ID Q65H69_BACLD Unreviewed; 716 AA.
AC Q65H69; Q62SM6;
DT 25-OCT-2004, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2004, sequence version 1.
DT 27-MAR-2024, entry version 112.
DE SubName: Full=HDIG-domain containing protein {ECO:0000313|EMBL:AAU24233.1};
GN OrderedLocusNames=BL03670 {ECO:0000313|EMBL:AAU24233.1};
OS Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 /
OS NBRC 12200 / NCIMB 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46).
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=279010 {ECO:0000313|EMBL:AAU24233.1, ECO:0000313|Proteomes:UP000000606};
RN [1] {ECO:0000313|EMBL:AAU24233.1, ECO:0000313|Proteomes:UP000000606}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB
RC 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46
RC {ECO:0000313|Proteomes:UP000000606};
RX PubMed=15461803; DOI=10.1186/gb-2004-5-10-r77;
RA Rey M.W., Ramaiya P., Nelson B.A., Brody-Karpin S.D., Zaretsky E.J.,
RA Tang M., Lopez de Leon A., Xiang H., Gusti V., Clausen I.G., Olsen P.B.,
RA Rasmussen M.D., Andersen J.T., Jorgensen P.L., Larsen T.S., Sorokin A.,
RA Bolotin A., Lapidus A., Galleron N., Ehrlich S.D., Berka R.M.;
RT "Complete genome sequence of the industrial bacterium Bacillus
RT licheniformis and comparisons with closely related Bacillus species.";
RL Genome Biol. 5:R77.1-R77.12(2004).
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DR EMBL; CP000002; AAU24233.1; -; Genomic_DNA.
DR AlphaFoldDB; Q65H69; -.
DR STRING; 279010.BL03670; -.
DR KEGG; bli:BL03670; -.
DR PATRIC; fig|279010.13.peg.2768; -.
DR eggNOG; COG1480; Bacteria.
DR HOGENOM; CLU_015767_1_2_9; -.
DR Proteomes; UP000000606; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00077; HDc; 1.
DR CDD; cd12082; MATE_like; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR006675; HDIG_dom.
DR InterPro; IPR011624; Metal-dep_PHydrolase_7TM_extra.
DR InterPro; IPR011621; Metal-dep_PHydrolase_7TM_intra.
DR NCBIfam; TIGR00277; HDIG; 1.
DR PANTHER; PTHR36442; CYCLIC-DI-AMP PHOSPHODIESTERASE PGPH; 1.
DR PANTHER; PTHR36442:SF1; CYCLIC-DI-AMP PHOSPHODIESTERASE PGPH; 1.
DR Pfam; PF07698; 7TM-7TMR_HD; 1.
DR Pfam; PF07697; 7TMR-HDED; 1.
DR Pfam; PF01966; HD; 1.
DR SMART; SM00471; HDc; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR PROSITE; PS51831; HD; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000606};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 280..299
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 311..333
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 339..357
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 387..404
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 416..435
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 447..469
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 502..644
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
FT REGION 114..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 114..138
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 716 AA; 79842 MW; BB407D43FABAD4CD CRC64;
MKKKKRGGKF RLIRLNNGGF LPVILYAALS ALMFILLFFH VRPESLDLDL FSISENTIYA
PATVEDQKAT ANKKQEAREE VPDQYTLKKE YSDNRVDLVS SIFDIIKEVK KESAEKEKKD
KQAPSEKDQI KSVEEKLTSD VTDSLSQDSV KHLLRASDGE LSMTQDSVIT AVNDVMSKEI
RAGKLDEAKE HVTKELKGNS IPSKLKNAAD EIGRFAIIPN YVYDPDKTEQ KRQEAADSVQ
QVQIKQGQIL VEENQLIDRE VYRKLELTGL LSGANIFKPV GGLLLLIALF ISALVYYFEK
QYSSRIPKNK SLMLFSLITG IVLIVMEVIS LFQQLEIGHI GYLVPIAMGV MLIKLLINER
LAILSSMILS ICGSMMFNQG VTGTFNYGIG TYFLISSMAG ILFLGKHNAR AKILQAGLFV
SLINIVVLFT LQLIQNTAQT GLEMGTYLVM GAVSGIGSSV LVLGLMPFFE SGFGILSTMK
LLELSNPNHP LLRKILTETP GTYHHSVMVA NLSEAACEAV GANGLLARVG AYYHDIGKTK
RPQYFIENQM NIDNPHDKLS PQLSKNIIIA HVTDGADMLR DHKMPKELVD IAEQHHGTSL
LKFFYYKAKE KGDQTTEEEF RYPGPKPQTK EAAIISVADS VEAAVRSMHN PNPERIEKLV
RGIIADKLQD GQFDECDLTL KELNTIAKTL CETLKGIFHS RIEYPEANPK QKVKHT
//
