ID Q65F60_BACLD Unreviewed; 594 AA.
AC Q65F60; Q62QM5;
DT 25-OCT-2004, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2004, sequence version 1.
DT 27-MAR-2024, entry version 119.
DE SubName: Full=Peptidase M, neutral zinc metallopeptidases {ECO:0000313|EMBL:AAU24935.1};
GN Name=yusX {ECO:0000313|EMBL:AAU24935.1};
GN OrderedLocusNames=BL02187 {ECO:0000313|EMBL:AAU24935.1};
OS Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 /
OS NBRC 12200 / NCIMB 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46).
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=279010 {ECO:0000313|EMBL:AAU24935.1, ECO:0000313|Proteomes:UP000000606};
RN [1] {ECO:0000313|EMBL:AAU24935.1, ECO:0000313|Proteomes:UP000000606}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB
RC 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46
RC {ECO:0000313|Proteomes:UP000000606};
RX PubMed=15461803; DOI=10.1186/gb-2004-5-10-r77;
RA Rey M.W., Ramaiya P., Nelson B.A., Brody-Karpin S.D., Zaretsky E.J.,
RA Tang M., Lopez de Leon A., Xiang H., Gusti V., Clausen I.G., Olsen P.B.,
RA Rasmussen M.D., Andersen J.T., Jorgensen P.L., Larsen T.S., Sorokin A.,
RA Bolotin A., Lapidus A., Galleron N., Ehrlich S.D., Berka R.M.;
RT "Complete genome sequence of the industrial bacterium Bacillus
RT licheniformis and comparisons with closely related Bacillus species.";
RL Genome Biol. 5:R77.1-R77.12(2004).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU003435};
CC Note=Binds 1 zinc ion. {ECO:0000256|RuleBase:RU003435};
CC -!- SIMILARITY: Belongs to the peptidase M3 family.
CC {ECO:0000256|RuleBase:RU003435}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000002; AAU24935.1; -; Genomic_DNA.
DR RefSeq; WP_003185092.1; NC_006322.1.
DR AlphaFoldDB; Q65F60; -.
DR STRING; 279010.BL02187; -.
DR MEROPS; M03.A08; -.
DR KEGG; bli:BL02187; -.
DR PATRIC; fig|279010.13.peg.3529; -.
DR eggNOG; COG1164; Bacteria.
DR HOGENOM; CLU_021290_3_1_9; -.
DR Proteomes; UP000000606; Chromosome.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004181; F:metallocarboxypeptidase activity; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd09607; M3B_PepF; 1.
DR Gene3D; 1.10.1370.20; Oligoendopeptidase f, C-terminal domain; 1.
DR Gene3D; 1.20.140.70; Oligopeptidase f, N-terminal domain; 1.
DR InterPro; IPR034006; M3B_PepF_2.
DR InterPro; IPR013647; OligopepF_N_dom.
DR InterPro; IPR042088; OligoPept_F_C.
DR InterPro; IPR001567; Pept_M3A_M3B_dom.
DR InterPro; IPR011977; Pept_M3B_clade3.
DR InterPro; IPR001333; Peptidase_M32_Taq.
DR NCBIfam; TIGR02290; M3_fam_3; 1.
DR PANTHER; PTHR34217:SF1; CARBOXYPEPTIDASE 1; 1.
DR PANTHER; PTHR34217; METAL-DEPENDENT CARBOXYPEPTIDASE; 1.
DR Pfam; PF01432; Peptidase_M3; 1.
DR Pfam; PF08439; Peptidase_M3_N; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|RuleBase:RU003435};
KW Metal-binding {ECO:0000256|RuleBase:RU003435};
KW Metalloprotease {ECO:0000256|RuleBase:RU003435};
KW Protease {ECO:0000256|RuleBase:RU003435};
KW Reference proteome {ECO:0000313|Proteomes:UP000000606};
KW Zinc {ECO:0000256|RuleBase:RU003435}.
FT DOMAIN 120..177
FT /note="Oligopeptidase F N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08439"
FT DOMAIN 201..580
FT /note="Peptidase M3A/M3B catalytic"
FT /evidence="ECO:0000259|Pfam:PF01432"
SQ SEQUENCE 594 AA; 67026 MW; F12E611FD1BDA174 CRC64;
MTFHQLKDTW DLEVFFKGGS GSAEFRQYLN EIKTLLSTFK RSAEALTVSK SGLDELKETL
ALFETIDVKI READAFVGCL QAQDTADLKA NALNFEVTRL AADAQKALVV LDSKFAVVPN
VEWEAILQDE SISDIAYILN ERRERVTEKL SSEQETLIQG LSVDGYHAWG DMYDSIVDQI
QIPYEEDGET KILSVGQAQN LTSKPDRKIR RSVSENLDHG WEQHADLLSS TLNHLAGFRL
NVYEARGWDN VLKEPLDINR MKQETLDVMW QVIIDHKKPF ADYLSRKASL LGLDKLSWYD
VEAPIGSAAK EYSYQEAAAF ITGQFKTFGK KLSSFAEKAL RDRWVEAEDR GGKRPGGFCA
NFPDSGESRI FMTFAGSQSN VSTLAHELGH AFHQESMLDV RPLNRAYAMN VAETASTFAE
MIVADAALKQ AGSDEEKIVL LEDKVQRSVA FFMNIHARFL FETRFYDERK NGVVSAGRLN
ELMEEAQKEA FCGALGEYHP YFWASKLHFY ITSVPFYNFP YTFGYLFSLG IYAQALKEGA
AFEEKYIALL KDTASMSVEE LAMKHLGADL TKRDFWEAAI QPAVRDAEAF LAMT
//
