ID Q66HY5_DANRE Unreviewed; 412 AA.
AC Q66HY5; A0A8N7UZF2;
DT 11-OCT-2004, integrated into UniProtKB/TrEMBL.
DT 11-OCT-2004, sequence version 1.
DT 27-MAR-2024, entry version 142.
DE SubName: Full=Early growth response 2b {ECO:0000313|EMBL:AAH81622.1};
DE SubName: Full=Early growth response protein 2b {ECO:0000313|Ensembl:ENSDARP00000062854, ECO:0000313|RefSeq:NP_571072.2};
GN Name=egr2b {ECO:0000313|EMBL:AAH81622.1,
GN ECO:0000313|Ensembl:ENSDARP00000062854,
GN ECO:0000313|RefSeq:NP_571072.2, ECO:0000313|ZFIN:ZDB-GENE-980526-283};
GN Synonyms=cb427 {ECO:0000313|RefSeq:NP_571072.2}, egr2
GN {ECO:0000313|RefSeq:NP_571072.2}, id:ibd5073
GN {ECO:0000313|RefSeq:NP_571072.2}, krox20
GN {ECO:0000313|RefSeq:NP_571072.2}, KRX-20
GN {ECO:0000313|RefSeq:NP_571072.2}, krx20
GN {ECO:0000313|RefSeq:NP_571072.2}, wu:fb71h10
GN {ECO:0000313|RefSeq:NP_571072.2}, zgc:92210
GN {ECO:0000313|RefSeq:NP_571072.2};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAH81622.1};
RN [1] {ECO:0000313|RefSeq:NP_571072.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=7687227;
RA Strahle U., Blader P., Henrique D., Ingham P.W.;
RT "Axial, a zebrafish gene expressed along the developing body axis, shows
RT altered expression in cyclops mutant embryos.";
RL Genes Dev. 7:1436-1446(1993).
RN [2] {ECO:0000313|RefSeq:NP_571072.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=7600994;
RA Kelly G.M., Greenstein P., Erezyilmaz D.F., Moon R.T.;
RT "Zebrafish wnt8 and wnt8b share a common activity but are involved in
RT distinct developmental pathways.";
RL Development 121:1787-1799(1995).
RN [3] {ECO:0000313|RefSeq:NP_571072.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=7555724;
RA Griffin K., Patient R., Holder N.;
RT "Analysis of FGF function in normal and no tail zebrafish embryos reveals
RT separate mechanisms for formation of the trunk and the tail.";
RL Development 121:2983-2994(1995).
RN [4] {ECO:0000313|RefSeq:NP_571072.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=7605750;
RA Hill J., Clarke J.D., Vargesson N., Jowett T., Holder N.;
RT "Exogenous retinoic acid causes specific alterations in the development of
RT the midbrain and hindbrain of the zebrafish embryo including positional
RT respecification of the Mauthner neuron.";
RL Mech. Dev. 50:3-16(1995).
RN [5] {ECO:0000313|RefSeq:NP_571072.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=7669688; DOI=10.1016/0925-4773(95)00360-D;
RA Hauptmann G., Gerster T.;
RT "Pou-2 -- a zebrafish gene active during cleavage stages and in the early
RT hindbrain.";
RL Mech. Dev. 51:127-138(1995).
RN [6] {ECO:0000313|EMBL:AAH81622.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Whole {ECO:0000313|EMBL:AAH81622.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|Ensembl:ENSDARP00000062854}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000062854};
RG Ensembl;
RL Submitted (FEB-2012) to UniProtKB.
RN [8] {ECO:0000313|Ensembl:ENSDARP00000062854, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000062854};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [9] {ECO:0000313|RefSeq:NP_571072.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30089266;
RA Asakawa K., Kawakami K.;
RT "Protocadherin-Mediated Cell Repulsion Controls the Central Topography and
RT Efferent Projections of the Abducens Nucleus.";
RL Cell Rep. 24:1562-1572(2018).
RN [10] {ECO:0000313|RefSeq:NP_571072.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30114527;
RA Zhang Z., Qin Z.;
RT "Characterization of Midkine in tongue sole (Cynoglossus semilaevis)and its
RT role on the germ layer genesis in zebrafish (Danio rerio).";
RL Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 226:64-72(2018).
RN [11] {ECO:0000313|RefSeq:NP_571072.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30089513;
RA Cunningham R.L., Herbert A.L., Harty B.L., Ackerman S.D., Monk K.R.;
RT "Mutations in dock1 disrupt early Schwann cell development.";
RL Neural Dev. 13:17-17(2018).
RN [12] {ECO:0000313|RefSeq:NP_571072.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30080860;
RA Torbey P., Thierion E., Collombet S., de Cian A., Desmarquet-Trin-Dinh C.,
RA Dura M., Concordet J.P., Charnay P., Gilardi-Hebenstreit P.;
RT "Cooperation, cis-interactions, versatility and evolutionary plasticity of
RT multiple cis-acting elements underlie krox20 hindbrain regulation.";
RL PLoS Genet. 14:e1007581-e1007581(2018).
RN [13] {ECO:0000313|RefSeq:NP_571072.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30472261;
RA Li J., Zhao Y., He L., Huang Y., Yang X., Yu L., Zhao Q., Dong X.;
RT "Znfl1s are essential for patterning the anterior-posterior axis of
RT zebrafish posterior hindbrain by acting as direct target genes of retinoic
RT acid.";
RL Mech. Dev. 155:27-33(2019).
RN [14] {ECO:0000313|RefSeq:NP_571072.2}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU363046}.
CC -!- SIMILARITY: Belongs to the EGR C2H2-type zinc-finger protein family.
CC {ECO:0000256|ARBA:ARBA00005682, ECO:0000256|RuleBase:RU363046}.
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DR EMBL; CR354434; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC081622; AAH81622.1; -; mRNA.
DR RefSeq; NP_571072.2; NM_130997.2.
DR Ensembl; ENSDART00000062855.5; ENSDARP00000062854.4; ENSDARG00000042826.5.
DR GeneID; 30190; -.
DR KEGG; dre:30190; -.
DR AGR; ZFIN:ZDB-GENE-980526-283; -.
DR CTD; 30190; -.
DR ZFIN; ZDB-GENE-980526-283; egr2b.
DR HOGENOM; CLU_043235_0_0_1; -.
DR OMA; QCQRELH; -.
DR OrthoDB; 2912670at2759; -.
DR TreeFam; TF318980; -.
DR Proteomes; UP000000437; Chromosome 12.
DR Bgee; ENSDARG00000042826; Expressed in regional part of brain and 44 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0009790; P:embryo development; IEA:UniProt.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 3.
DR InterPro; IPR021849; EGR_N.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR23235:SF54; E3 SUMO-PROTEIN LIGASE EGR2; 1.
DR PANTHER; PTHR23235; KRUEPPEL-LIKE TRANSCRIPTION FACTOR; 1.
DR Pfam; PF11928; DUF3446; 1.
DR Pfam; PF00096; zf-C2H2; 3.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE 2: Evidence at transcript level;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU363046};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU363046};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU363046};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU363046};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU363046};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU363046};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 299..328
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 329..356
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 357..384
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 268..299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 371..412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 387..412
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 412 AA; 45195 MW; 3A3C8C0DAC57B597 CRC64;
MTAKTLEKAP VSLGGFVHPL ADSIYSVDEL ATTLPASVTI YNDLGGHYEQ INAGDGLING
DMSTEKRALD LAYSSSFAQP AGPRNQTFTY MGKFSIDSQY PGNWNPEGVI NIVSAGILGM
TQPSSASSSP ASSVSPSHFS STLSCTMAQN QADMEHIYSP PPPYSGCGEV YQDPSAFLST
STCPISYPPP SYSSPKPNAD SGLFPIIPDY AGFFQPPCQR DMQSMPDRKP FSCPLDSFKL
PPPLTPLNTI RNFTLGGPVP DGPRLPTAYT PQNLPLRPIL RPRKYPNRPS KTPVHERPYP
CPAEGCDRRF SRSDELTRHI RIHTGHKPFQ CRICMRNFSR SDHLTTHIRT HTGEKPFACD
FCGRKFARSD ERKRHTKIHL RQKERKSSSS STGVSSSERG VATSICSSSS NQ
//
