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Database: UniProt
Entry: Q6A9K7
LinkDB: Q6A9K7
Original site: Q6A9K7 
ID   UVRB_CUTAK              Reviewed;         701 AA.
AC   Q6A9K7;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   13-NOV-2019, entry version 106.
DE   RecName: Full=UvrABC system protein B {ECO:0000255|HAMAP-Rule:MF_00204};
DE            Short=Protein UvrB {ECO:0000255|HAMAP-Rule:MF_00204};
DE   AltName: Full=Excinuclease ABC subunit B {ECO:0000255|HAMAP-Rule:MF_00204};
GN   Name=uvrB {ECO:0000255|HAMAP-Rule:MF_00204};
GN   OrderedLocusNames=PPA0803;
OS   Cutibacterium acnes (strain DSM 16379 / KPA171202) (Propionibacterium
OS   acnes).
OC   Bacteria; Actinobacteria; Propionibacteriales; Propionibacteriaceae;
OC   Cutibacterium.
OX   NCBI_TaxID=267747;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 16379 / KPA171202;
RX   PubMed=15286373; DOI=10.1126/science.1100330;
RA   Brueggemann H., Henne A., Hoster F., Liesegang H., Wiezer A.,
RA   Strittmatter A., Hujer S., Duerre P., Gottschalk G.;
RT   "The complete genome sequence of Propionibacterium acnes, a commensal
RT   of human skin.";
RL   Science 305:671-673(2004).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. A damage recognition complex composed
CC       of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon
CC       binding of the UvrA(2)B(2) complex to a putative damaged site, the
CC       DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP
CC       binding by UvrB and probably causes local melting of the DNA
CC       helix, facilitating insertion of UvrB beta-hairpin between the DNA
CC       strands. Then UvrB probes one DNA strand for the presence of a
CC       lesion. If a lesion is found the UvrA subunits dissociate and the
CC       UvrB-DNA preincision complex is formed. This complex is
CC       subsequently bound by UvrC and the second UvrB is released. If no
CC       lesion is found, the DNA wraps around the other UvrB subunit that
CC       will check the other stand for damage. {ECO:0000255|HAMAP-
CC       Rule:MF_00204}.
CC   -!- SUBUNIT: Forms a heterotetramer with UvrA during the search for
CC       lesions. Interacts with UvrC in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00204}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00204}.
CC   -!- DOMAIN: The beta-hairpin motif is involved in DNA binding.
CC       {ECO:0000255|HAMAP-Rule:MF_00204}.
CC   -!- SIMILARITY: Belongs to the UvrB family. {ECO:0000255|HAMAP-
CC       Rule:MF_00204}.
DR   EMBL; AE017283; AAT82559.1; -; Genomic_DNA.
DR   RefSeq; WP_002518347.1; NC_006085.1.
DR   SMR; Q6A9K7; -.
DR   STRING; 267747.PPA0803; -.
DR   PRIDE; Q6A9K7; -.
DR   EnsemblBacteria; AAT82559; AAT82559; PPA0803.
DR   GeneID; 2932368; -.
DR   KEGG; pac:PPA0803; -.
DR   PATRIC; fig|267747.3.peg.839; -.
DR   eggNOG; ENOG4105CCW; Bacteria.
DR   eggNOG; COG0556; LUCA.
DR   HOGENOM; HOG000073580; -.
DR   KO; K03702; -.
DR   OMA; RYMHSEI; -.
DR   BioCyc; PACN267747:G1G0Y-884-MONOMER; -.
DR   Proteomes; UP000000603; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATPase activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00204; UvrB; 1.
DR   InterPro; IPR006935; Helicase/UvrB_N.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004807; UvrB.
DR   InterPro; IPR041471; UvrB_inter.
DR   InterPro; IPR024759; UvrB_YAD/RRR_dom.
DR   PANTHER; PTHR24029; PTHR24029; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF04851; ResIII; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF12344; UvrB; 1.
DR   Pfam; PF17757; UvrB_inter; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   TIGRFAMs; TIGR00631; uvrb; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS50151; UVR; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA damage; DNA excision;
KW   DNA repair; Excision nuclease; Nucleotide-binding; Reference proteome;
KW   SOS response.
FT   CHAIN         1    701       UvrABC system protein B.
FT                                /FTId=PRO_0000227345.
FT   DOMAIN       35    419       Helicase ATP-binding. {ECO:0000255|HAMAP-
FT                                Rule:MF_00204}.
FT   DOMAIN      438    604       Helicase C-terminal. {ECO:0000255|HAMAP-
FT                                Rule:MF_00204}.
FT   DOMAIN      657    692       UVR. {ECO:0000255|HAMAP-Rule:MF_00204}.
FT   NP_BIND      48     55       ATP. {ECO:0000255|HAMAP-Rule:MF_00204}.
FT   MOTIF       101    124       Beta-hairpin.
SQ   SEQUENCE   701 AA;  79703 MW;  470882103E00B89C CRC64;
     MRPVTDITRR VAPFHVVSEF QPSGDQPQAI AELEKRVNSG EQDVVLLGAT GTGKTATVAW
     LAERLQRPML VMQPNKTLAA QFAQELRTFF PDNAVEYFVS YYDYYQPEAY IPQTDTYIEK
     DSSLNEEVER LRHSATNSLL TRRDVIVVST VSAIYGLGTP QEYVDRMIPL EVGQEWDRDE
     LLRDLVTNQY VRNDISGERG TFRVRGDTLE IFPVYEENAL RVEFFGDEIE ALTTMHPLTG
     EIISEDEQVY VFPATHYVAG PERMERAIAS IQQELEERLA VLERDGKLLE AQRLRMRTTY
     DIEMMQQVGA CAGIENYSRH IDGRAPGSAP NCLLDYFPED FVLVIDESHV TVPQIGGMYE
     GDMSRKRTLV EHGFRLPSAM DNRPLKFDEF TQRIGQTVYL SATPGSYETE RAHGVVEQII
     RPTGLVDPEI IVKPTRGQID DLMGEIRTRV DRGDGVLVTT LTKKMAEDLT DYLMEHGIRT
     RYLHSEIDTL KRIELLKELR MGEFDVLVGI NLLREGLDLP EVSLVAILDA DKEGFLRSER
     SLIQTVGRAA RNVNGQVIMY ADQITDSMQV AIDETNRRRD IQMAYNKEHG IDPQPLRKKI
     GDITEMLARE GADTDELVEK FNYGKGQRGY NSMITDEQRA AQGRRLDVSK MAEEDLGKLI
     VDLTTEMRSA AGELKFEVAA RLRDEIADLK KELRQMVEAN R
//
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