ID Q6C6B8_YARLI Unreviewed; 893 AA.
AC Q6C6B8;
DT 16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT 16-AUG-2004, sequence version 1.
DT 24-JAN-2024, entry version 127.
DE SubName: Full=YALI0E10769p {ECO:0000313|EMBL:CAG79385.1};
GN ORFNames=YALI0_E10769g {ECO:0000313|EMBL:CAG79385.1};
OS Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Dipodascaceae; Yarrowia.
OX NCBI_TaxID=284591 {ECO:0000313|EMBL:CAG79385.1, ECO:0000313|Proteomes:UP000001300};
RN [1] {ECO:0000313|EMBL:CAG79385.1, ECO:0000313|Proteomes:UP000001300}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CLIB 122 / E 150 {ECO:0000313|Proteomes:UP000001300};
RX PubMed=15229592; DOI=10.1038/nature02579;
RG Genolevures;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.F., Straub M.L.,
RA Suleau A., Swennene D., Tekaia F., Wesolowski-Louvel M., Westhof E.,
RA Wirth B., Zeniou-Meyer M., Zivanovic I., Bolotin-Fukuhara M., Thierry A.,
RA Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA Wincker P., Souciet J.L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR EMBL; CR382131; CAG79385.1; -; Genomic_DNA.
DR RefSeq; XP_503794.1; XM_503794.1.
DR AlphaFoldDB; Q6C6B8; -.
DR STRING; 284591.Q6C6B8; -.
DR EnsemblFungi; CAG79385; CAG79385; YALI0_E10769g.
DR GeneID; 2912642; -.
DR KEGG; yli:YALI0E10769g; -.
DR VEuPathDB; FungiDB:YALI0_E10769g; -.
DR HOGENOM; CLU_004131_0_2_1; -.
DR InParanoid; Q6C6B8; -.
DR OMA; RCSKIRS; -.
DR OrthoDB; 4698638at2759; -.
DR Proteomes; UP000001300; Chromosome E.
DR GO; GO:0032389; C:MutLalpha complex; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0061982; P:meiosis I cell cycle process; IEA:UniProt.
DR GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd03484; MutL_Trans_hPMS_2_like; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF52; MISMATCH REPAIR ENDONUCLEASE PMS2; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Reference proteome {ECO:0000313|Proteomes:UP000001300}.
FT DOMAIN 215..351
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 702..847
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
FT REGION 459..635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 649..682
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 464..478
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 479..506
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 527..547
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 548..628
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 659..682
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 893 AA; 99968 MW; DE96DC0002B8672D CRC64;
MAIKAIDTAS IRQITSAQVV TDLNSAVKEV VENSLDANAK NVEIKIFDYG KDRVEIIDDG
DGIPKSEFDH VARKHMTSKI IEFDDLASVL SYGFRGEALA SICEMAELEI VTCGNTSEPA
TRLEFNRDGS IKSTKPVAGK RGTTVTIRRL FHSAIVRRKE FEKNAKNSHP GLIRMLETYA
IIRSDVRFSI VHVTNNKNRN VQLTTDGSGD MIKTVGRVFG NELKAHLMDV NFSFDVNYTK
RGFLSSEELP NYVVRVTGLV SKPVFGMGRN ANDKQLLFIN KRPFTMKKLQ KVFQDVYTSF
VHLQKPVLII NLDIPPSAYD VNVSPDKRTI MLHNEVDVIN CIRENLVDVF ESSGQSVPRH
TVDVKVQPMS SQSYWGVKDD VGEQEIEEVE DVEESGEVGP VELDHNVQLD EAATSDDVPN
QLEVRQAAAG QIERAGLFVT DQEQEEDVSM TYVEETESLV INDMTTDEAD HPREQEDEGM
VDDEAEEVEE EEEEEEEEEG QAEEEDPEKI PPEYAYIDTA ATLEDEGEDR GNDDETNDDD
DDDNDNDPTS SLSYSQSDTS MNSVSDTSIS LTTPITSRRR VTKSNVNKLN LSQFSASSRP
SSSSSTRPST ASSLPSLPAS QRASSRKRTY ANLPEFDTFG HRESLTITAE DLERGERASE
TLSTFNTSSS TSQPQTSALD DSSAESKLNL TISRNDFLNF NIIGQFNEAF IIVSDPENLF
IIDQHASDEK YNFERLQRDT KITPQPFVNP LTVELTPLEE SVVSSNLELL KKNGFLVTID
NSLPPGEKCQ IRGFPQTGNI VFGMPDFREL VVLFEDNPGN DSVRPKKVRD VFASRACRGS
VMVGTALKEK EMDRIVRNLA GLDKPWNCPH GRPTMRHLME IDKWPVFTQD YEF
//
