GenomeNet

Database: UniProt
Entry: Q6BV58
LinkDB: Q6BV58
Original site: Q6BV58 
ID   MAK5_DEBHA              Reviewed;         790 AA.
AC   Q6BV58;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   31-JUL-2019, entry version 90.
DE   RecName: Full=ATP-dependent RNA helicase MAK5;
DE            EC=3.6.4.13;
GN   Name=MAK5; OrderedLocusNames=DEHA2C05170g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC
OS   0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S.,
RA   Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E.,
RA   Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V.,
RA   Barnay S., Blanchin S., Beckerich J.-M., Beyne E., Bleykasten C.,
RA   Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A.,
RA   Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A.,
RA   Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R.,
RA   Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H.,
RA   Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O.,
RA   Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A.,
RA   Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B.,
RA   Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A.,
RA   Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA   Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: ATP-binding RNA helicase involved in the biogenesis of
CC       60S ribosomal subunits and is required for the normal formation of
CC       25S and 5.8S rRNAs. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD
CC       box family of RNA helicases and controls ATP binding and
CC       hydrolysis.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX24/MAK5
CC       subfamily. {ECO:0000305}.
DR   EMBL; CR382135; CAG85962.1; -; Genomic_DNA.
DR   RefSeq; XP_457911.1; XM_457911.1.
DR   SMR; Q6BV58; -.
DR   STRING; 4959.XP_457911.1; -.
DR   PRIDE; Q6BV58; -.
DR   EnsemblFungi; CAG85962; CAG85962; DEHA2C05170g.
DR   GeneID; 2900812; -.
DR   KEGG; dha:DEHA2C05170g; -.
DR   HOGENOM; HOG000290702; -.
DR   InParanoid; Q6BV58; -.
DR   KO; K14805; -.
DR   OMA; HANMIQK; -.
DR   OrthoDB; 973872at2759; -.
DR   Proteomes; UP000000599; Chromosome C.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Helicase; Hydrolase;
KW   Nucleotide-binding; Nucleus; Reference proteome; Ribosome biogenesis;
KW   RNA-binding; rRNA processing.
FT   CHAIN         1    790       ATP-dependent RNA helicase MAK5.
FT                                /FTId=PRO_0000232234.
FT   DOMAIN      230    427       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      483    642       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND     243    250       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   MOTIF       199    227       Q motif.
FT   MOTIF       364    367       DEAD box.
FT   COMPBIAS     47    151       Asp-rich.
SQ   SEQUENCE   790 AA;  89112 MW;  B69D00860CAE4879 CRC64;
     MKVSKDKSKK GVKSKPKTSR KPLSLKQKLQ RESKIVKVDN LNWKAVDIPD NLDDYQGFYG
     LEEIDGVDVK VTGGNVEFVV KDNSKVKDSD NEEDDDDVHD DDDNQDDGDD DQDDDDVDIE
     DDEDEIIEGD NEDDFKGFDD DNAINEDDQM DIESAKTEKK SKKEVKPKNE KVAKKDSILE
     SAFKNVDLTL PDDNEVNLPY WDDLSLSSFT LNGLSALEYE KPTAIQKRTI PLAIEGKDVI
     GKAITGSGKT LAYGIPILER HLQKMAKANQ SKKVINPPTG IIFAPTRELA HQVVDHLNRI
     AKFTPLSQHG IVSITGGLSI QKQERLLSHG PGIVVATPGR FLELLQKDMA LVQRLSCTDI
     VVLDEADRLL QDGHFDEFVK ILELFGKHRP RDNKELEWKW QTLVFSATFS RDLFGKLDKH
     LKSNKNKEEM GSSLIDNDEI LQLLNDKLKF KDSKPTLVDA NPKEMVAGQI TEALVECGPT
     ERDLYLYYFL LLYPGSTLVF ANSIDSVKRL APFLNNLKVP TFSIHSSMIQ KQRLRTLERF
     KEASSKNSTA VLIASDVAAR GLDIPNIDHV AHYHLPRSAD VYIHRSGRTG RAGKEGVSIM
     FCSPQESSGP LRKLRKLVAN NTKKRTRLNV HNDVKLLPLE MDLVSQIKPR VTLASKLADA
     ERSSSSTRKE DNWVHEAAEE LGIDNLSDID NFEDDFIKRQ RKRKENKALT KDEARSLRLE
     LNDLLSKQIR KNSRRSYLTS GLQNLAHQMV TGNTHKDVLG HASVNALDDL RTKKAIKKKQ
     IKTKKVKDKK
//
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