ID MCH1_DEBHA Reviewed; 486 AA.
AC Q6BN11;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 2.
DT 24-JAN-2024, entry version 89.
DE RecName: Full=Probable transporter MCH1;
GN Name=MCH1; OrderedLocusNames=DEHA2F01078g;
OS Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX NCBI_TaxID=284592;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Probable transporter. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CR382138; CAG88713.2; -; Genomic_DNA.
DR RefSeq; XP_460409.2; XM_460409.1.
DR AlphaFoldDB; Q6BN11; -.
DR SMR; Q6BN11; -.
DR GlyCosmos; Q6BN11; 3 sites, No reported glycans.
DR GeneID; 2903809; -.
DR KEGG; dha:DEHA2F01078g; -.
DR VEuPathDB; FungiDB:DEHA2F01078g; -.
DR eggNOG; ENOG502QTNE; Eukaryota.
DR HOGENOM; CLU_012596_3_0_1; -.
DR InParanoid; Q6BN11; -.
DR OMA; PTMWWLA; -.
DR OrthoDB; 1047262at2759; -.
DR Proteomes; UP000000599; Chromosome F.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR CDD; cd17354; MFS_Mch1p_like; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR21576:SF45; TRANSPORTER MCH1-RELATED; 1.
DR PANTHER; PTHR21576; UNCHARACTERIZED NODULIN-LIKE PROTEIN; 1.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE 3: Inferred from homology;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport; Vacuole.
FT CHAIN 1..486
FT /note="Probable transporter MCH1"
FT /id="PRO_0000084870"
FT TRANSMEM 31..51
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 69..89
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 91..111
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 132..152
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 164..184
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 204..224
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 280..300
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 327..348
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 357..377
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 395..415
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 417..437
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 458..478
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 236..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 243..260
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 322
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 390
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 457
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 486 AA; 54351 MW; 5BD91B6CB8D0BFCD CRC64;
MLKHKTFINR ISHSIKHYLS FHVSIANLKK ISFFISLFSC LTSGSIMLFS LFSSSLHELY
GINYLHINFI ASLSAIGMYL CLPVLGYLAD CYGPSLLSLI SIWFFVPSYF VNSQVIKSLE
YNNVMKIHLY AFGICFFFIG LATSSLYFSS LLTCAKIYPE HKGLAISLPV TCYGLSTLLG
SQLMKLSYFK QYNGFLNLHK VFNFFGVLYL VMGILNFVSS SVVSMESEII FTNEDEMEEA
DEESPLMTSR SRHSHHSCED DDNLIPERSI IEPLKHQERF INFLKDKSAW LLLASLILNI
GPMESFQNNL GSIIINSNSE SNLSDQVSIM AASSTVTRLA MGGLSDYLSS SKRKFPICRV
NLLIINLAIG IVGQFMVTRS TRFSIVSILN GSSYGGLFTI YPTIVASIWG IDMMGSTWGS
FMIAPAIGSI GFSIFYGNEV DNKCGVDYSS CLQHYFNLTA VGLSVSLILI IIVWKGIWAK
RGYRVF
//
