ID Q6BZ59_DEBHA Unreviewed; 776 AA.
AC Q6BZ59;
DT 16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT 04-NOV-2008, sequence version 2.
DT 27-MAR-2024, entry version 118.
DE SubName: Full=DEHA2A04334p {ECO:0000313|EMBL:CAG84465.2};
GN OrderedLocusNames=DEHA2A04334g {ECO:0000313|EMBL:CAG84465.2};
OS Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX NCBI_TaxID=284592 {ECO:0000313|EMBL:CAG84465.2, ECO:0000313|Proteomes:UP000000599};
RN [1] {ECO:0000313|EMBL:CAG84465.2, ECO:0000313|Proteomes:UP000000599}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC
RC 2968 {ECO:0000313|Proteomes:UP000000599};
RX PubMed=15229592; DOI=10.1038/nature02579;
RG Genolevures;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.F., Straub M.L.,
RA Suleau A., Swennene D., Tekaia F., Wesolowski-Louvel M., Westhof E.,
RA Wirth B., Zeniou-Meyer M., Zivanovic I., Bolotin-Fukuhara M., Thierry A.,
RA Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA Wincker P., Souciet J.L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- SIMILARITY: Belongs to the exosome component 10/RRP6 family.
CC {ECO:0000256|ARBA:ARBA00043957}.
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DR EMBL; CR382133; CAG84465.2; -; Genomic_DNA.
DR RefSeq; XP_456510.2; XM_456510.1.
DR AlphaFoldDB; Q6BZ59; -.
DR STRING; 284592.Q6BZ59; -.
DR GeneID; 2899845; -.
DR KEGG; dha:DEHA2A04334g; -.
DR VEuPathDB; FungiDB:DEHA2A04334g; -.
DR eggNOG; KOG2206; Eukaryota.
DR HOGENOM; CLU_010129_3_2_1; -.
DR InParanoid; Q6BZ59; -.
DR OMA; TMDIIWL; -.
DR OrthoDB; 2880475at2759; -.
DR Proteomes; UP000000599; Chromosome A.
DR GO; GO:0000176; C:nuclear exosome (RNase complex); IEA:InterPro.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0000175; F:3'-5'-RNA exonuclease activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:InterPro.
DR CDD; cd06147; Rrp6p_like_exo; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR InterPro; IPR012588; Exosome-assoc_fac_Rrp6_N.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR045092; Rrp6-like.
DR InterPro; IPR049559; Rrp6p-like_exo.
DR PANTHER; PTHR12124:SF47; EXOSOME COMPONENT 10; 1.
DR PANTHER; PTHR12124; POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED; 1.
DR Pfam; PF01612; DNA_pol_A_exo1; 1.
DR Pfam; PF00570; HRDC; 1.
DR Pfam; PF08066; PMC2NT; 1.
DR SMART; SM00474; 35EXOc; 1.
DR SMART; SM00341; HRDC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50967; HRDC; 1.
PE 3: Inferred from homology;
KW Exosome {ECO:0000256|ARBA:ARBA00022835};
KW Reference proteome {ECO:0000313|Proteomes:UP000000599};
KW rRNA processing {ECO:0000256|ARBA:ARBA00022552}.
FT DOMAIN 459..540
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
FT REGION 652..776
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 656..712
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 714..730
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 731..760
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 776 AA; 88796 MW; C0698E16751F2F64 CRC64;
MSDIPSVSTF DDILPNVVQT VRNSSSLAAQ DINFYKSLDS DLSKKIDESA KSLLDISNKL
IHCSFDDVKD VPFGKDNISS HANWNPIANV LDNIFEKIDI AFDQAQNANS RKANAEAKGF
TYLEDSNTIN DSSNKHQGKR MVKPQINFRN KVDNSETHPF KPKISSKPNE LKSFDESTKL
IVPMKQEESN DIDPEYYVQP YEFEIDSQPY PDSILTKKEP IPSKPWSKTS AIWVDSVDVL
NEMISLLSEQ SEIAIDLEHH DYRSYYGIVC LMQISSRDQD WIIDTLKLRD DLESLNKVFT
NPDIVKVFHG AFMDIIWLQR DLGLYIVSLF DTYHASKKLG FPKFSLAYLL ETFANFKTSK
KYQLADWRIR PLSPPMLAYA RSDTHFLLNI YDQLRNKLID AGANRLQEVL YESRQVAKRR
FEYTKFRPLS TSGGKVSCPV MANNPKEPFS SILLQYNVPY HKKPLIEALY NWRDALAKRD
DESVRYIMSN QLLVSLSSLS QPVDVQKVLG VSNYISDYVR QNAKDLANLI ENTLKSMADS
DWELVDKWND ISKAADNDKM NISDDDLDKI ISRSKAFEDI YAHNKNVLFF DGTELLSNKS
ALFSELLNNN NDSFSVEYDV EKNKVINHTS GDYKDRLDYA SKNLQPNPII ISPEISHRNE
QHDEPKKPYI DETHAGKSST VLKDEEMDPN EVITLRKTQK QKTPKAEIKQ TAENDAFDYN
NANKILLDSS IRNSSRKEKP KKRSFDPYGK DAEGPKGAKK ARRPNTGKTS TFSTKK
//
