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Database: UniProt
Entry: Q65F71_BACLD
LinkDB: Q65F71_BACLD
Original site: Q65F71_BACLD 
ID   Q65F71_BACLD            Unreviewed;       796 AA.
AC   Q65F71; Q62QN6;
DT   25-OCT-2004, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2004, sequence version 1.
DT   24-JAN-2024, entry version 137.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase YusL {ECO:0000313|EMBL:AAU24924.1};
GN   Name=yusL {ECO:0000313|EMBL:AAU24924.1};
GN   OrderedLocusNames=BL02180 {ECO:0000313|EMBL:AAU24924.1};
OS   Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 /
OS   NBRC 12200 / NCIMB 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46).
OC   Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=279010 {ECO:0000313|EMBL:AAU24924.1, ECO:0000313|Proteomes:UP000000606};
RN   [1] {ECO:0000313|EMBL:AAU24924.1, ECO:0000313|Proteomes:UP000000606}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB
RC   9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46
RC   {ECO:0000313|Proteomes:UP000000606};
RX   PubMed=15461803; DOI=10.1186/gb-2004-5-10-r77;
RA   Rey M.W., Ramaiya P., Nelson B.A., Brody-Karpin S.D., Zaretsky E.J.,
RA   Tang M., Lopez de Leon A., Xiang H., Gusti V., Clausen I.G., Olsen P.B.,
RA   Rasmussen M.D., Andersen J.T., Jorgensen P.L., Larsen T.S., Sorokin A.,
RA   Bolotin A., Lapidus A., Galleron N., Ehrlich S.D., Berka R.M.;
RT   "Complete genome sequence of the industrial bacterium Bacillus
RT   licheniformis and comparisons with closely related Bacillus species.";
RL   Genome Biol. 5:R77.1-R77.12(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC         NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|ARBA:ARBA00023693};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|ARBA:ARBA00005005}.
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DR   EMBL; CP000002; AAU24924.1; -; Genomic_DNA.
DR   RefSeq; WP_011198274.1; NC_006322.1.
DR   AlphaFoldDB; Q65F71; -.
DR   STRING; 279010.BL02180; -.
DR   KEGG; bli:BL02180; -.
DR   PATRIC; fig|279010.13.peg.3518; -.
DR   eggNOG; COG1024; Bacteria.
DR   eggNOG; COG1250; Bacteria.
DR   HOGENOM; CLU_010448_0_0_9; -.
DR   OMA; GQGFYKK; -.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000000606; Chromosome.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   CDD; cd06558; crotonase-like; 1.
DR   Gene3D; 1.10.1040.50; -; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR   SUPFAM; SSF52096; ClpP/crotonase; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000606}.
FT   DOMAIN          7..205
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          208..306
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
SQ   SEQUENCE   796 AA;  87674 MW;  0F7725900BA0EEDC CRC64;
     MVKHIRKAAV IGSGVMGSGI AAHLANIGIP VLLLDMVPHE LTDEERKKGR TLEDPDVRNR
     LARTAVQKLL KQKPAPLTSK KNISRISTGN MEDDFEKIKD ADWIIEVVVE NLEIKKQVFS
     KVDQYRKQGS IVSSNTSGIS VRQMAEGRSA DFKKHFLGTH FFNPARYLKL LEVIPIDETE
     PEVLSFMKKF GEDVLGKGVV EAKDTPNFIA NRIGTYGLLV TVQEMLKGGY TIGEVDSITG
     PLIGRPKSAT FRTLDVVGLD TFSHVAKNVY NQVTGEEKNV FRLPEFIEQM LEKGWIGSKA
     KQGFYKKEGK DILELDPMTM TYSARQTLKT SGLEAAKQMK GAGARLKALV YSDDRAGSLL
     WKITAPTLVY SAELTGEIAD SITAVDQAMK WGFGWSEGPF EMWDSIGVKS SVQKLEAEGW
     KVADWVKEML AKGHETFYLK ENGKTFYYCF ESGEYRALQE NKKTIHLSSL KETKGVIKKN
     SGASLIDLGD DVALLEFHSK SNAIGLDIIQ MLKFALEEVD ANYKGLVIGN QGKNFCVGAN
     LAMMLMEAQD DNYMEIDMII RQFQETMMKV KYSSKPVVAA PFGMTLGGGT ELCLPAARVQ
     ASSESYMGLV ETGVGLIPGG GGNKELYLNY LKGLPEGVKP DIQEAAIKTF ETIALAKTST
     SAQEAKELNI LTAEDQISIN QDHLLYDAKK LVLTLSESGY RPPVKEKVPV TGETGYAALL
     LGAESLKLSG AISEHDMKIA KKLAFVIAGG RVPFGAEVTE EYLLNLEREA FLSLVSEPKS
     QARMQHMLVK GKPLRN
//
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