GenomeNet

Database: UniProt
Entry: Q64507
LinkDB: Q64507
Original site: Q64507 
ID   KRA51_MOUSE             Reviewed;         230 AA.
AC   Q64507; A4IF43;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   10-APR-2019, entry version 106.
DE   RecName: Full=Keratin-associated protein 5-1 {ECO:0000250|UniProtKB:Q6L8H4};
DE   AltName: Full=Ultra high sulfur serine protein 1;
DE            Short=UHS-Ser-1;
GN   Name=Krtap5-1 {ECO:0000312|MGI:MGI:1354732};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAA40106.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RC   STRAIN=BALB/cJ {ECO:0000312|EMBL:AAA40106.1};
RX   PubMed=2250030;
RA   Wood L., Mills M., Hatzenbuhler N., Vogeli G.;
RT   "Serine-rich ultra high sulfur protein gene expression in murine hair
RT   and skin during the hair cycle.";
RL   J. Biol. Chem. 265:21375-21380(1990).
RN   [2] {ECO:0000305, ECO:0000312|EMBL:AAI04356.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments
CC       are embedded in an interfilamentous matrix, consisting of hair
CC       keratin-associated protein (KRTAP), which are essential for the
CC       formation of a rigid and resistant hair shaft through their
CC       extensive disulfide bond cross-linking with abundant cysteine
CC       residues of hair keratins. The matrix proteins include the high-
CC       sulfur and high-glycine-tyrosine keratins. {ECO:0000305}.
CC   -!- SUBUNIT: Interacts with hair keratins. {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1 {ECO:0000269|PubMed:2250030};
CC         IsoId=Q64507-1; Sequence=Displayed;
CC       Name=2 {ECO:0000269|PubMed:15489334};
CC         IsoId=Q64507-2; Sequence=VSP_052994;
CC         Note=No experimental confirmation available. {ECO:0000305};
CC   -!- TISSUE SPECIFICITY: Expressed during the active phases of the hair
CC       cycle in the medulla and the inner root sheath of the forming
CC       hair. Also expressed in the upper layers of the epidermis of skin.
CC       {ECO:0000269|PubMed:2250030}.
CC   -!- SIMILARITY: Belongs to the KRTAP type 5 family.
CC       {ECO:0000250|UniProtKB:Q6L8H4}.
DR   EMBL; M37759; AAA40106.1; -; Genomic_DNA.
DR   EMBL; BC104355; AAI04356.1; -; mRNA.
DR   CCDS; CCDS80834.1; -. [Q64507-1]
DR   PIR; A38346; A38346.
DR   RefSeq; NP_056623.1; NM_015808.1. [Q64507-1]
DR   UniGene; Mm.389993; -.
DR   ProteinModelPortal; Q64507; -.
DR   DIP; DIP-112N; -.
DR   STRING; 10090.ENSMUSP00000139752; -.
DR   PhosphoSitePlus; Q64507; -.
DR   PRIDE; Q64507; -.
DR   Ensembl; ENSMUST00000188274; ENSMUSP00000139752; ENSMUSG00000066100. [Q64507-1]
DR   GeneID; 50774; -.
DR   KEGG; mmu:50774; -.
DR   UCSC; uc009kmr.1; mouse. [Q64507-1]
DR   CTD; 387264; -.
DR   MGI; MGI:1354732; Krtap5-1.
DR   GeneTree; ENSGT00940000164129; -.
DR   OMA; KGVCGFR; -.
DR   PRO; PR:Q64507; -.
DR   Proteomes; UP000000589; Chromosome 7.
DR   Bgee; ENSMUSG00000066100; Expressed in 8 organ(s), highest expression level in zone of skin.
DR   ExpressionAtlas; Q64507; baseline and differential.
DR   Genevisible; Q64507; MM.
DR   GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR   InterPro; IPR002494; KAP.
DR   PANTHER; PTHR23262; PTHR23262; 3.
DR   Pfam; PF13885; Keratin_B2_2; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Complete proteome; Keratin; Reference proteome;
KW   Repeat.
FT   CHAIN         1    230       Keratin-associated protein 5-1.
FT                                /FTId=PRO_0000361657.
FT   REPEAT       42     45       1. {ECO:0000255}.
FT   REPEAT       48     51       2. {ECO:0000255}.
FT   REPEAT       54     57       3. {ECO:0000255}.
FT   REPEAT       88     91       4. {ECO:0000255}.
FT   REPEAT       94     97       5. {ECO:0000255}.
FT   REPEAT      116    119       6. {ECO:0000255}.
FT   REPEAT      134    137       7. {ECO:0000255}.
FT   REPEAT      144    147       8. {ECO:0000255}.
FT   REPEAT      154    157       9. {ECO:0000255}.
FT   REPEAT      172    175       10. {ECO:0000255}.
FT   REPEAT      182    185       11. {ECO:0000255}.
FT   REPEAT      192    195       12. {ECO:0000255}.
FT   REPEAT      202    205       13. {ECO:0000255}.
FT   REPEAT      212    215       14. {ECO:0000255}.
FT   REGION       42    215       14 X 4 AA repeats of C-C-X-P.
FT                                {ECO:0000255}.
FT   VAR_SEQ     150    217       Missing (in isoform 2).
FT                                {ECO:0000303|PubMed:15489334}.
FT                                /FTId=VSP_052994.
FT   CONFLICT    132    132       S -> D (in Ref. 2; AAI04356).
FT                                {ECO:0000305}.
SQ   SEQUENCE   230 AA;  21782 MW;  6CC50B41B2137C23 CRC64;
     MTCCGCSGGC GSSCGGCGSS CGGCGSGCGG CGSNCGGCGS SCCKPVCCCK PVCCCVPVCS
     CSSCGGCGSS CGGCGSCGSS CGGCGSSCCK PVCCCVPVCS CSSCGGCKPC CCQSSCCKPC
     CSSGCGSSCC QSSCCKPCCC QSSCCKPCCC QSSCCKPCCS SGCGSSCCQS SCCKPCCCQS
     SCCKPCCCQS SCCKPCCCQS SCCKPCCCQS SCCKPCCSSG CGSSCCQDSC
//
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