ID Q6AE50_LEIXX Unreviewed; 633 AA.
AC Q6AE50;
DT 13-SEP-2004, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2004, sequence version 1.
DT 27-MAR-2024, entry version 108.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=pkaF {ECO:0000313|EMBL:AAT89346.1};
GN OrderedLocusNames=Lxx15400 {ECO:0000313|EMBL:AAT89346.1};
OS Leifsonia xyli subsp. xyli (strain CTCB07).
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC Leifsonia.
OX NCBI_TaxID=281090 {ECO:0000313|EMBL:AAT89346.1, ECO:0000313|Proteomes:UP000001306};
RN [1] {ECO:0000313|EMBL:AAT89346.1, ECO:0000313|Proteomes:UP000001306}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CTCB07 {ECO:0000313|EMBL:AAT89346.1,
RC ECO:0000313|Proteomes:UP000001306};
RX PubMed=15305603;
RA Monteiro-Vitorello C.B., Camargo L.E.A., Van Sluys M.A., Kitajima J.P.,
RA Truffi D., do Amaral A.M., Harakava R., de Oliveira J.C.F., Wood D.,
RA de Oliveira M.C., Miyaki C.Y., Takita M.A., da Silva A.C.R., Furlan L.R.,
RA Carraro D.M., Camarotte G., Almeida N.F. Jr., Carrer H., Coutinho L.L.,
RA El-Dorry H.A., Ferro M.I.T., Gagliardi P.R., Giglioti E., Goldman M.H.S.,
RA Goldman G.H., Kimura E.T., Ferro E.S., Kuramae E.E., Lemos E.G.M.,
RA Lemos M.V.F., Mauro S.M.Z., Machado M.A., Marino C.L., Menck C.F.,
RA Nunes L.R., Oliveira R.C., Pereira G.G., Siqueira W., de Souza A.A.,
RA Tsai S.M., Zanca A.S., Simpson A.J.G., Brumbley S.M., Setubal J.C.;
RT "The genome sequence of the Gram-positive sugarcane pathogen Leifsonia xyli
RT subsp. xyli.";
RL Mol. Plant Microbe Interact. 17:827-836(2004).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
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DR EMBL; AE016822; AAT89346.1; -; Genomic_DNA.
DR RefSeq; WP_011186336.1; NC_006087.1.
DR AlphaFoldDB; Q6AE50; -.
DR STRING; 281090.Lxx15400; -.
DR KEGG; lxx:Lxx15400; -.
DR eggNOG; COG0515; Bacteria.
DR eggNOG; COG2815; Bacteria.
DR HOGENOM; CLU_000288_135_2_11; -.
DR Proteomes; UP000001306; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd06577; PASTA_pknB; 4.
DR CDD; cd14014; STKc_PknB_like; 1.
DR Gene3D; 3.30.10.20; -; 4.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR005543; PASTA_dom.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR NCBIfam; NF033483; PknB_PASTA_kin; 1.
DR PANTHER; PTHR45832:SF24; PROTEIN KINASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45832; SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED; 1.
DR Pfam; PF03793; PASTA; 3.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00740; PASTA; 4.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51178; PASTA; 3.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:AAT89346.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001306};
KW Transferase {ECO:0000313|EMBL:AAT89346.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 337..358
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 18..274
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 360..427
FT /note="PASTA"
FT /evidence="ECO:0000259|PROSITE:PS51178"
FT DOMAIN 499..565
FT /note="PASTA"
FT /evidence="ECO:0000259|PROSITE:PS51178"
FT DOMAIN 566..632
FT /note="PASTA"
FT /evidence="ECO:0000259|PROSITE:PS51178"
SQ SEQUENCE 633 AA; 66380 MW; 70084F63890682A5 CRC64;
MTTSQTDPLI GRLIDGRYQV RSRIARGGMA TVYLATDLRL ERRVAIKVMH GHLADDTTFK
NRFVQEARSA ARLAHPNVVN VFDQGQDSDM AYLVMEYLPG ITLRDLLKDY GKLTPEQTID
IMEAVLSGLV AAHKAGIVHR DLKPENVLLA DDGRIKIGDF GLARAASANT ATGQALLGTI
AYLSPELVTR GVADARSDIY ALGIMMYEML TGEQPFQGEQ PMQIAYQHAN DAVPTPSGKN
PAVPAELDDL VQWATEKDPD RRPKDARELF DRLVEAEKSL RGEAALQLTM VLPPAFEAAE
GETQIINPAI RQQVAASAPS ATDRLSAASA RRRAKGWWLF ALVILLAGLA GGTGWYFGAG
PGSLVTVPNV VSKTPAAAAA KLTELGFRTK QAQEYSVTVP AGQVSSTVPV AETPAGRGST
VTLRVSQGPK PVTIPPLAGH PLDTAKAAIT GVGAKVGTIA EQFDGKVHSG TVISATKTSD
GGDISGGGPY FEAASVDLVV SVGPVPDVAG KSVESATALL HKAGLVVVAG PESYSETIAK
GDVISAQPQA AVVRPGDTVA LKTSKGPEPV PVPDVVGQTW DKAKKTLTEA GFALKYSTAA
DLLPGAFVVS KISPDAGTQA DKGSTVTVNF ASF
//
