ID   Q67TD8_SYMTH            Unreviewed;       740 AA.
AC   Q67TD8;
DT   11-OCT-2004, integrated into UniProtKB/TrEMBL.
DT   11-OCT-2004, sequence version 1.
DT   27-MAR-2024, entry version 78.
DE   SubName: Full=Penicillin amidase {ECO:0000313|EMBL:BAD39055.1};
GN   OrderedLocusNames=STH70 {ECO:0000313|EMBL:BAD39055.1};
OS   Symbiobacterium thermophilum (strain T / IAM 14863).
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Symbiobacteriaceae;
OC   Symbiobacterium.
OX   NCBI_TaxID=292459 {ECO:0000313|EMBL:BAD39055.1, ECO:0000313|Proteomes:UP000000417};
RN   [1] {ECO:0000313|EMBL:BAD39055.1, ECO:0000313|Proteomes:UP000000417}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=T / IAM 14863 {ECO:0000313|Proteomes:UP000000417};
RX   PubMed=15383646; DOI=10.1093/nar/gkh830;
RA   Ueda K., Yamashita A., Ishikawa J., Shimada M., Watsuji T., Morimura K.,
RA   Ikeda H., Hattori M., Beppu T.;
RT   "Genome sequence of Symbiobacterium thermophilum, an uncultivable bacterium
RT   that depends on microbial commensalism.";
RL   Nucleic Acids Res. 32:4937-4944(2004).
CC   -!- SIMILARITY: Belongs to the peptidase S45 family.
CC       {ECO:0000256|ARBA:ARBA00006586}.
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DR   EMBL; AP006840; BAD39055.1; -; Genomic_DNA.
DR   RefSeq; WP_011194205.1; NC_006177.1.
DR   AlphaFoldDB; Q67TD8; -.
DR   STRING; 292459.STH70; -.
DR   KEGG; sth:STH70; -.
DR   eggNOG; COG2366; Bacteria.
DR   HOGENOM; CLU_011790_0_1_9; -.
DR   OrthoDB; 9759796at2; -.
DR   Proteomes; UP000000417; Chromosome.
DR   GO; GO:0016811; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; IEA:InterPro.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.60.20.10; Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1; 3.
DR   Gene3D; 1.10.439.10; Penicillin Amidohydrolase, domain 1; 1.
DR   InterPro; IPR029055; Ntn_hydrolases_N.
DR   InterPro; IPR014395; Pen/GL7ACA/AHL_acylase.
DR   InterPro; IPR023343; Penicillin_amidase_dom1.
DR   InterPro; IPR002692; S45.
DR   PANTHER; PTHR34218:SF4; ACYL-HOMOSERINE LACTONE ACYLASE QUIP; 1.
DR   PANTHER; PTHR34218; PEPTIDASE S45 PENICILLIN AMIDASE; 1.
DR   Pfam; PF01804; Penicil_amidase; 2.
DR   PIRSF; PIRSF001227; Pen_acylase; 2.
DR   SUPFAM; SSF56235; N-terminal nucleophile aminohydrolases (Ntn hydrolases); 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000000417}.
SQ   SEQUENCE   740 AA;  78604 MW;  3C974A5FFC5A3DD3 CRC64;
     MLRLFGLAGA IFVVLLLAAL ATGAPVLHAL ALLTGLAAAA ALAGLQLSRP QGRGTVRMDG
     LRAPAAVRRD EGGAPHIAAE NWHDLFQAQG FVAAQERLWQ MEVARRTAAG RLAELCGESC
     LERDRFMRAL GLYRLAERAL ADCPDEVRAC LEAYADGVNA FIRAGKLPPE FALARLRPEP
     WRAVDSLAVA KLLAFELAPP VADVVVRARV AQVAGPEMAA ALYAPGPSDA SPPDPQQLPD
     LGGLCRLAMW APQTVSGGTA WALAGTRTES GLPIAGCSLE TAPRAPSPLH PLTLHGPGGA
     RLEGIALAGL PGLLVGQSRH FAWALAPSEG GTARLVPEPS EGVRSQLTAI RVRGRAEPVA
     HTVLIGHSGP VVAMDESGAA ALRSPVLQPG QEVAALLGIN LARSYEEFRD AVREWAVPGL
     TVIYAGVDGT VARLETGPEL REEVNPEDGI ALGGRPADAA ARIREVAASR TGWTLPFLAR
     LPGDTVNMQA RNLLQPLLQT LQEGLRQGAR PESLTELEKR ALLLLSDWSH EEPAGSAGAC
     LWERWYFDLV EAIFRPRLGL TLFNQFIMTP SGQGAAEQLI LRALRGEESP WLPLEGEFGL
     PRLALSAFRR AVAYLAARQG RSPERWAWGR EHRVRFRHSL AEALPALGPL ADLGPHPLGG
     GPATLHRSGL DPTMSGTVTT ATTYCRLVDL ARPGEPVAVL APGTGGHPLD PSFAAQLLPW
     LRGDLLPPRP TGEDVLRLVP
//