GenomeNet

Database: UniProt
Entry: Q6BL34
LinkDB: Q6BL34
Original site: Q6BL34 
ID   DBP10_DEBHA             Reviewed;         932 AA.
AC   Q6BL34;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   16-OCT-2019, entry version 97.
DE   RecName: Full=ATP-dependent RNA helicase DBP10;
DE            EC=3.6.4.13;
GN   Name=DBP10; OrderedLocusNames=DEHA2F16720g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC
OS   0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S.,
RA   Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E.,
RA   Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V.,
RA   Barnay S., Blanchin S., Beckerich J.-M., Beyne E., Bleykasten C.,
RA   Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A.,
RA   Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A.,
RA   Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R.,
RA   Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H.,
RA   Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O.,
RA   Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A.,
RA   Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B.,
RA   Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A.,
RA   Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA   Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: ATP-binding RNA helicase involved in the biogenesis of
CC       60S ribosomal subunits and is required for the normal formation of
CC       25S and 5.8S rRNAs. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD
CC       box family of RNA helicases and controls ATP binding and
CC       hydrolysis.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX54/DBP10
CC       subfamily. {ECO:0000305}.
DR   EMBL; CR382138; CAG89469.2; -; Genomic_DNA.
DR   RefSeq; XP_461087.2; XM_461087.1.
DR   SMR; Q6BL34; -.
DR   STRING; 4959.XP_461087.2; -.
DR   PRIDE; Q6BL34; -.
DR   EnsemblFungi; CAG89469; CAG89469; DEHA2F16720g.
DR   GeneID; 2903098; -.
DR   KEGG; dha:DEHA2F16720g; -.
DR   HOGENOM; HOG000246455; -.
DR   InParanoid; Q6BL34; -.
DR   KO; K14808; -.
DR   OMA; CVEMDLK; -.
DR   OrthoDB; 268859at2759; -.
DR   Proteomes; UP000000599; Chromosome F.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:EnsemblFungi.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0042802; F:identical protein binding; IEA:EnsemblFungi.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:1902626; P:assembly of large subunit precursor of preribosome; IEA:EnsemblFungi.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   InterPro; IPR012541; DBP10_C.
DR   InterPro; IPR033517; DDX54/DBP10.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   PANTHER; PTHR24031:SF292; PTHR24031:SF292; 1.
DR   Pfam; PF08147; DBP10CT; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM01123; DBP10CT; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Helicase; Hydrolase;
KW   Nucleotide-binding; Nucleus; Reference proteome; Ribosome biogenesis;
KW   RNA-binding; rRNA processing.
FT   CHAIN         1    932       ATP-dependent RNA helicase DBP10.
FT                                /FTId=PRO_0000232314.
FT   DOMAIN      128    300       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      369    529       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND     141    148       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   MOTIF        97    125       Q motif.
FT   MOTIF       248    251       DEAD box.
FT   COMPBIAS    858    932       Lys-rich.
SQ   SEQUENCE   932 AA;  106230 MW;  6036FC618110DDD1 CRC64;
     MSDEEDYDIA GTLALAGSDS EPESDLNSDN EEVQDEIVSD EDDTKHKPNK KQKLEKGKSK
     QTFPSLELSD DEAENESKDM ASYFVANNPQ AKKAKNGSFP SFGFSKFLLT NISKKGFKQP
     TPIQRKTIPL IMENRDVVGM ARTGSGKTAA FTLPLVEKLK SHSPRVGVRA IILSPSRELA
     SQTFKQVKEF SKGTDLRSIV LIGGDSLEEQ FSSMMTNPDV IVATPGRFLH LKVEMELELK
     TVEYIVFDEA DRLFEMGFAE QLNELIAALP SSRQSLLFSA TLPRSLIDFA KAGLTNPVLV
     RLDAETKISD QLQMAFFSIK NNEREASLLY VLQEVIKLPL ASPEEVKRYS DMEKRDNGSE
     DEAEDENNNK KKRFKFKKER LPPANMLPSK HSTIIFVPTK HHVEYVTTLL KDAGYLVSYI
     YGTLDQHARK QQLYQFRIGM TSLLVVTDVA ARGIDIPILA NVVNYTLPGS SKIFIHRVGR
     TARAGNSGWA YSIVNEKELP YLLDLELFLG RKVLLTSMHE KKCEMLKTKQ SSNYVEPKVS
     YTDRLVLGSI PRVDIETFQE LYENILRNHY ELSVVKGVAT KGEKLYYRTR QSASQESLKR
     SKEILSTGNW DDQHLLFGPN LEKEKEKFLT QLLNRKSKET VFEFNKKGND RDEDSLVEFM
     HKRRKQIAPI QRRAKEKREL LEKERMAGLT HGIENEILKN DGEIGYSGIT IEADEEELQD
     AFEDADELIE KKKIEKKKSF RDPQYFLSHY APAAVIQDQQ LSLSSSFAND AAKATFDLDN
     DEKLNANKQV MQWDRKKGNY VNAHSTDKKF IIGESGQKIP ATYRSGRFDD WKKQRNLKPT
     KTGAMEANAT NGNDRRFKHK KVASPKLPDK FRDDYHKQKE KVKKAVDSGL KVKGYNKPGQ
     KQELRSTEDI RKAREAKDKK KQKNARPSRK RK
//
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