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Database: UniProt
Entry: Q688B2_CAEEL
LinkDB: Q688B2_CAEEL
Original site: Q688B2_CAEEL 
ID   Q688B2_CAEEL            Unreviewed;      1861 AA.
AC   Q688B2;
DT   11-OCT-2004, integrated into UniProtKB/TrEMBL.
DT   11-OCT-2004, sequence version 1.
DT   28-FEB-2018, entry version 117.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:CCD64246.1};
GN   Name=unc-77 {ECO:0000313|EMBL:CCD64246.1,
GN   ECO:0000313|WormBase:C11D2.6d};
GN   ORFNames=C11D2.6 {ECO:0000313|WormBase:C11D2.6d}, CELE_C11D2.6
GN   {ECO:0000313|EMBL:CCD64246.1};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD64246.1, ECO:0000313|Proteomes:UP000001940};
RN   [1] {ECO:0000313|EMBL:CCD64246.1, ECO:0000313|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD64246.1,
RC   ECO:0000313|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=https://doi.org/10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RA   Sulson J.E., Waterston R.;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology.";
RL   Science 282:2012-2018(1998).
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DR   EMBL; BX284604; CCD64246.1; -; Genomic_DNA.
DR   RefSeq; NP_741413.2; NM_171352.3.
DR   UniGene; Cel.17060; -.
DR   ProteinModelPortal; Q688B2; -.
DR   EnsemblMetazoa; C11D2.6d; C11D2.6d; WBGene00006809.
DR   GeneID; 177379; -.
DR   UCSC; C11D2.6d; c. elegans.
DR   CTD; 177379; -.
DR   WormBase; C11D2.6d; CE37196; WBGene00006809; unc-77.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   HOGENOM; HOG000012967; -.
DR   Reactome; R-CEL-2672351; Stimuli-sensing channels.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00006809; -.
DR   ExpressionAtlas; Q688B2; baseline and differential.
DR   GO; GO:0030424; C:axon; IDA:WormBase.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005261; F:cation channel activity; IDA:WormBase.
DR   GO; GO:0040017; P:positive regulation of locomotion; IGI:WormBase.
DR   GO; GO:0032224; P:positive regulation of synaptic transmission, cholinergic; IGI:WormBase.
DR   GO; GO:0032230; P:positive regulation of synaptic transmission, GABAergic; IGI:WormBase.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   Pfam; PF00520; Ion_trans; 4.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001940};
KW   Membrane {ECO:0000256|SAAS:SAAS00085096, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00084820,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00084701,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    151    172       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    192    208       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    229    249       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    339    359       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    429    452       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    464    488       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    553    576       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    622    646       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    924    949       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    969    992       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1004   1021       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1066   1088       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1180   1206       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1261   1281       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1293   1313       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1333   1351       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1367   1384       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1405   1429       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1490   1508       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       86    376       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      429    651       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      930   1210       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1260   1527       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      849    872       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1861 AA;  215056 MW;  08365F29158D1A0E CRC64;
     MSERKKSLIT TINNQRKYSQ VAKAAVLSSA MLARKNSSSR GAPGSAAGFG ARESIAAISD
     MLSSQHKKPV RSSYVESDRV EWALKIACTI SMITVCIHTP RTIELFQPLN YIILAADFIS
     VSIFMLDSVL RIHYEGIFRC DSSYLSNRWS QFSVFISIIH LLSFLLHCYQ LIDNFFPFLH
     LNYRAWYGAI RSIRPFIIIR LIPLVVKFKL PKNRIEQLLK RSSQQVKNVT LFFVFFMTLY
     AIFGIQLFGR MDYHCVQPKT DPNNVTIMDL AIPDTMCAPE GIGGYECPAP MVCMQLNLNA
     KGEGFYGMFN DFGASVFTVY LAASEEGWVY VLYDCMDSLP SYLAFLYFCT LIFFLAWLVK
     NVFIAVITET FAEIRVQFSE MWQKKEVTLD EGFRKKLEKT DDGWRLIRLD GEVEPEGPKQ
     KLQWMLRSMY FQCFVIIFVV INAIGNAMFV YRHDETDKPR KYNFYLFEVG FTILFNVECI
     IKILCYGFRN FIRRGIFKFE LILCLGSSLN CVKFFYERNY FTYFQTFRLL RLIKASPILE
     DFVWKIFSPG KKLGGLVIFT IAFICCYSAI SLQLFYSVPN LHHFRTFPQA FMSMFQIITQ
     EGWTDFVVEV LRATDDNLVP LVALYFVAYH LFVTLIVLSL FVAVILDNLE MDEELKKVKQ
     LRAREATTSM RSTLPWRLRV FEKFPTRPQM AAMRKADSDF PMPKVRGSFT HQFAVDHSLE
     TTDVIESDFE FPKRIMKSAG KRKISKSGLT FRQIGSTSLR CSLNNLLEMS DRTRQSLSNS
     LSFLPHFTRS SGSLYPRKDA LPKSRSMTGK FLQTAVRNKQ FNMYSENGDL SRPSDSAPKK
     NAKQGEIDIR ALQQKRQLAE ITRNRIEEDM RENHPFFDRP LFLVGRASQL REFCKKMVHS
     KYDSQDDGTN GGAKTKKRFK EIRALIGIMP YIDWAMATVT IVSCISMLFE SPWPTTGENL
     VMNNGYLQIS DYFFVLSMTF ELCVKIIANG LFFTPKAVVR DVGGVMNLFI YFTSVIFLAW
     MPKHVEINSL AQFLMICRAM RPLRIYTLVP HIRRVVLEFF RGFKEILLVT ILMIVVMFIF
     ASFGVQIVGG KLAACNDPTV SSRENCTGVF WQKLFVTRLE VYGKDTEAMH PKIMVPRVWT
     NPRNFNFDHV GNAMLALFET LSFKGWNVIR DILWSRHGPW AVVFIHIYVF IGCMIGLTLF
     VGVVIANYTQ NRGTALLTVD QRRWHDLKAR LKMAQPLHVP PKPSESARLR TKLYDLTMSR
     WFNQAFALLV VLNSFTLVIP WNVEEEEQRA TYVFTVTALA AFMNMLFVIE IILKVIAYTF
     SGFWQSRRNR VDLLITVFGV IWIFLHFFVA LPSSKIDVDV QVELKKFTYT FGYLVVILRF
     FTIASRNSTL KMLMLTVIMS MFRSFFIITA LFLLVLFYAY TGVILFPMVK YGMAVSKHVN
     FRTASEALVV LFRCLTGEDW NDIMHDCMRS APFCYWNEGM NYWETDCGNF YGAIIYFCSF
     YLIITYIVRN LLVAVIMENF SLFYSSEEDA LLSYADIRNF QYVWNMVDQE QKRTIPVERV
     KFLLRLLKGR LEVDPEKDRI LFKHMCYEME RLHNGEEVSF HDVLYMLSYR SVDIRKSLQL
     EELLQREELE FIIEEEVAKQ TIRTWLEGCL RKMRNPSQKD AEGVLPFGGG HPVIHSSGHS
     SISHEETVAQ RLRFENIRGD SVDTEETESS EEETPPPIRK KAAVKNRRGS IPDVLSRTGL
     FQEAARKFMV GSSSEKKQVK SRSPETVQLL PKRANSEIRK GSGQPKNFHL QLNVYDLPDV
     EERGEDSPFS PKNLSDDFNG EHSPLVITPS LPVPPTHGSP RPLMPCETTK DIEKWWNSLV
     D
//
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