ID Q68KG0_XENLA Unreviewed; 494 AA.
AC Q68KG0;
DT 11-OCT-2004, integrated into UniProtKB/TrEMBL.
DT 11-OCT-2004, sequence version 1.
DT 27-MAR-2024, entry version 108.
DE SubName: Full=Growth differentiation factor 5 L homeolog precursor {ECO:0000313|RefSeq:NP_001086466.1};
DE SubName: Full=Growth factor GDF5 {ECO:0000313|EMBL:AAT99303.1};
GN Name=gdf5.L {ECO:0000313|RefSeq:NP_001086466.1,
GN ECO:0000313|Xenbase:XB-GENE-481788};
GN Synonyms=CDMP1 {ECO:0000313|RefSeq:NP_001086466.1}, gdf
GN {ECO:0000313|RefSeq:NP_001086466.1}, gdf-5
GN {ECO:0000313|RefSeq:NP_001086466.1}, gdf5
GN {ECO:0000313|EMBL:AAT99303.1, ECO:0000313|RefSeq:NP_001086466.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|EMBL:AAT99303.1};
RN [1] {ECO:0000313|RefSeq:NP_001086466.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAT99303.1, ECO:0000313|RefSeq:NP_001086466.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Limb {ECO:0000313|EMBL:AAT99303.1};
RX PubMed=16829522; DOI=10.1074/jbc.M603851200;
RA Thomas J.T., Prakash D., Weih K., Moos M J.r.;
RT "CDMP1/GDF5 has specific processing requirements that restrict its action
RT to joint surfaces.";
RL J. Biol. Chem. 281:26725-26733(2006).
RN [3] {ECO:0000313|EMBL:AAI69412.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Oocytes {ECO:0000313|EMBL:AAI69412.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|RefSeq:NP_001086466.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25446275;
RA Square T., Jandzik D., Cattell M., Coe A., Doherty J., Medeiros D.M.;
RT "A gene expression map of the larval Xenopus laevis head reveals
RT developmental changes underlying the evolution of new skeletal elements.";
RL Dev. Biol. 397:293-304(2015).
RN [5] {ECO:0000313|RefSeq:NP_001086466.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; BC169412; AAI69412.1; -; mRNA.
DR EMBL; AY685227; AAT99303.1; -; mRNA.
DR RefSeq; NP_001086466.1; NM_001092997.1.
DR STRING; 8355.Q68KG0; -.
DR PaxDb; 8355-Q68KG0; -.
DR GeneID; 446295; -.
DR KEGG; xla:446295; -.
DR AGR; Xenbase:XB-GENE-481788; -.
DR CTD; 446295; -.
DR Xenbase; XB-GENE-481788; gdf5.L.
DR OMA; WHLTWLD; -.
DR OrthoDB; 2912454at2759; -.
DR Proteomes; UP000186698; Chromosome 9_10L.
DR Bgee; 446295; Expressed in internal ear and 3 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd19399; TGF_beta_GDF5; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF44; GROWTH_DIFFERENTIATION FACTOR 5; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR PRINTS; PR00669; INHIBINA.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 2: Evidence at transcript level;
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|SAM:SignalP, ECO:0000313|RefSeq:NP_001086466.1}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..494
FT /evidence="ECO:0000256|SAM:SignalP,
FT ECO:0000313|RefSeq:NP_001086466.1"
FT /id="PRO_5033206894"
FT DOMAIN 371..494
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 98..124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 494 AA; 56010 MW; 41B77B833DA4C3D1 CRC64;
MKVLKYIPLL LWYLIWDYLD LVPLVLGHSE QSHPGTKVGI AVTGGKERHP LPKVNATRTG
ILGHGLQKGR TKVPLVQSRI FLSKNEDIKK QAGNRAIPHA KNGNVENRQS GVKIGTPRPP
HVTSKASTKL INIHADSAGF KPKRPLNPLT EKEQKDIFKH QLITPHEYML SLYRTLSDVE
RKGINGSLKL EAGLANTITS FVDKGQDERM AAARKQKYVF DISALEKDGL LGAELRILRK
RPTDTKFNIA GKLSQIKLYS CPANKKSASL LDSRPLSSID TPKWEVFDIW KLYKNFKNSA
QLCFELEVMD KGKPADLRSV GFNRTGRPTN EKAIFLVFGR TKKRDLFFNE IKARSGQDDK
TVYEYLFNQR RKRRAPLSTR QGKRPNKNSK ARCSKKPLHV NFKDMGWDDW IIAPLEYEAY
HCEGLCEFPL RSHLEPTNHA VIQTLMNSMD PETTPPTCCV PTRLSPISIL YTDSANNVVY
KQYEDMVVES CGCR
//
