ID Q66J29_XENLA Unreviewed; 979 AA.
AC Q66J29;
DT 11-OCT-2004, integrated into UniProtKB/TrEMBL.
DT 11-OCT-2004, sequence version 1.
DT 27-MAR-2024, entry version 129.
DE RecName: Full=Mineralocorticoid receptor {ECO:0000256|ARBA:ARBA00039945};
DE AltName: Full=Nuclear receptor subfamily 3 group C member 2 {ECO:0000256|ARBA:ARBA00042670};
GN Name=nr3c2.L {ECO:0000313|RefSeq:NP_001084074.1,
GN ECO:0000313|Xenbase:XB-GENE-483089};
GN Synonyms=mlr {ECO:0000313|RefSeq:NP_001084074.1}, Nr3c2
GN {ECO:0000313|EMBL:AAH81082.1}, nr3c2
GN {ECO:0000313|RefSeq:NP_001084074.1,
GN ECO:0000313|Xenbase:XB-GENE-483089};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|EMBL:AAH81082.1};
RN [1] {ECO:0000313|RefSeq:NP_001084074.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=7740172;
RA Csikos T., Tay J., Danielsen M.;
RT "Expression of the Xenopus laevis mineralocorticoid receptor during
RT metamorphosis.";
RL Recent Prog. Horm. Res. 50:393-396(1995).
RN [2] {ECO:0000313|RefSeq:NP_001084074.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [3] {ECO:0000313|EMBL:AAH81082.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney {ECO:0000313|EMBL:AAH81082.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|RefSeq:NP_001084074.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; BC081082; AAH81082.1; -; mRNA.
DR RefSeq; NP_001084074.1; NM_001090605.1.
DR STRING; 8355.Q66J29; -.
DR PaxDb; 8355-Q66J29; -.
DR GeneID; 399290; -.
DR KEGG; xla:399290; -.
DR AGR; Xenbase:XB-GENE-483089; -.
DR CTD; 399290; -.
DR Xenbase; XB-GENE-483089; nr3c2.L.
DR OMA; ITFPKME; -.
DR OrthoDB; 5350431at2759; -.
DR Proteomes; UP000186698; Chromosome 1L.
DR Bgee; 399290; Expressed in camera-type eye and 18 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd07172; NR_DBD_GR_PR; 1.
DR CDD; cd07075; NR_LBD_MR; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR48092; KNIRPS-RELATED PROTEIN-RELATED; 1.
DR PANTHER; PTHR48092:SF19; MINERALOCORTICOID RECEPTOR; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Receptor {ECO:0000256|ARBA:ARBA00023170,
KW ECO:0000313|RefSeq:NP_001084074.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 597..672
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 717..959
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 110..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 241..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 677..715
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..35
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 114..134
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 686..715
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 979 AA; 106981 MW; F0D41A4F27702395 CRC64;
METKGYKNFQ EGVNMERQWG QVPRDFSSPN SRQQTPENTY MEIVNVNCDS DSFPQNNAKA
DSKEKQDLLP CLQQDSSKPS LLTQELKPEL ESKELSAAVA ESMGLYMDSV RDSDYPYDQQ
NQQGTNGSGT IFQSMNPFYK QTTQGTFPAD CQTRSLRSAI ESDKSMNGKL KSNTVKSPLS
YSEKNLSVGS PSVMALPVCS PTGISSTSCS TTFGNFTVHS PVNQVTPKSC SPHTDNRCSI
AHSPAGTVES PLSSPVSSMR SPISSPPSHA SLKSPVSSPN NITVRPSVSS PGNINTRSSL
SSPSNANNRS TISSPAASSM GSSICSPASS TLGFLPGVMP TDGGTASDGI ISAETKDKGA
QQIMFPKVEE MGNEIADSTV SLVKFIKPDP DAIFSSTCFG DTVSSDPAFS IPIKQESCKN
TCSSALFKGS QSANPFPFMD GSYFAFMDDK DYYSLSGILG PPVSSFGDGF EGNGFSNQSL
NVAIKQETED SSFYPENNMP SSAIVGVNSC GQSFHYRIGA QGTISLSRPL NRDQSFQNLS
SFPPMSSLVE SWKTQSELAQ NTLSSRRNDG FPVPGYIPEN MSSTTLRSMS TGPSRPSKVC
LVCGDEASGC HYGVVTCGSC KVFFKRAVEG QHSYLCAGRN DCIIDKIRRK NCPACRLQKC
LQAGMNLGAR KSKKLGKLKG VHEEHPQQPL QQTPTASPKE DTTLTSSSKE PSANSNSLVP
LISAVSPAIT LSAAVILENI EPEIVYAGYD NTQPDTAENL LSSLNQLAGK QMVQVVKWAK
VIPGFRNLPL EDQITLIQYS WMCLSSFALS WRSYKHASSQ FLYFAPDLIF NEERMRQSAM
YDLCQGMQQI SLEFSRLQLT FEEYTLMKVL LLLSTVPKDG LKCQAAFEEM RVNYIKELRK
VLLKSPHNSG QSWQRYFQLT KLLDSMQDLV GDLLEFCFYT FRESQALKVE FPAMLVEIIS
DQLPKVESGI AKPLYFHRK
//
