ID Q66IF9_XENTR Unreviewed; 460 AA.
AC Q66IF9; F6YG17;
DT 11-OCT-2004, integrated into UniProtKB/TrEMBL.
DT 11-OCT-2004, sequence version 1.
DT 27-MAR-2024, entry version 134.
DE SubName: Full=55 kDa erythrocyte membrane protein {ECO:0000313|RefSeq:NP_001008152.1};
DE SubName: Full=MGC89895 protein {ECO:0000313|EMBL:AAH81365.1};
DE SubName: Full=Membrane protein, palmitoylated 1 {ECO:0000313|Ensembl:ENSXETP00000034012};
DE SubName: Full=Sphingolipid delta(4)-desaturase DES1 {ECO:0000313|Ensembl:ENSXETP00000040228};
GN Name=mpp1 {ECO:0000313|Ensembl:ENSXETP00000034012,
GN ECO:0000313|RefSeq:NP_001008152.1,
GN ECO:0000313|Xenbase:XB-GENE-5787649};
GN Synonyms=degs1 {ECO:0000313|Ensembl:ENSXETP00000040228}, MGC89895
GN {ECO:0000313|EMBL:AAH81365.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|EMBL:AAH81365.1};
RN [1] {ECO:0000313|RefSeq:NP_001008152.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAH81365.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000313|EMBL:AAH81365.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSXETP00000034012}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000034012};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [4] {ECO:0000313|Ensembl:ENSXETP00000040228}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2019) to UniProtKB.
RN [5] {ECO:0000313|RefSeq:NP_001008152.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the MAGUK family.
CC {ECO:0000256|ARBA:ARBA00007014}.
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DR EMBL; BC081365; AAH81365.1; -; mRNA.
DR RefSeq; NP_001008152.1; NM_001008151.2.
DR STRING; 8364.ENSXETP00000040228; -.
DR PaxDb; 8364-ENSXETP00000034012; -.
DR PaxDb; 8364-ENSXETP00000039206; -.
DR DNASU; 493514; -.
DR Ensembl; ENSXETT00000034012; ENSXETP00000034012; ENSXETG00000015590.
DR Ensembl; ENSXETT00000040228; ENSXETP00000040228; ENSXETG00000018586.
DR GeneID; 493514; -.
DR KEGG; xtr:493514; -.
DR AGR; Xenbase:XB-GENE-5787649; -.
DR CTD; 4354; -.
DR Xenbase; XB-GENE-946874; degs1.
DR Xenbase; XB-GENE-5787649; mpp1.
DR eggNOG; KOG0609; Eukaryota.
DR HOGENOM; CLU_001715_5_1_1; -.
DR OMA; KETQGMV; -.
DR OrthoDB; 2873706at2759; -.
DR TreeFam; TF314263; -.
DR Proteomes; UP000008143; Chromosome 4.
DR Bgee; ENSXETG00000015590; Expressed in liver and 20 other cell types or tissues.
DR CDD; cd00071; GMPK; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23122:SF37; 55 KDA ERYTHROCYTE MEMBRANE PROTEIN; 1.
DR PANTHER; PTHR23122; MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50002; SH3; 1.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 69..150
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 156..224
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 277..445
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
SQ SEQUENCE 460 AA; 51399 MW; AAFCCEA8C7D0F000 CRC64;
MSMKFERAET PLCDSSSVRT ALSDLYLETL LQNRGSAKGY QTSVGSHTEE IYTNGSAASG
TEEKKRVRLV QFERETEEPM GITLKVNSQQ SCIVARILHG GFIHRQGSLH VGDEILEING
KSVRNQSVDH LQSVLKESKG TVVLKVSPSQ SNRKPPLQMY VRALFDYNPL SDTLIPCREA
GLAFHTGDIL QIINKDDSNW WQGRLQGEGS AGLIPSPELQ EWRVASSSTT NQNPQSCSPF
SKKKKCKDKY LAKHSSIFDQ LDVVSYEEVV SLPAFTRKTL VLIGVSGVGR SHIKNTLLAK
YPERFVYPAP HTSRPPKRGE EESGSYHFVS AEEMSRAISE NEFLEYGSFS GYMFGTKIQT
VKEVHKDGKV AILDIEPQTL KMVRTAELAP FIVFISPTDK EESEALQKLR ADSDVLRSRY
AQHFDLTLVN NGVEQTVQDL LEAFDAACSS PQWVPVTWVY
//
