ID Q65F71_BACLD Unreviewed; 796 AA.
AC Q65F71; Q62QN6;
DT 25-OCT-2004, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2004, sequence version 1.
DT 24-JAN-2024, entry version 137.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase YusL {ECO:0000313|EMBL:AAU24924.1};
GN Name=yusL {ECO:0000313|EMBL:AAU24924.1};
GN OrderedLocusNames=BL02180 {ECO:0000313|EMBL:AAU24924.1};
OS Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 /
OS NBRC 12200 / NCIMB 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46).
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=279010 {ECO:0000313|EMBL:AAU24924.1, ECO:0000313|Proteomes:UP000000606};
RN [1] {ECO:0000313|EMBL:AAU24924.1, ECO:0000313|Proteomes:UP000000606}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB
RC 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46
RC {ECO:0000313|Proteomes:UP000000606};
RX PubMed=15461803; DOI=10.1186/gb-2004-5-10-r77;
RA Rey M.W., Ramaiya P., Nelson B.A., Brody-Karpin S.D., Zaretsky E.J.,
RA Tang M., Lopez de Leon A., Xiang H., Gusti V., Clausen I.G., Olsen P.B.,
RA Rasmussen M.D., Andersen J.T., Jorgensen P.L., Larsen T.S., Sorokin A.,
RA Bolotin A., Lapidus A., Galleron N., Ehrlich S.D., Berka R.M.;
RT "Complete genome sequence of the industrial bacterium Bacillus
RT licheniformis and comparisons with closely related Bacillus species.";
RL Genome Biol. 5:R77.1-R77.12(2004).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
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DR EMBL; CP000002; AAU24924.1; -; Genomic_DNA.
DR RefSeq; WP_011198274.1; NC_006322.1.
DR AlphaFoldDB; Q65F71; -.
DR STRING; 279010.BL02180; -.
DR KEGG; bli:BL02180; -.
DR PATRIC; fig|279010.13.peg.3518; -.
DR eggNOG; COG1024; Bacteria.
DR eggNOG; COG1250; Bacteria.
DR HOGENOM; CLU_010448_0_0_9; -.
DR OMA; GQGFYKK; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000000606; Chromosome.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000000606}.
FT DOMAIN 7..205
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 208..306
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 796 AA; 87674 MW; 0F7725900BA0EEDC CRC64;
MVKHIRKAAV IGSGVMGSGI AAHLANIGIP VLLLDMVPHE LTDEERKKGR TLEDPDVRNR
LARTAVQKLL KQKPAPLTSK KNISRISTGN MEDDFEKIKD ADWIIEVVVE NLEIKKQVFS
KVDQYRKQGS IVSSNTSGIS VRQMAEGRSA DFKKHFLGTH FFNPARYLKL LEVIPIDETE
PEVLSFMKKF GEDVLGKGVV EAKDTPNFIA NRIGTYGLLV TVQEMLKGGY TIGEVDSITG
PLIGRPKSAT FRTLDVVGLD TFSHVAKNVY NQVTGEEKNV FRLPEFIEQM LEKGWIGSKA
KQGFYKKEGK DILELDPMTM TYSARQTLKT SGLEAAKQMK GAGARLKALV YSDDRAGSLL
WKITAPTLVY SAELTGEIAD SITAVDQAMK WGFGWSEGPF EMWDSIGVKS SVQKLEAEGW
KVADWVKEML AKGHETFYLK ENGKTFYYCF ESGEYRALQE NKKTIHLSSL KETKGVIKKN
SGASLIDLGD DVALLEFHSK SNAIGLDIIQ MLKFALEEVD ANYKGLVIGN QGKNFCVGAN
LAMMLMEAQD DNYMEIDMII RQFQETMMKV KYSSKPVVAA PFGMTLGGGT ELCLPAARVQ
ASSESYMGLV ETGVGLIPGG GGNKELYLNY LKGLPEGVKP DIQEAAIKTF ETIALAKTST
SAQEAKELNI LTAEDQISIN QDHLLYDAKK LVLTLSESGY RPPVKEKVPV TGETGYAALL
LGAESLKLSG AISEHDMKIA KKLAFVIAGG RVPFGAEVTE EYLLNLEREA FLSLVSEPKS
QARMQHMLVK GKPLRN
//