GenomeNet

Database: UniProt
Entry: Q6C193
LinkDB: Q6C193
Original site: Q6C193 
ID   SPB4_YARLI              Reviewed;         626 AA.
AC   Q6C193;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   16-OCT-2019, entry version 96.
DE   RecName: Full=ATP-dependent rRNA helicase SPB4;
DE            EC=3.6.4.-;
GN   Name=SPB4; OrderedLocusNames=YALI0F18238g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida
OS   lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S.,
RA   Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E.,
RA   Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V.,
RA   Barnay S., Blanchin S., Beckerich J.-M., Beyne E., Bleykasten C.,
RA   Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A.,
RA   Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A.,
RA   Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R.,
RA   Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H.,
RA   Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O.,
RA   Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A.,
RA   Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B.,
RA   Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A.,
RA   Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA   Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: ATP-binding RNA helicase involved in the biogenesis of
CC       60S ribosomal subunits. Required for the normal formation of 18S
CC       rRNA through the processing of pre-rRNAs at sites A0, A1 and A2,
CC       and the normal formation of 25S and 5.8S rRNAs through the
CC       processing of pre-rRNAs at sites C1 and C2 (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD
CC       box family of RNA helicases and controls ATP binding and
CC       hydrolysis.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX55/SPB4
CC       subfamily. {ECO:0000305}.
DR   EMBL; CR382132; CAG78378.1; -; Genomic_DNA.
DR   RefSeq; XP_505569.1; XM_505569.1.
DR   SMR; Q6C193; -.
DR   PRIDE; Q6C193; -.
DR   EnsemblFungi; CAG78378; CAG78378; YALI0_F18238g.
DR   GeneID; 2908671; -.
DR   KEGG; yli:YALI0F18238g; -.
DR   HOGENOM; HOG000268803; -.
DR   InParanoid; Q6C193; -.
DR   KO; K14809; -.
DR   OMA; RRHKETP; -.
DR   Proteomes; UP000001300; Chromosome F.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR025313; DUF4217.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF13959; DUF4217; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM01178; DUF4217; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Coiled coil; Complete proteome; Helicase; Hydrolase;
KW   Nucleotide-binding; Nucleus; Reference proteome; Ribosome biogenesis;
KW   RNA-binding; rRNA processing.
FT   CHAIN         1    626       ATP-dependent rRNA helicase SPB4.
FT                                /FTId=PRO_0000232334.
FT   DOMAIN       34    239       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      273    437       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND      47     54       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   COILED      523    604       {ECO:0000255}.
FT   MOTIF         3     31       Q motif.
FT   MOTIF       187    190       DEAD box.
SQ   SEQUENCE   626 AA;  71091 MW;  629C7DA23D26AEC4 CRC64;
     MSTDWKDLPV APWLIDTMEQ FGFTDMTPVQ ASVIPMFAGN KDVIVEAVTG SGKTIAFLVP
     LIQRMLNLLK EGPAVSGRVY SVVVSPTREL ARQTYEVLQS ILEMGCPEAD ASDKITLEKK
     KKGKAAPTMP KKIRGQLIMG GDLPSHMDLK NFLRDKPQII VATPGRLLEL LRAPQIKTSA
     FDSLVLDEAD RLLDLGFGRD ITSIINILPK QRRTGLFSAT ITDAIQNLVK IGLRNPVKIV
     VKVGGKKEQK TPLSLGLSYV VLEPREKLAY ALNLLSIYPY RKAIVYLPTC AAVTYYQQMF
     SHLNEGREEP YEIYGLHGKL PSSTRIKILN KYQKTGAQAI LMTTDIAARG LDIPEVDLVV
     QLDPPSDADT FQHRCGRAGR AGRQGQAIVL LHKGREEEYV DLMRVRKVKL RPYTGPGSEL
     EGEKLDQEAT ELYTKLRKWV LEDRQRHDQA LLSFVSFVRF YSKHVAQSIF RIQSLDLPGL
     AASYGLLRLP KMPELRTKDN ERPENTWLGE VIDFDTYSYK NPAKEEARLK ELEAHKEAMK
     NKVKIHKTKN DVQKANRAWS STLQKKEEKS ERHQKKQTRI NEKIKRDFEE AKDLKQEESK
     EVVNDWKDMV KKSKKRKVDL PTFDDL
//
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