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Database: UniProt
Entry: Q69UP6
LinkDB: Q69UP6
Original site: Q69UP6 
ID   AGO18_ORYSJ             Reviewed;        1088 AA.
AC   Q69UP6; Q0D6K0;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   16-OCT-2019, entry version 85.
DE   RecName: Full=Protein argonaute 18;
DE            Short=OsAGO18;
GN   Name=AGO18; OrderedLocusNames=Os07g0471300, LOC_Os07g28850;
GN   ORFNames=OJ1103_E04.115, P0675B10.105;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H.,
RA   McCombie W.R., Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S.,
RA   Childs K.L., Davidson R.M., Lin H., Quesada-Ocampo L.,
RA   Vaillancourt B., Sakai H., Lee S.S., Kim J., Numa H., Itoh T.,
RA   Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using
RT   next generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 346-1088.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
RN   [5]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=18826656; DOI=10.1186/1471-2164-9-451;
RA   Kapoor M., Arora R., Lama T., Nijhawan A., Khurana J.P., Tyagi A.K.,
RA   Kapoor S.;
RT   "Genome-wide identification, organization and phylogenetic analysis of
RT   dicer-like, argonaute and RNA-dependent RNA polymerase gene families
RT   and their expression analysis during reproductive development and
RT   stress in rice.";
RL   BMC Genomics 9:451-451(2008).
CC   -!- FUNCTION: Probably involved in the RNA silencing pathway. May bind
CC       to short RNAs such as microRNAs (miRNAs) or short interfering RNAs
CC       (siRNAs), and represses the translation of mRNAs which are
CC       complementary to them (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the argonaute family. Ago subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AK069685; Type=Frameshift; Evidence={ECO:0000305};
CC       Sequence=BAF21523.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
DR   EMBL; AP003806; BAD30270.1; -; Genomic_DNA.
DR   EMBL; AP004347; BAD30662.1; -; Genomic_DNA.
DR   EMBL; AP008213; BAF21523.2; ALT_SEQ; Genomic_DNA.
DR   EMBL; AP014963; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AK069685; -; NOT_ANNOTATED_CDS; mRNA.
DR   RefSeq; XP_015644916.1; XM_015789430.1.
DR   SMR; Q69UP6; -.
DR   STRING; 4530.OS07T0471300-01; -.
DR   PaxDb; Q69UP6; -.
DR   PRIDE; Q69UP6; -.
DR   GeneID; 4343201; -.
DR   KEGG; osa:4343201; -.
DR   eggNOG; KOG1041; Eukaryota.
DR   eggNOG; ENOG410XP07; LUCA.
DR   HOGENOM; HOG000116043; -.
DR   InParanoid; Q69UP6; -.
DR   KO; K11593; -.
DR   Proteomes; UP000059680; Chromosome 7.
DR   Genevisible; Q69UP6; OS.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0031047; P:gene silencing by RNA; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.420.10; -; 1.
DR   InterPro; IPR014811; ArgoL1.
DR   InterPro; IPR032472; ArgoL2.
DR   InterPro; IPR032473; Argonaute_Mid_dom.
DR   InterPro; IPR032474; Argonaute_N.
DR   InterPro; IPR003100; PAZ_dom.
DR   InterPro; IPR036085; PAZ_dom_sf.
DR   InterPro; IPR003165; Piwi.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF08699; ArgoL1; 1.
DR   Pfam; PF16488; ArgoL2; 1.
DR   Pfam; PF16487; ArgoMid; 1.
DR   Pfam; PF16486; ArgoN; 1.
DR   Pfam; PF02170; PAZ; 1.
DR   Pfam; PF02171; Piwi; 1.
DR   SMART; SM01163; DUF1785; 1.
DR   SMART; SM00949; PAZ; 1.
DR   SMART; SM00950; Piwi; 1.
DR   SUPFAM; SSF101690; SSF101690; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS50821; PAZ; 1.
DR   PROSITE; PS50822; PIWI; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Reference proteome; RNA-mediated gene silencing.
FT   CHAIN         1   1088       Protein argonaute 18.
FT                                /FTId=PRO_0000378441.
FT   DOMAIN      458    574       PAZ. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00142}.
FT   DOMAIN      747   1056       Piwi. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00150}.
FT   COMPBIAS      5    205       Gly-rich.
FT   CONFLICT    511    511       R -> S (in Ref. 4; AK069685).
FT                                {ECO:0000305}.
FT   CONFLICT    587    587       V -> A (in Ref. 4; AK069685).
FT                                {ECO:0000305}.
SQ   SEQUENCE   1088 AA;  118035 MW;  F18920070EE050CA CRC64;
     MASRGGGQHQ RHQQQQQQPG GYGRGGGGGR GRGRDGAPYS GGRGRGQDGS YPGGRGGGYG
     GGGGGGGPPY YGGGGGGGGG GGGQGRGYYD DGGDGRGYQR GMEGGGGRGG YRGDGDGGYG
     RGGGGYHGDG ERGYGRGGGG GGGGGGGYRG DDEGRSSYGR ARGGGGGGGG YHGDGEAGYG
     RGRGGRDYDG GRGGGGRRGG RGGGGSSYHQ QPPPDLPQAP EPRLAAQYAR EIDIAALRAQ
     FKGLTTTTPG AASSQFPARP GFGAAGEECL VKVNHFFVGL KNDNFHHYDV AIAPDPVLKG
     LFRTIISKLV TERRHTDFGG RLPVYDGRAN LYTAGELPFR SRELEVELSG SRKFKVAIRH
     VAPVSLQDLR MVMAGCPAGI PSQALQLLDI VLRDMVLAER NDMGYVAFGR SYFSPGLGSR
     ELDKGIFAWK GFYQSCRVTQ QGLSLNIDMS STAFIEPGRV LNFVEKAIGR RITNAITVGY
     FLNNYGNELM RTLKGVKVEV THRGNLRKKY RIAGFTEQSA DVQTFTSSDG IKTVKEYFNK
     KYNLKLAFGY LPCLQVGSKE RPNYLPMELC NIVPGQRYKN RLSPTQVSNL INITNDRPCD
     RESSIRQTVS SNQYNSTERA DEFGIEVDSY PTTLKARVLK APMLKYHDSG RVRVCTPEDG
     AWNMKDKKVV NGATIKSWAC VNLCEGLDNR VVEAFCLQLV RTSKITGLDF ANVSLPILKA
     DPHNVKTDLP MRYQEACSWS RDNKIDLLLV VMTDDKNNAS LYGDVKRICE TEIGVLSQCC
     RAKQVYKERN VQYCANVALK INAKAGGRNS VFLNVEASLP VVSKSPTIIF GADVTHPGSF
     DESTPSIASV VASADWPEVT KYNSVVRMQA SRKEIIQDLD SIVRELLNAF KRDSKMEPKQ
     LIFYRDGVSE GQFQQVVESE IPEIEKAWKS LYAGKPRITF IVVQKRHHTR LFPNNYNDPR
     GMDGTGNVRP GTVVDTVICH PREFDFFLCS QAGIKGTSRP SHYHVLRDDN NFTADQLQSV
     TNNLCYLYTS CTRSVSIPPP VYYAHKLAFR ARFYLTQVPV AGGDPGAAKF QWVLPEIKEE
     VKKSMFFC
//
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