GenomeNet

Database: UniProt
Entry: Q65T79_MANSM
LinkDB: Q65T79_MANSM
Original site: Q65T79_MANSM 
ID   Q65T79_MANSM            Unreviewed;       510 AA.
AC   Q65T79;
DT   25-OCT-2004, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2004, sequence version 1.
DT   20-JUN-2018, entry version 81.
DE   RecName: Full=NAD(P) transhydrogenase subunit alpha {ECO:0000256|PIRNR:PIRNR000203};
DE            EC=1.6.1.2 {ECO:0000256|PIRNR:PIRNR000203};
GN   Name=pntA {ECO:0000313|EMBL:AAU37831.1};
GN   OrderedLocusNames=MS1224 {ECO:0000313|EMBL:AAU37831.1};
OS   Mannheimia succiniciproducens (strain MBEL55E).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Basfia.
OX   NCBI_TaxID=221988 {ECO:0000313|EMBL:AAU37831.1, ECO:0000313|Proteomes:UP000000607};
RN   [1] {ECO:0000313|EMBL:AAU37831.1, ECO:0000313|Proteomes:UP000000607}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MBEL55E {ECO:0000313|EMBL:AAU37831.1,
RC   ECO:0000313|Proteomes:UP000000607};
RX   PubMed=15378067; DOI=10.1038/nbt1010;
RA   Hong S.H., Kim J.S., Lee S.Y., In Y.H., Choi S.S., Rih J.-K.,
RA   Kim C.H., Jeong H., Hur C.G., Kim J.J.;
RT   "The genome sequence of the capnophilic rumen bacterium Mannheimia
RT   succiniciproducens.";
RL   Nat. Biotechnol. 22:1275-1281(2004).
CC   -!- FUNCTION: The transhydrogenation between NADH and NADP is coupled
CC       to respiration and ATP hydrolysis and functions as a proton pump
CC       across the membrane. {ECO:0000256|PIRNR:PIRNR000203}.
CC   -!- CATALYTIC ACTIVITY: NADPH + NAD(+) = NADP(+) + NADH.
CC       {ECO:0000256|PIRNR:PIRNR000203}.
CC   -!- SIMILARITY: Belongs to the AlaDH/PNT family.
CC       {ECO:0000256|PIRNR:PIRNR000203}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AE016827; AAU37831.1; -; Genomic_DNA.
DR   RefSeq; WP_011200398.1; NC_006300.1.
DR   ProteinModelPortal; Q65T79; -.
DR   STRING; 221988.MS1224; -.
DR   EnsemblBacteria; AAU37831; AAU37831; MS1224.
DR   KEGG; msu:MS1224; -.
DR   eggNOG; ENOG4108IIE; Bacteria.
DR   eggNOG; COG3288; LUCA.
DR   HOGENOM; HOG000022121; -.
DR   KO; K00324; -.
DR   OMA; AKVFIMG; -.
DR   OrthoDB; POG091H0397; -.
DR   BioCyc; MSUC221988:MS_RS05610-MONOMER; -.
DR   Proteomes; UP000000607; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008750; F:NAD(P)+ transhydrogenase (AB-specific) activity; IEA:UniProtKB-EC.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR   InterPro; IPR008143; Ala_DH/PNT_CS2.
DR   InterPro; IPR008142; AlaDH/PNT_CS1.
DR   InterPro; IPR007886; AlaDH/PNT_N.
DR   InterPro; IPR007698; AlaDH/PNT_NAD(H)-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR026255; NADP_transhyd_a.
DR   InterPro; IPR024605; NADP_transhyd_a_C.
DR   Pfam; PF01262; AlaDh_PNT_C; 1.
DR   Pfam; PF05222; AlaDh_PNT_N; 1.
DR   Pfam; PF12769; PNTB_4TM; 1.
DR   PIRSF; PIRSF000203; NADP_transhydrogenase_alpha; 1.
DR   SMART; SM01002; AlaDh_PNT_C; 1.
DR   SMART; SM01003; AlaDh_PNT_N; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR00561; pntA; 1.
DR   PROSITE; PS00836; ALADH_PNT_1; 1.
DR   PROSITE; PS00837; ALADH_PNT_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000607};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   NAD {ECO:0000256|PIRNR:PIRNR000203};
KW   NADP {ECO:0000256|PIRNR:PIRNR000203};
KW   Nucleotide-binding {ECO:0000256|PIRNR:PIRNR000203};
KW   Oxidoreductase {ECO:0000256|PIRNR:PIRNR000203};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000607};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    168    191       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    400    417       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    423    442       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    454    472       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    478    499       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        4    137       AlaDh_PNT_N. {ECO:0000259|SMART:SM01003}.
FT   DOMAIN      146    311       AlaDh_PNT_C. {ECO:0000259|SMART:SM01002}.
SQ   SEQUENCE   510 AA;  54747 MW;  FC346832B5078612 CRC64;
     MLIGVPRELL DNESRVAATP KTVQQILKLG FDVIIEHDAG FKASFEDNAF EQAGAKIGDQ
     QAVWNADVIF KVNPPTDDEI ALMKEGSTLV SFIWPAQRPD LMEKLSTKNV NVLAMDAVPR
     ISRAQALDAL SSMANISGYR AVIEAANAFG SFFTGQITAA GKVPPAKVLV IGAGVAGLAA
     IGAANSLGAI VRAFDSRPEV KEQVQSMGAS FLEIDFKEEG GSGDGYAKVM SEEFNRRAME
     LYAEQAKDVD IIITTAAIPG KPAPRLITKE MVDSMKPGSV IVDLAALTGG NCEYTKAGEI
     FVTDNQVKVI GYTDFPSRLP TQSSQLYGTN LVNLLKLLAP NKDGQIDLNF EDVVIRGVTV
     IRNGEVTWPA PPIKVSAQPQ QKAAAQKVEK KEEKPKDPRI KYGVMALAAI LFLWLASVAP
     SAFLSHFTVF VLACVVGYYV VWNVSHALHT PLMAVTNAIS GIIIVGAVLQ IAQGSFFISV
     LAFIAILVAS INIFGGFKVT QRMLAMFRKG
//
DBGET integrated database retrieval system