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Database: UniProt
Entry: Q6C3X7
LinkDB: Q6C3X7
Original site: Q6C3X7 
ID   DBP5_YARLI              Reviewed;         488 AA.
AC   Q6C3X7;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   11-DEC-2019, entry version 103.
DE   RecName: Full=ATP-dependent RNA helicase DBP5;
DE            EC=3.6.4.13;
GN   Name=DBP5; OrderedLocusNames=YALI0E31427g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: ATP-dependent RNA helicase associated with the nuclear pore
CC       complex and essential for mRNA export from the nucleus. May participate
CC       in a terminal step of mRNA export through the removal of proteins that
CC       accompany mRNA through the nucleopore complex. May also be involved in
CC       early transcription (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBUNIT: Associates with the nuclear pore complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus, nuclear pore
CC       complex. Nucleus membrane {ECO:0000250}; Peripheral membrane protein
CC       {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Nuclear pore
CC       complex cytoplasmic fibrils. {ECO:0000250}.
CC   -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD box
CC       family of RNA helicases and controls ATP binding and hydrolysis.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX19/DBP5
CC       subfamily. {ECO:0000305}.
DR   EMBL; CR382131; CAG80239.1; -; Genomic_DNA.
DR   RefSeq; XP_504635.1; XM_504635.1.
DR   SMR; Q6C3X7; -.
DR   PRIDE; Q6C3X7; -.
DR   EnsemblFungi; CAG80239; CAG80239; YALI0_E31427g.
DR   GeneID; 2911469; -.
DR   KEGG; yli:YALI0E31427g; -.
DR   HOGENOM; HOG000268797; -.
DR   InParanoid; Q6C3X7; -.
DR   KO; K18655; -.
DR   OMA; CKLYGLM; -.
DR   Proteomes; UP000001300; Chromosome E.
DR   GO; GO:0010494; C:cytoplasmic stress granule; IBA:GO_Central.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005643; C:nuclear pore; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IBA:GO_Central.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; Helicase; Hydrolase; Membrane; mRNA transport;
KW   Nuclear pore complex; Nucleotide-binding; Nucleus; Protein transport;
KW   Reference proteome; RNA-binding; Translocation; Transport.
FT   CHAIN           1..488
FT                   /note="ATP-dependent RNA helicase DBP5"
FT                   /id="PRO_0000232228"
FT   DOMAIN          132..298
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   DOMAIN          326..477
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT   NP_BIND         145..152
FT                   /note="ATP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   MOTIF           99..127
FT                   /note="Q motif"
FT   MOTIF           246..249
FT                   /note="DEAD box"
SQ   SEQUENCE   488 AA;  54389 MW;  54BD916D85DE2A99 CRC64;
     MSDQVSDMLE KLELQKEKNQ AAATEAKVEE VKEDDKKDVK EELNEDDKKV AKEDDKKEDA
     KEESKEDAEE NNLIQTEYEV RVKLADLQAD PNSPLYSAKR FEDLGLDENL LKGLYAMKFN
     KPSKIQEKAL PLLLSDPPHN MIGQSQSGTG KTGAFSLTML SRVDPNLKAV QCICLAPSRE
     LARQTLDVVD EMKKFTDITT HLIVPESTER GQKVTSQILV GTPGSVAGLL QKKQIDAKHV
     KVFVLDEADN MVDSSMGSTC ARIKKYLPSS TQVVLFSATF PESVLDLAGK MCPNPNEIRL
     KANELNVDAI TQLYMDCEDG EEKFKMLEEL YSMLTIASSV IFVAQRSTAN ALYQRMSKNG
     HKVSLLHSDL SVDERDRLMD DFRFGRSKVL ISTNVIARGI DIATVSMVVN YDLPTDKNGK
     PDPETYLHRI GRTGRFGRSG VSISFVHDEA SFEVLDSIQQ SLGMTLTQVP TDDIDEVEEI
     IKKAIKGK
//
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