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Database: UniProt
Entry: Q6C519
LinkDB: Q6C519
Original site: Q6C519 
ID   SET9_YARLI              Reviewed;         866 AA.
AC   Q6C519;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   10-APR-2019, entry version 78.
DE   RecName: Full=Histone-lysine N-methyltransferase SET9;
DE            EC=2.1.1.43;
DE   AltName: Full=SET domain protein 9;
GN   Name=SET9; OrderedLocusNames=YALI0E21802g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida
OS   lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S.,
RA   Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E.,
RA   Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V.,
RA   Barnay S., Blanchin S., Beckerich J.-M., Beyne E., Bleykasten C.,
RA   Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A.,
RA   Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A.,
RA   Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R.,
RA   Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H.,
RA   Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O.,
RA   Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A.,
RA   Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B.,
RA   Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A.,
RA   Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA   Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Histone methyltransferase that specifically methylates
CC       'Lys-20' of histone H4. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) +
CC         N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:10024, Rhea:RHEA-COMP:9845, Rhea:RHEA-COMP:9846,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.43;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU00900};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding
CC       methyltransferase superfamily. Histone-lysine methyltransferase
CC       family. Suvar4-20 subfamily. {ECO:0000255|PROSITE-
CC       ProRule:PRU00900}.
DR   EMBL; CR382131; CAG79838.1; -; Genomic_DNA.
DR   RefSeq; XP_504243.1; XM_504243.1.
DR   ProteinModelPortal; Q6C519; -.
DR   SMR; Q6C519; -.
DR   EnsemblFungi; CAG79838; CAG79838; YALI0_E21802g.
DR   GeneID; 2911957; -.
DR   KEGG; yli:YALI0E21802g; -.
DR   InParanoid; Q6C519; -.
DR   KO; K11429; -.
DR   Proteomes; UP000001300; Chromosome E.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042799; F:histone methyltransferase activity (H4-K20 specific); IEA:InterPro.
DR   InterPro; IPR025783; Hist-Lys_N-MeTrfase_SET9.
DR   InterPro; IPR001214; SET_dom.
DR   Pfam; PF00856; SET; 1.
DR   PROSITE; PS51567; SAM_MT43_SUVAR420_1; 1.
DR   PROSITE; PS50280; SET; 1.
PE   3: Inferred from homology;
KW   Chromatin regulator; Chromosome; Complete proteome; Methyltransferase;
KW   Nucleus; Reference proteome; S-adenosyl-L-methionine; Transferase.
FT   CHAIN         1    866       Histone-lysine N-methyltransferase SET9.
FT                                /FTId=PRO_0000281808.
FT   DOMAIN      111    223       SET. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00190}.
SQ   SEQUENCE   866 AA;  96798 MW;  D251BA712D3BAA24 CRC64;
     MITVTPGELA TIDDALTDLL LERVFYWAEV RKASVHYKPL RGISDRHIHD LVRSIAACET
     GAAANLAVKK ATNAFLELKE VRGYRGRLSP LAYEEFQRHT VRYLTIYKAS CGFEINVSMR
     YKCRSNRGES CVISRVRYNR GDEIVGLSGC LAKMTKDEEL ALANDFSVLH SSRRGGNCLM
     LGPARFVNHD CSANARFVPV PSGMVIQAVK PINVGDEITV KYAENYFGRR NKECLCQTCE
     ENSRGLYGSP QESSEEESDD DMDELTKIEL QRRKKRQEQR EGGTPELREG GRGSSESSRE
     TSEEAIEIST SKNWPLIPKI ESHTADSTPL PVPVGEVSEA TVTEVSTVVP AQEAIPVNES
     TTALSQSSNE FQDPTIDPIL NGASAEIRFP SLPSPDTTTS PESQVPPFIQ PKSARRNHHY
     LGMHNTDERV RFNDRLSVLD ERGGSEDMES CLVSGSESRD DSTAMSRDEE SSRDDGDGSR
     SKRSKRHVRA QRKNSGSWSF SQEDLSFDRL CKAAREQAYD PSRYALTGVY GFSVSGATQT
     CVSCCSVYNL TDGPKTLGHF CPRCHRHAAI HSFAWPYTNH KHALPLCLLM MRPPKKLEDE
     DWGLSKPQVA QQFGAKNRKI FEEDGSLVQK KRKSLAWSWE YTKEEPAQEI TSMRIEDMSP
     KELKKWSQAG RQTRSGRVSM LPEKPKRSRK SAPEPVEMRD NVAQLSREER AWKRARRGTV
     GHEKVEVNTP TVETPSTGTP KVKKLHWKQK LAMERRQKEA EAAEVAETRV ADGVDASTPS
     PAGSTPTPRG RGRPRKSSRE EEIPPEKTPE AKRPSPAATK TPSMSPKVKK EPLSMSFSMS
     PTSRSGRVRN PTEKALQLME QGEYVI
//
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