ID HIR1_YARLI Reviewed; 1058 AA.
AC Q6C553;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2007, sequence version 2.
DT 24-JAN-2024, entry version 124.
DE RecName: Full=Protein HIR1;
GN Name=HIR1; OrderedLocusNames=YALI0E20933g;
OS Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Dipodascaceae; Yarrowia.
OX NCBI_TaxID=284591;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CLIB 122 / E 150;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Required for replication-independent chromatin assembly and
CC for the periodic repression of histone gene transcription during the
CC cell cycle. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat HIR1 family. {ECO:0000305}.
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DR EMBL; CR382131; CAG79804.2; -; Genomic_DNA.
DR RefSeq; XP_504209.2; XM_504209.2.
DR AlphaFoldDB; Q6C553; -.
DR SMR; Q6C553; -.
DR STRING; 284591.Q6C553; -.
DR EnsemblFungi; CAG79804; CAG79804; YALI0_E20933g.
DR GeneID; 2911845; -.
DR KEGG; yli:YALI0E20933g; -.
DR VEuPathDB; FungiDB:YALI0_E20933g; -.
DR HOGENOM; CLU_004372_3_0_1; -.
DR InParanoid; Q6C553; -.
DR OMA; RGSWDGD; -.
DR OrthoDB; 5478541at2759; -.
DR Proteomes; UP000001300; Chromosome E.
DR GO; GO:0000417; C:HIR complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006338; P:chromatin remodeling; IBA:GO_Central.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR031120; HIR1-like.
DR InterPro; IPR011494; HIRA-like_C.
DR InterPro; IPR019015; HIRA_B_motif.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13831; MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS; 1.
DR PANTHER; PTHR13831:SF0; PROTEIN HIRA; 1.
DR Pfam; PF07569; Hira; 1.
DR Pfam; PF09453; HIRA_B; 1.
DR Pfam; PF00400; WD40; 5.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; WD40 repeat-like; 2.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Chromatin regulator; Nucleus; Reference proteome; Repeat; Repressor;
KW Transcription; Transcription regulation; WD repeat.
FT CHAIN 1..1058
FT /note="Protein HIR1"
FT /id="PRO_0000286417"
FT REPEAT 15..54
FT /note="WD 1"
FT REPEAT 82..121
FT /note="WD 2"
FT REPEAT 142..181
FT /note="WD 3"
FT REPEAT 184..223
FT /note="WD 4"
FT REPEAT 239..282
FT /note="WD 5"
FT REPEAT 319..364
FT /note="WD 6"
FT REPEAT 368..409
FT /note="WD 7"
FT REGION 49..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 307..327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 500..536
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 591..610
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 651..696
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1023..1058
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..69
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 500..515
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 663..696
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1058 AA; 114207 MW; 55E550286125C4F2 CRC64;
MYIVKPSWLC HSDDQKKFEV YSVTVSPDNQ RVATGGQDGK VRIWSAQSIR DSAKGDNESS
DTPSNLSGAP APGAKQLCSM ATHNGAVTVV RFSPDGRYLA TGSDDRVVLV WERDSTKVPR
KEFGSSGEAD TESWIVRKRL AAHDNDIQDL AWAPDSSILV TVGLDSGVIV WSGTTFEKIQ
RLDAHNSHVK GITFDPANKF FATASDDRTV QIFRYNRASA TDVTFSTEAT ITSPFKQSPL
STYFRRCSWS PDGNHIAAAN ATNGPVSVVA IINRGTWDSD ISLIGHEAPC EVAAFCPRIF
ARTKEAAEKK DKKSSSEKDK ESDVIDVDAE PKVPESVPIT VIASAGQDKT LTIWNTSNPR
PVVVCHDMAL KTITDLAWSQ DGMSLFATSL DGSISYVQFE EGELGYVVSM EENESRLTRY
GGGKEAAQIP ESVEQLVLEE KVEAKEVKDS EKRMEELMGA AGAGSKAIAS GATVIPSPAS
TVAAAAAAPV TTTARATTPL TAATSNPSTP AKPAKQKVTI TKDGRKRVAP QLLTTTSSSV
QGTLPAATTS SAAVPVASAT AETIPVNDFS KPSYALPKGG VSTLVIGSKR RSDDLEDGSN
GIQTALKKTR PDDDVPEYIA PVVVSPATTT SQVRLGAPKV RNLLMRSMTV RDAEKPRMAN
ESVSLANGEN TSSSSAPHSF NFEVRNGSGN DQTPTKVSVT RNSQVVFVDF VPYYVHLIAG
NGCYFWATSA EDGSIVVYSP NGRRMLPPLV TGAPLSFLES QNEYLLAISS VGMLYLWNVV
DKKAVFPPVS LAPILDSGSR YEDGGVLRGP HVTQCGVTGS GRVIITLSTG CGYTYDEGLR
SWCRLSEPWW ATGSQYWSAT QLLGDESAKS RWVLAVEERT AEEAQRRAGG RGRYLKQLTR
ATLNREGYEG MEGVVSIAHL ENRIAAAEML ESKHELRTFI IMYARRIAEE GLRSRVDELC
RELLGPGKSQ DSTWSPTVCG LDKHELLKEV VLKIGKYRES QRVAVVYGQA IGLLEDEVLG
VASSSKSAAS KGSKDKEDNE EEDGDHDMTD FKDAMSEQ
//
