ID Q65IV3_BACLD Unreviewed; 431 AA.
AC Q65IV3; Q62UB1;
DT 25-OCT-2004, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2004, sequence version 1.
DT 27-MAR-2024, entry version 97.
DE RecName: Full=Arsenical pump membrane protein {ECO:0000256|RuleBase:RU004993};
GN Name=ydfA {ECO:0000313|EMBL:AAU23648.1};
GN OrderedLocusNames=BL01870 {ECO:0000313|EMBL:AAU23648.1};
OS Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 /
OS NBRC 12200 / NCIMB 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46).
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=279010 {ECO:0000313|EMBL:AAU23648.1, ECO:0000313|Proteomes:UP000000606};
RN [1] {ECO:0000313|EMBL:AAU23648.1, ECO:0000313|Proteomes:UP000000606}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB
RC 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46
RC {ECO:0000313|Proteomes:UP000000606};
RX PubMed=15461803; DOI=10.1186/gb-2004-5-10-r77;
RA Rey M.W., Ramaiya P., Nelson B.A., Brody-Karpin S.D., Zaretsky E.J.,
RA Tang M., Lopez de Leon A., Xiang H., Gusti V., Clausen I.G., Olsen P.B.,
RA Rasmussen M.D., Andersen J.T., Jorgensen P.L., Larsen T.S., Sorokin A.,
RA Bolotin A., Lapidus A., Galleron N., Ehrlich S.D., Berka R.M.;
RT "Complete genome sequence of the industrial bacterium Bacillus
RT licheniformis and comparisons with closely related Bacillus species.";
RL Genome Biol. 5:R77.1-R77.12(2004).
CC -!- FUNCTION: Involved in arsenical resistance. Thought to form the channel
CC of an arsenite pump. {ECO:0000256|RuleBase:RU004993}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU004993};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU004993}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ArsB family. {ECO:0000256|ARBA:ARBA00006433,
CC ECO:0000256|RuleBase:RU004993}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU004993}.
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DR EMBL; CP000002; AAU23648.1; -; Genomic_DNA.
DR RefSeq; WP_003182413.1; NC_006322.1.
DR AlphaFoldDB; Q65IV3; -.
DR STRING; 279010.BL01870; -.
DR GeneID; 66215874; -.
DR KEGG; bli:BL01870; -.
DR PATRIC; fig|279010.13.peg.2131; -.
DR eggNOG; COG1055; Bacteria.
DR HOGENOM; CLU_043931_1_0_9; -.
DR Proteomes; UP000000606; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015105; F:arsenite transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0046685; P:response to arsenic-containing substance; IEA:UniProtKB-KW.
DR CDD; cd01118; ArsB_permease; 1.
DR InterPro; IPR000802; Arsenical_pump_ArsB.
DR NCBIfam; TIGR00935; 2a45; 1.
DR PANTHER; PTHR43302; TRANSPORTER ARSB-RELATED; 1.
DR PANTHER; PTHR43302:SF5; TRANSPORTER ARSB-RELATED; 1.
DR Pfam; PF02040; ArsB; 1.
DR PRINTS; PR00758; ARSENICPUMP.
PE 3: Inferred from homology;
KW Arsenical resistance {ECO:0000256|ARBA:ARBA00022849,
KW ECO:0000256|RuleBase:RU004993};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU004993};
KW Reference proteome {ECO:0000313|Proteomes:UP000000606};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU004993};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU004993}; Transport {ECO:0000256|RuleBase:RU004993}.
FT TRANSMEM 53..72
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004993"
FT TRANSMEM 93..110
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004993"
FT TRANSMEM 116..132
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004993"
FT TRANSMEM 139..162
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004993"
FT TRANSMEM 182..200
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004993"
FT TRANSMEM 225..242
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004993"
FT TRANSMEM 248..265
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004993"
FT TRANSMEM 277..298
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004993"
FT TRANSMEM 318..336
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004993"
FT TRANSMEM 408..429
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004993"
SQ SEQUENCE 431 AA; 46723 MW; 38DEF5AEFD09086F CRC64;
MTTVLATLIF LLTLTLVIWQ PKNLSIGWSA CGGAVLALIA GVVNFQDVLD VTGIVWNATL
AFVAIIIISL ILDEIGFFEW AALHMAKAAK GNGIRMFVYV TLLGAVVAAL FANDGAALIL
TPIVLAMVRA LNFQEKLVFP FIIASGFIAD TTSLPLVVSN LVNIVSADFF NIGFIEYATR
MIVPNLFSLI ASIIVLFLFF RKSIPRHYDM TNVKQPAEAI RDRKIFRLSW LILAVLLAGY
FISELFSIPV SIIAGVIAVI FLITAKNSPA VQTKKVLKGA PWAIVFFSIG MYVVVYGLRN
AGLTDVLSQV IQTVSDQGLF AGTMGMGFIA AILSSLMNNM PTVMIDALAI QNTDTHGILR
EALIYANVIG SDLGPKITPI GSLATLLWLH VLSLKGVKIS WGTYFKTGVI LTIPTLFITL
AGLYVWLLII H
//
