDVEHIV ILMQENRSFD
     NYFGTLRGVR GFGDRFGIPL PNALTVWQQR NATGALVLPY HLDGSKGNAQ RVSGTPHSWD
     DGQNAWDGGR MYQWPRYKNT ASMGYFRESE LPFQFALANA FTICDAYHCS MHAGTNSNRM
     FMWTGTNGPT GAGVASVVNE WDDIGPSTFG YEWKTYPERL QEAGVSWKVY QNMPDNFTDN
     ALAGFRQYRR ANEASGKPVS NSDKVVSPAY DPASDDVRNP LYKGIANTMP DGGFLGAFKE
     DIRAGKLPQV SWVVAPAAYS EHPGPSSPVQ GAWYIQEVLD ALTATPDVWS KTVLLVNFDE
     NDGYFDHVPS PSAPSLNPDG SPAGKTTLPE ADIAFERFTH PKPPGTKSQP QPDARVYGPG
     VRVPMYVISP WSRGGWVNSQ VFDHTSTLRF IEARFGVREP NISAFRRSVC GDLTSAFNFV
     RPNNEPLPTL AGRKTRAQAD ALRAAQQQMP QIVPPANGLL PRQETGTRPS RALPYELHVN
     AVARTLDGTL RLVFANTGQA AAVFHVYDKL NLGRLPRRYM VEAGKQLDDV WAAMTDNGGK
     YDLWVLGPNG LHRHFTGDMN RLRAGGAPVP EVRVEYDRQH GNVQLLLRNE GARECVFTVR
     AKAYRDDGPW TFKVKGGAER KHHWKLDGSG NWYDFVVTCD ADTGYSRRFA GRVETGEHSV
     SDPAMGFGDR F
//