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Database: UniProt
Entry: Q65TJ9_MANSM
LinkDB: Q65TJ9_MANSM
Original site: Q65TJ9_MANSM 
ID   Q65TJ9_MANSM            Unreviewed;       351 AA.
AC   Q65TJ9;
DT   25-OCT-2004, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2004, sequence version 1.
DT   08-MAY-2019, entry version 89.
DE   RecName: Full=Phospho-2-dehydro-3-deoxyheptonate aldolase {ECO:0000256|PIRNR:PIRNR001361};
DE            EC=2.5.1.54 {ECO:0000256|PIRNR:PIRNR001361};
GN   Name=aroG {ECO:0000313|EMBL:AAU37711.1};
GN   OrderedLocusNames=MS1104 {ECO:0000313|EMBL:AAU37711.1};
OS   Mannheimia succiniciproducens (strain MBEL55E).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Basfia.
OX   NCBI_TaxID=221988 {ECO:0000313|EMBL:AAU37711.1, ECO:0000313|Proteomes:UP000000607};
RN   [1] {ECO:0000313|EMBL:AAU37711.1, ECO:0000313|Proteomes:UP000000607}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MBEL55E {ECO:0000313|EMBL:AAU37711.1,
RC   ECO:0000313|Proteomes:UP000000607};
RX   PubMed=15378067; DOI=10.1038/nbt1010;
RA   Hong S.H., Kim J.S., Lee S.Y., In Y.H., Choi S.S., Rih J.-K.,
RA   Kim C.H., Jeong H., Hur C.G., Kim J.J.;
RT   "The genome sequence of the capnophilic rumen bacterium Mannheimia
RT   succiniciproducens.";
RL   Nat. Biotechnol. 22:1275-1281(2004).
CC   -!- FUNCTION: Stereospecific condensation of phosphoenolpyruvate (PEP)
CC       and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-
CC       arabino-heptulosonate-7-phosphate (DAHP).
CC       {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702;
CC         EC=2.5.1.54; Evidence={ECO:0000256|PIRNR:PIRNR001361};
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and
CC       phosphoenolpyruvate: step 1/7. {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- SIMILARITY: Belongs to the class-I DAHP synthase family.
CC       {ECO:0000256|PIRNR:PIRNR001361}.
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DR   EMBL; AE016827; AAU37711.1; -; Genomic_DNA.
DR   RefSeq; WP_011200279.1; NC_006300.1.
DR   STRING; 221988.MS1104; -.
DR   EnsemblBacteria; AAU37711; AAU37711; MS1104.
DR   KEGG; msu:MS1104; -.
DR   eggNOG; ENOG4105E99; Bacteria.
DR   eggNOG; COG0722; LUCA.
DR   HOGENOM; HOG000220501; -.
DR   KO; K01626; -.
DR   OMA; VMENVAN; -.
DR   OrthoDB; 853329at2; -.
DR   BioCyc; MSUC221988:MS_RS05095-MONOMER; -.
DR   UniPathway; UPA00053; UER00084.
DR   Proteomes; UP000000607; Chromosome.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006218; DAHP1/KDSA.
DR   InterPro; IPR006219; DHAP_synth_1.
DR   PANTHER; PTHR21225; PTHR21225; 1.
DR   Pfam; PF00793; DAHP_synth_1; 1.
DR   PIRSF; PIRSF001361; DAHP_synthase; 1.
DR   TIGRFAMs; TIGR00034; aroFGH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Aromatic amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000607};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000607};
KW   Transferase {ECO:0000256|PIRNR:PIRNR001361,
KW   ECO:0000256|SAAS:SAAS00080156}.
FT   DOMAIN       40    339       DAHP_synth_1. {ECO:0000259|Pfam:PF00793}.
SQ   SEQUENCE   351 AA;  38643 MW;  BEC8E6B04D453E66 CRC64;
     MKDSIHNVHI IDEKVLITPA ELKQKLPLPI ALRTQIETHR REIADIVHKK DDRLLVVIGP
     CSVHDTKAAI DYAKRLKALS DELKDQLYIV MRVYFEKPRT TVGWKGLIND PRIDGTFNVE
     EGLHIGRKLL LDLAEMGLPL ATEALDPMTP QYLADLFSWS AIGARTTESQ THRELASGLS
     MAVGFKNGTD GSLATAINAM KAASMGHSFI GINQQGQVNL LHTEGNPDGH VILRGGKKPN
     YQQEFVNQCE EELAKAGLET AIMIDCSHGN SNKDYKRQPS VAKDAVNQIV AGNKSIIGLM
     IESNINAGNQ SSEQKVSEMK YGVSITDACI DWETTDNLLR KIAAALKNRA E
//
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