ID Q6A2A9_CHICK Unreviewed; 772 AA.
AC Q6A2A9;
DT 13-SEP-2004, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2004, sequence version 1.
DT 27-MAR-2024, entry version 117.
DE SubName: Full=Transcription factor LSox5-II {ECO:0000313|EMBL:CAF25288.1};
GN Name=SOX5 {ECO:0000313|EMBL:CAF25288.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|EMBL:CAF25288.1};
RN [1] {ECO:0000313|EMBL:CAF25288.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Whole embryo {ECO:0000313|EMBL:CAF25288.1};
RX PubMed=15306568; DOI=10.1242/dev.01329;
RA Perez-Alcala S., Nieto M.A., Barbas J.A.;
RT "LSox5 regulates RhoB expression in the neural tube and promotes generation
RT of the neural crest.";
RL Development 131:4455-4465(2004).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AJ626988; CAF25288.1; -; mRNA.
DR RefSeq; XP_015145682.1; XM_015290196.1.
DR AlphaFoldDB; Q6A2A9; -.
DR SMR; Q6A2A9; -.
DR STRING; 9031.ENSGALP00000043607; -.
DR VEuPathDB; HostDB:geneid_418195; -.
DR eggNOG; KOG0528; Eukaryota.
DR HOGENOM; CLU_018522_0_0_1; -.
DR InParanoid; Q6A2A9; -.
DR Bgee; ENSGALG00000032768; Expressed in testis and 13 other cell types or tissues.
DR ExpressionAtlas; Q6A2A9; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0045165; P:cell fate commitment; IBA:GO_Central.
DR GO; GO:0032332; P:positive regulation of chondrocyte differentiation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd22042; HMG-box_EGL13-like; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR PANTHER; PTHR45789; FI18025P1; 1.
DR PANTHER; PTHR45789:SF3; TRANSCRIPTION FACTOR SOX-5; 1.
DR Pfam; PF00505; HMG_box; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125}.
SQ SEQUENCE 772 AA; 84954 MW; 0222FCD5E8F5D228 CRC64;
MLTDPDLPQE FERMSSKRPA SPYGEADGEV AMVTSRQKVG EEESDGLPAF HLPLHVSFPN
KPHSEEFQPV SLLTQENCGH RTPTSQHNTM EVDGNKAMSS FAPHNSSTSP LKAEEGGRQS
GESLSSTALG TPERRKGSLA DVVDTLKQRK MEELIKNEPE ETPSIEKLLS KDWKDKLLAM
GSGNFGEIKG TPESLAEKER QLMGMINQLT SLREQLLAAH DEQKKLAASQ IEKQRQQMEL
AKQQQEQIAR QQQQLLQQQH KINLLQQQIQ VQGQLPPLMI PVFPPDQRTL AAAAQQGFLL
PPGFSYKAGC SDPYPVQLIP TTMAAAAAAT PGLGPLQLQQ LYAAQLAAMQ VSPGGKIPGI
SQGNLGAAVS PTSIHTDKST NSPPPKSKDE VAQPLNLSAK PKTSDGKSPT SPTSPHMPTL
RINSGTSSLK SSVPATLASP SARANTIDIL SSITSSGYLN DHDAVTKAIQ EARQMKEQLR
REQQVLDGKV AVVNSLGLNN CRTEKDKTTL ETLTQQLAVK QSEDGKFSHA MMDFNMSGDS
DGSAGVSESR IYRESRGRGS NEPHIKRPMN AFMVWAKDER RKILQAFPDM HNSNISKILG
SRWKAMTNLE KQPYYEEQAR LSKQHLEKYP DYKYKPRPKR TCLVDGKKLR IGEYKAIMRN
RRQEMRQYFN VGQQAQIPIA TAGVVYPGAI AMAGMPSPHL PSEHSSVSSS PEPGMPVIQS
TYGIKGEEPH IKEEMQTDDV NGEIYDEYDE EEDDPDVDYG SDSENHIAGQ AN
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