ID Q66776_ERBV1 Unreviewed; 2589 AA.
AC Q66776;
DT 01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT 01-NOV-1996, sequence version 1.
DT 27-MAR-2024, entry version 160.
DE RecName: Full=Genome polyprotein {ECO:0000256|ARBA:ARBA00020107};
OS Equine rhinitis B virus 1 (strain Equine/Switzerland/P1436/71/1971)
OS (ERBV-1) (Equine rhinovirus type 2).
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Picornavirales; Picornaviridae; Caphthovirinae; Erbovirus; Erbovirus A.
OX NCBI_TaxID=650131 {ECO:0000313|EMBL:CAA65615.1};
OH NCBI_TaxID=9796; Equus caballus (Horse).
RN [1] {ECO:0000313|EMBL:CAA65615.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=P1436 /71 {ECO:0000313|EMBL:CAA65615.1};
RX PubMed=8760418;
RA Wutz G., Auer H., Nowotny N., Skern T., Kuechler E.;
RT "Equine Rhinovirus serotypes 1 and 2: relationship to each other and to
RT aphthoviruses and cardioviruses.";
RL J. Gen. Virol. 77:1719-1730(1996).
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004180}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004180}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004180}. Host cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004295}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004295}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004295}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
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DR EMBL; X96871; CAA65615.1; -; Genomic_RNA.
DR RefSeq; NP_653077.1; NC_003983.1.
DR SMR; Q66776; -.
DR GeneID; 944574; -.
DR KEGG; vg:944574; -.
DR SABIO-RK; Q66776; -.
DR Proteomes; UP000000405; Segment.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0044162; C:host cell cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0039618; C:T=pseudo3 icosahedral viral capsid; IEA:UniProtKB-KW.
DR GO; GO:0019028; C:viral capsid; IDA:CACAO.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0051259; P:protein complex oligomerization; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR GO; GO:0039707; P:virus-mediated pore formation in host cell membrane; IEA:UniProtKB-KW.
DR CDD; cd23193; ps-ssRNA_Picornaviridae; 1.
DR CDD; cd00205; rhv_like; 3.
DR Gene3D; 1.20.960.20; -; 1.
DR Gene3D; 2.60.120.20; -; 3.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 4.10.90.10; Capsid protein VP4 superfamily, Picornavirus; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 1.
DR InterPro; IPR015031; Capsid_VP4_Picornavir.
DR InterPro; IPR037080; Capsid_VP4_sf_Picornavirus.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR004004; Helic/Pol/Pept_Calicivir-typ.
DR InterPro; IPR000605; Helicase_SF3_ssDNA/RNA_vir.
DR InterPro; IPR014759; Helicase_SF3_ssRNA_vir.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR044067; PCV_3C_PRO.
DR InterPro; IPR000199; Peptidase_C3A/C3B_picornavir.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001676; Picornavirus_capsid.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR033703; Rhv-like.
DR InterPro; IPR001205; RNA-dir_pol_C.
DR InterPro; IPR007094; RNA-dir_pol_PSvirus.
DR InterPro; IPR029053; Viral_coat.
DR Pfam; PF00548; Peptidase_C3; 1.
DR Pfam; PF00680; RdRP_1; 1.
DR Pfam; PF00073; Rhv; 2.
DR Pfam; PF00910; RNA_helicase; 1.
DR Pfam; PF08935; VP4_2; 1.
DR PRINTS; PR00918; CALICVIRUSNS.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF88633; Positive stranded ssRNA viruses; 2.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS51874; PCV_3C_PRO; 1.
DR PROSITE; PS50507; RDRP_SSRNA_POS; 1.
DR PROSITE; PS51218; SF3_HELICASE_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Capsid protein {ECO:0000256|ARBA:ARBA00022561};
KW Covalent protein-RNA linkage {ECO:0000256|ARBA:ARBA00022520};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Host cytoplasm {ECO:0000256|ARBA:ARBA00023200};
KW Host cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00022488};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000000405};
KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484};
KW T=pseudo3 icosahedral capsid protein {ECO:0000256|ARBA:ARBA00022706};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transport {ECO:0000256|ARBA:ARBA00022448};
KW Viral attachment to host cell {ECO:0000256|ARBA:ARBA00022804};
KW Viral ion channel {ECO:0000256|ARBA:ARBA00023039};
KW Viral RNA replication {ECO:0000256|ARBA:ARBA00022953};
KW Virion {ECO:0000256|ARBA:ARBA00022706};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296}.
FT DOMAIN 1479..1645
FT /note="SF3 helicase"
FT /evidence="ECO:0000259|PROSITE:PS51218"
FT DOMAIN 1903..2108
FT /note="Peptidase C3"
FT /evidence="ECO:0000259|PROSITE:PS51874"
FT DOMAIN 2355..2472
FT /note="RdRp catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50507"
FT REGION 218..238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 774..797
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1274..1295
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2589 AA; 289559 MW; 761325CD72E8B9D8 CRC64;
MVTMAGNMIC NVFAGLATEI CSPKQGPLLD NELPLPLELA EFPNKDNNCW VAALSHYYTL
CDVTNHVTKV TPTTSGIRYY LTAWQSILQT DLFNGYYPAA FAVETGLCHG PFPMQQHGYV
RNATSHPYNF CLCSEPVPGE DYWHAVVKVD LSRTEARVDK WLCIDDDRMY LSGPPTRVKL
ASSYKIPTWI ESLAQFCLQL HPVQHRRTLA NSLRNEQCRG AGHSRPEGGH NNESGNNGTI
VNNYYMQHYQ NSVDLDGMTS QNIGGQPGSS SNPFSSILDI LGTASSVALL DQDTEDVTRQ
PDRIVTVLDG NTSRTTQSSV GILRGYNYAP GKHTQPSSAQ DTPSKAEQSV ERGFTFQLAQ
WETSRNIWDH LTIPLPMCPG LIKVSGMYKA FIETHAYIKN GWKIQVQCNA SQFHSGCLLV
AMIPEYLSTA QQDFLGSWRD KTTDSTPGTW VWNTYEAFPP GFPPQQITLF PHQFLNLRTN
TTVDLEVPYT NFAPSSSPTL HCPWTLVIVV VSPLQFGTGA PTQVQITTTI TPTDFVANGL
RQAVAQGIPG TQPYDRQFVS SEPSAPPPVY TPSWLPERSF IPGKFTDFLQ VAVIPTLAEV
SVQNYKPVPS FPVSNVLQTK PLVNTDLTFT SMTFRNTYVS ALSLQYTQYR GSICMDLLFT
GSAMCQGKFV VCYVPPGREP QSLDEAMQGT YSIWDLGLNS SFKFVVPYIS ASAYRFTHED
DQPSALNAVG WLQIYQLTNL TFPPNVPTRA DVLVFFSAGS DFCLRFPVDT YPRTEGTENM
ETGAVGPSDP SETSDSHSFA MPNVVSHTNL EFLFDRYFFS GFANSCDVTA NTTHTHSGDT
QLNPFVTPNF KLDKTVRDYM LRAFTYFTAD LGVAVQPTSV SSKPLPAVDY WVGWRPVGAP
EPKLLAFSAP SPGDTVTAVK RSSVLSGGFC PIIHSVIGQG LNQVQMSIPY TTPLSAIPTS
YCGYADYKKK PRLFGHPPAA HFGTLSIRVR NVDLLPEQTK KEDDPLVDLR FALFTRFRNL
KAYAPRPFTR VPNSPHEQGT ASRTLVRTNH ITAEFVEKTP LNGLAAVFTS LSTSGYSTKL
VSEPIPEATL STILSEGATN FSLLKLAGDV ELNPGPTIWS VMPGGELIEF ATKVSQVYKT
IKEKCTDPTT WIKAVRRLLR LLAVVSAWKH GDWFSMICLL VDLGFDLAQL SYKTFWQYLT
KPFADAGLKF DFARDLTRRF RREQPRAPEV SPEEQRMAYG ADFRQAVQYQ ENLQAPRRSW
RERAQDTYRS IRRTFFDDSS SESEDGEPEV PQFRPQVYPR PRSMRVVRHP MTARRAQRVI
DMGYSDYETA VENPFFISDL SSPEEEEPIP YEQARRQVPR VHFRESRGPE PTLRPRPGLM
HRLAQRVHCE ENQALLSEGI SSTLSVLNGF FNLFKNVQWF LDFLKSCYGK LSKQLKPMQS
LRDKVLQTYA DSIAEFMTPS AQKKELYLQN HYDAVEAGLN SIAAAWKDLA NKCYAYSRPE
PVCILLKGRA GQGKSVAATV IAKAVSIVNT GKESVWTLPT DSDFFDGYAG QNVVIIDDLG
QNPDGKDFRN FCQMVSSTVF LPPVADLAHK GIPFTSPVII ATTNKNENFL PVTVSDQEAV
TRRYWKVIDV SADDQYKTVD GRLDYAKATQ PTQIPPELAV FKTHVPLLKG ALRDCQRTNR
SGARVLNLYD VISAICVEVD RREQLRSNLG GIFAQSRDRH YQRDREYYDE YGTAEHRRRF
VEQNPTFHFK ETEADFYERV AFLSGIHGRK QSILKKIKEW FADGVRVRNL LGDAALALSL
LTSILSFSLV IYSGVKTYQE FSRKHKPVRQ PVYNAWEDFD EDCIFEQSRA YNIPNVRQRL
RKQLAVRAEN LCPSHDVTPD VEAHIPQGPV CEVDPGVPLV AQGASTGLTV NSLSLLNNVV
PVTVSTVIET ENGPLSQIVS ECCGTYLYNK VMIMPRHILI KDWTHITAGR NSATRDQLEA
VDVIDQFDMP SDAVAVKFPD KRGSSYKNIM HHLASTLPIR GKPVFILVNN NVAGRAVVHG
TYIGCTQKIT TLDGFTFPNV SSYKATTHLG MCGAPVIANE NGNGKIIGFH CAGTGLVGYA
SNLTKMSANN ICKVWGDPVA QGWTYFDTTH TPVHVPRKTK LRPTVAINTF ECDVEPAVLS
KFDRRLEEPD SFELTLLHKN DRRYPEDTSM DKHLEAAVEA YASSLFAQIG TDNGIISEYE
AVTGIENLDS VETTTSPGLP YTTAGIPREA LFDPDKTQLI GPAAERLQEF LRGDFSKHVF
QTFLKDELRS KAKVRAGNTR VVEVAAVDHV VAGRMLLGKF TAKMHANNGL GIGSAVGCNP
DVDFTRFAYQ ILEWDYVYDI DYKNFDASHS PKVFQYLKKL LSPENGFDVR LQKYIDSLCY
SKHQFGDTYY ECEGALPSGC SATSILNCLM NNIVLRAAAY DVFTNYEEGD LAFLTYGDDV
LLCANQPLPL ERFRKSLAKL GYTITPADKS SVFPEVSTLA DVVFLKRRFK PDEEFPFLFK
PVMDVRNLQD HLRYAKPGTL REKLLSTTDL AVHLGPLEYA RLFRPFVEVG YCVRAFGDAR
RAWLRNFDL
//
