ID Q63PB8_BURPS Unreviewed; 647 AA.
AC Q63PB8;
DT 25-OCT-2004, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2004, sequence version 1.
DT 27-MAR-2024, entry version 102.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:CAH37470.1};
GN OrderedLocusNames=BPSS0027 {ECO:0000313|EMBL:CAH37470.1};
OS Burkholderia pseudomallei (strain K96243).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia; pseudomallei group.
OX NCBI_TaxID=272560 {ECO:0000313|EMBL:CAH37470.1, ECO:0000313|Proteomes:UP000000605};
RN [1] {ECO:0000313|EMBL:CAH37470.1, ECO:0000313|Proteomes:UP000000605}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K96243 {ECO:0000313|EMBL:CAH37470.1,
RC ECO:0000313|Proteomes:UP000000605};
RX PubMed=15377794; DOI=10.1073/pnas.0403302101;
RA Holden M.T.G., Titball R.W., Peacock S.J., Cerdeno-Tarraga A.M., Atkins T.,
RA Crossman L.C., Pitt T., Churcher C., Mungall K., Bentley S.D., Sebaihia M.,
RA Thomson N.R., Bason N., Beacham I.R., Brooks K., Brown K.A., Brown N.F.,
RA Challis G.L., Cherevach I., Chillingworth T., Cronin A., Crosset B.,
RA Davis P., DeShazer D., Feltwell T., Fraser A., Hance Z., Hauser H.,
RA Holroyd S., Jagels K., Keith K.E., Maddison M., Moule S., Price C.,
RA Quail M.A., Rabbinowitsch E., Rutherford K., Sanders M., Simmonds M.,
RA Songsivilai S., Stevens K., Tumapa S., Vesaratchavest M., Whitehead S.,
RA Yeats C., Barrell B.G., Oyston P.C.F., Parkhill J.;
RT "Genomic plasticity of the causative agent of melioidosis, Burkholderia
RT pseudomallei.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:14240-14245(2004).
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; BX571966; CAH37470.1; -; Genomic_DNA.
DR RefSeq; WP_004551133.1; NZ_CP009537.1.
DR RefSeq; YP_110051.1; NC_006351.1.
DR AlphaFoldDB; Q63PB8; -.
DR STRING; 272560.BPSS0027; -.
DR KEGG; bps:BPSS0027; -.
DR PATRIC; fig|272560.51.peg.6026; -.
DR eggNOG; COG1032; Bacteria.
DR Proteomes; UP000000605; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031419; F:cobalamin binding; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR CDD; cd01335; Radical_SAM; 1.
DR Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR Gene3D; 3.80.30.20; tm_1862 like domain; 1.
DR InterPro; IPR006158; Cobalamin-bd.
DR InterPro; IPR036724; Cobalamin-bd_sf.
DR InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR InterPro; IPR034466; Methyltransferase_Class_B.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR023404; rSAM_horseshoe.
DR PANTHER; PTHR43409; ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE-RELATED; 1.
DR PANTHER; PTHR43409:SF12; BLL1977 PROTEIN; 1.
DR Pfam; PF02310; B12-binding; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDG01123; methyltransferase_(Class_B); 1.
DR SFLD; SFLDS00029; Radical_SAM; 1.
DR SMART; SM00729; Elp3; 1.
DR SUPFAM; SSF52242; Cobalamin (vitamin B12)-binding domain; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51332; B12_BINDING; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Iron {ECO:0000256|ARBA:ARBA00022485};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00022485};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022485};
KW Reference proteome {ECO:0000313|Proteomes:UP000000605}.
FT DOMAIN 10..153
FT /note="B12-binding"
FT /evidence="ECO:0000259|PROSITE:PS51332"
FT DOMAIN 193..414
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 647 AA; 71764 MW; 13882FB27E340977 CRC64;
MKLLLVDNLV MPEEGSLAYL DVHPHLGLLA LAAVAEADGH RVRIYDPKRL IRDGTLAYDA
TLYERASRAI LAERPDAVGF TALGCSFLFA LNVAALLKRR EPDLPVLLGG PHATMLHRQI
LERFPQFDII VRYEADEILP AVLDCLEQRT FDVIPGLSWR ATGHGAPLRF TDGKPKVEEL
DRLPIASYDH YPVDDLGLSM LRIEAGRGCP FACTFCSTAG FFQRSFRLKS AERLVHELDI
LHRRYRVSDF KLDHDMFTVN RHKVMAFCEA VAGRGYRWRA SARIDCVDEA LLRKMADAGC
VNLYFGVETG SERMQTICRK RLDLRLVEPI LAAADSFGIE TTASFITGYP QECGQDQDDT
LDMIGRCARR PSCLTQLHML APEPGTPLFD EHGAQIAYDG YGGPYNTRLL GPGDEREVLD
HPDIFQTYYY YPAALPRARH IFAVEAVDVL RRAGPIILAY ALREFGGRLS RLISAWRRFA
DETSPGALPD AAGLEAFVAA RFGRGHHLHS LFRYALRLSA ARAPADVVAE GPYEPDRPCM
LAENVGLLED IHNCEALVDR LRRSNDGAPA LGDADVGGLG AYIVRADGEA VTGYWVESGI
AAILDLFRAP RSCRAAAQWL AHVTRNDGVD ASIFEPLLRR GILVPAR
//
